Rome2Rio

Wesley Chapel to Key West buses

Find Transport to Key West

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The average bus between Wesley Chapel and Key West takes 32h 13m and the fastest bus takes 24h 37m. The bus runs, on average, 5 times per week from Wesley Chapel to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

32h 13m
Duration
479 mi
Distance
$92
Average price
5 times a week
Frequency

Wesley Chapel to Key West bus times

Buses run 5 times a week between Wesley Chapel and Key West. The earliest departure is at 12:24 PM in the afternoon, and the last departure from Wesley Chapel is at 5:24 PM which arrives into Key West at 1:02 PM. All services require a transfer at Wiregrass Park n Ride and take an average of 32h 13m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Pasco County Public TransportationHillsborough Area Regional TransitUSF Bull RunnerFlixbus USAGreyhound USAKey West Transit24h 37m • 5 changes
  •  → 

    Arrives +2 days

    Pasco County Public TransportationHillsborough Area Regional TransitUSF Bull RunnerFlixbus USAGreyhound USAKey West Transit43h 37m • 5 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Pasco County Public TransportationHillsborough Area Regional TransitUSF Bull RunnerFlixbus USAGreyhound USAKey West Transit43h 37m • 5 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Pasco County Public TransportationHillsborough Area Regional TransitUSF Bull RunnerFlixbus USAGreyhound USAKey West Transit24h 37m • 5 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Pasco County Public TransportationHillsborough Area Regional TransitUSF Bull RunnerFlixbus USAGreyhound USAKey West Transit24h 37m • 5 changes

Frequently asked questions

Want to know about travelling from Wesley Chapel to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Wesley Chapel to Key West.ExpandLaunch map view
  • Distance: 478.7 mi
  • Duration: 32h 13m

What companies run services between Wesley Chapel, FL, USA and Key West, FL, USA?

You can take a bus from SR 54 & Saddlebrook Way to N Roosevelt & 3rd Street via Wiregrass Park n Ride, UATC to MSC, University of South Florida, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 16h 28m.

Operators