The average train between Brussels and Mainz takes 3h 29m and the fastest train takes 3h 10m. The train service runs several times per day from Brussels to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Brussels and Mainz. The earliest departure is at 6:31 AM in the morning, and the last departure from Brussels is at 8:34 PM which arrives into Mainz at 1:22 AM. All services require a transfer at Frankfurt(M) Flughafen Fernbf and take an average of 3h 29m. The schedules shown below are for the next available departures.

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Want to know about travelling from Brussels to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brussels to Mainz. However, there are services departing from Brussels station and arriving at Mainz station via Frankfurt(M) Flughafen Fernbf. The journey, including transfers, takes approximately 3h 29m.
Brussels to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), depart from Brussels-Nord station.
Brussels to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Frankfurt(M) Flughafen Fernbf station.
Book your Brussels to Mainz train tickets online with Deutsche Bahn Intercity (DB IC), Süwex and Deutsche Bahn Regio (DB Regional).
The distance between Brussels and Mainz is 294.6 km. The road distance is 411 km.
Deutsche Bahn Intercity (DB IC) operates a train from Brussels-Nord to Frankfurt(M) Flughafen Fernbf hourly. Tickets cost €70–170 and the journey takes 2h 42m.