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Roanoke to Key West buses

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Trip Overview

The bus between Roanoke and Key West takes 2d 8h. The bus runs, on average, 4 times per week from Roanoke to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 8h
Duration
1,497 mi
Distance
$291
Average price
4 times a week
Frequency

Roanoke to Key West bus times

Buses run 4 times a week between Roanoke and Key West. The service departs Roanoke at 4:25 AM at night, which arrives into Key West at 13:02:00. All services require a transfer at Washington Union Station and take an average of 2d 8h. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit2d 8h • 3 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit2d 8h • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit2d 8h • 3 changes

Frequently asked questions

Want to know about travelling from Roanoke to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Roanoke to Key West.ExpandLaunch map view
  • Distance: 1,497 mi
  • Duration: 2d 8h

What companies run services between Roanoke, VA, USA and Key West, FL, USA?

You can take a bus from Roanoke Bus Stop to N Roosevelt & 3rd Street via Washington Union Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 35h 11m.

Operators