The average bus between Amsterdam and Mainz takes 9h 42m and the fastest bus takes 7h 30m. The bus service runs several times per day from Amsterdam to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Amsterdam and Mainz. The earliest departure is at 9:50 AM in the morning, and the last departure from Amsterdam is at 10:45 PM which arrives into Mainz at 8:15 AM. All services require a transfer, and take on average 9h 42m. The schedules shown below are for the next available departures.

7h 40m • 1 change

9h 25m • 1 change
Arrives next day

9h 30m • 1 change

7h 40m • 1 change

11h 50m • 1 change
Arrives next day

9h 30m • 1 change

7h 40m • 1 change

9h 25m • 1 change
Arrives next day

9h 30m • 1 change

7h 40m • 1 change

11h 50m • 1 change
Arrives next day

9h 30m • 1 change

7h 40m • 1 change

9h 25m • 1 change
Arrives next day

9h 30m • 1 change
Want to know about travelling from Amsterdam to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Amsterdam to Mainz. However, there are services departing from Amsterdam station and arriving at Mainz station via Frankfurt central train station station. The journey, including transfers, takes approximately 9h 42m.
Amsterdam to Mainz bus services, operated by FlixBus, depart from Amsterdam Sloterdijk station.
Amsterdam to Mainz bus services, operated by FlixBus, arrive at Frankfurt central train station.
Book your Amsterdam to Mainz bus tickets online with FlixBus.
The distance between Amsterdam and Mainz is 355.5 km. The road distance is 487 km.
FlixBus operates a bus from Amsterdam Sloterdijk to Frankfurt central train station every 2 hours. Tickets cost €30–55 and the journey takes 6h 5m.