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How to get fromAmsterdam to Mainzby train, bus, car, or plane

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There are 9 ways to get from Amsterdam to Mainz by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train via Frankfurt(M) Flughafen Fernbf

    best
    1. Take the train from Amsterdam Centraal to Frankfurt(M) Flughafen Fernbftrain train Ice / ...
    4h 13m
    €52–119

  2. Train #2

    cheapest
    1. Take the train from Amsterdam Centraal to Mainz Hbftrain train Nightjet
    5h 25m
    €45–100

  3. Bus

    1. Take the bus from Amsterdam Centraal Station to Essen Hbfbus bus Ivano-Frankivsk
    2. Take the bus from Essen central train station to Wiesbaden central train stationbus bus FlixBus 027
    8h 20m
    €49–68

  4. Drive  422.3 km

    1. Drive from Amsterdam to Mainzcar car 422.3 km
    4h 10m
    €78–112

  5. Fly Amsterdam Airport Schiphol to Frankfurt

    1. Fly from Amsterdam Airport Schiphol (AMS) to Frankfurt (FRA)plane plane AMS - FRA
    3h 55m
    €117–319

  6. Train

    1. Take the train from Amsterdam Centraal to Frankfurttrain train 78
    4h 56m
    €85–180

  7. Train via Cologne

    1. Take the train from Amsterdam Centraal to Koeln Hbftrain train Ice
    2. Take the train from Köln Hbf to Mainz, Hauptbahnhoftrain train 55 / ...
    5h
    €58–126

  8. Train to Düsseldorf International Airport, fly to Frankfurt

    1. Take the train from Amsterdam Centraal to Duesseldorf Hbftrain train
    2. Fly from Düsseldorf International Airport (DUS) to Frankfurt (FRA)plane plane DUS - FRA
    5h 2m
    €125–233

  9. Fly Amsterdam Airport Schiphol to Düsseldorf International Airport, train

    1. Fly from Amsterdam Airport Schiphol (AMS) to Düsseldorf International Airport (DUS)plane plane AMS - DUS
    2. Take the train from Duesseldorf Hbf to Frankfurt(M) Flughafen Fernbftrain train
    4h 37m
    €160–423

Amsterdam to Mainz by train

Calendar133Weekly Trains
Duration4h 13mAverage Duration
Ticket€52Cheapest Price
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Comparing Your Travel Options

Map of how to get from Amsterdam to Mainz.ExpandLaunch map view
  • Distance: 452.2 km
  • Duration: 4h 13m

What companies run services between Amsterdam, Netherlands and Mainz, Germany?

Nederlandse Spoorwegen (NS) operates a train from Amsterdam Centraal to Frankfurt(M) Flughafen Fernbf hourly. Tickets cost €45–95 and the journey takes 3h 39m. Alternatively, you can take a bus from Amsterdam Centraal Station to Wiesbaden-Mainz-Kastel Bahnhof via Essen Hbf, Essen central train station, Wiesbaden central train station, and Wiesbaden Hauptbahnhof in around 8h 20m.

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