The average train between Amsterdam and Mainz takes 4h 27m and the fastest train takes 4h 4m. The train service runs several times per day from Amsterdam to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Amsterdam and Mainz. The earliest departure is at 6:38 AM in the morning, and the last departure from Amsterdam is at 9:01 PM which arrives into Mainz at 3:52 AM. All services require a transfer at Frankfurt(M) Flughafen Fernbf and take an average of 4h 27m. The schedules shown below are for the next available departures.

4h 6m • 1 change

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Want to know about travelling from Amsterdam to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Amsterdam to Mainz. However, there are services departing from Amsterdam station and arriving at Mainz station via Frankfurt(M) Flughafen Fernbf. The journey, including transfers, takes approximately 4h 27m.
Amsterdam to Mainz train services, operated by Nederlandse Spoorwegen (NS), depart from Amsterdam Centraal station.
Amsterdam to Mainz train services, operated by Nederlandse Spoorwegen (NS), arrive at Frankfurt(M) Flughafen Fernbf station.
Book your Amsterdam to Mainz train tickets online with Nederlandse Spoorwegen (NS), Deutsche Bahn Regio (DB Regional) and vlexx.
The distance between Amsterdam and Mainz is 355.5 km. The road distance is 452 km.
Nederlandse Spoorwegen (NS) operates a train from Amsterdam Centraal to Frankfurt(M) Flughafen Fernbf hourly. Tickets cost €45–110 and the journey takes 3h 35m.