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Louisville to Key West buses

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Trip Overview

The bus between Louisville and Key West takes 42h 32m. The bus runs, on average, 6 times per week from Louisville to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h 32m
Duration
1,267 mi
Distance
$273
Average price
6 times a week
Frequency

Louisville to Key West bus times

Buses run 6 times a week between Louisville and Key West. The service departs Louisville at 6:30 PM in the evening, which arrives into Key West at 13:02:00. All services require a transfer at Nashville Bus Station and take an average of 42h 32m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

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    Arrives +2 days

    Amtrak ThruwayFlixbus USAGreyhound USAGreyhound USAKey West Transit42h 32m • 4 changes

Departing Tuesday, November 10, 2026

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    Arrives +2 days

    Amtrak ThruwayFlixbus USAGreyhound USAGreyhound USAKey West Transit42h 32m • 4 changes

Departing Wednesday, November 11, 2026

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    Arrives +2 days

    Amtrak ThruwayFlixbus USAGreyhound USAGreyhound USAKey West Transit42h 32m • 4 changes

Departing Thursday, November 12, 2026

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    Arrives +2 days

    Amtrak ThruwayFlixbus USAGreyhound USAGreyhound USAKey West Transit42h 32m • 4 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayFlixbus USAGreyhound USAGreyhound USAKey West Transit42h 32m • 4 changes

Frequently asked questions

Want to know about travelling from Louisville to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Louisville to Key West.ExpandLaunch map view
  • Distance: 1,266.8 mi
  • Duration: 42h 32m

What companies run services between Louisville, KY, USA and Key West, FL, USA?

You can take a bus from Louisville, KY to N Roosevelt & 3rd Street via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 29h 51m.

Operators