Rome2Rio

Rome Termini to Isernia buses

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Trip Overview

The average bus between Rome Termini and Isernia takes 5h 8m and the fastest bus takes 2h 25m. The bus service runs several times per day from Rome Termini to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 8m
Duration
178 km
Distance
€16
Average price
Twice daily
Frequency

Rome Termini to Isernia bus times

Buses run twice daily between Rome Termini and Isernia. The earliest departure is at 6:45 AM in the morning, and the last departure from Rome Termini is at 4:20 PM which arrives into Isernia at 7:20 PM. All services require a transfer, and take on average 5h 8m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 35m • 1 change
  •  → 

    ATAC S.p.A. Azienda per la mobilitàATM Azienda di Trasporti Molisana S.p.A.3h • 1 change

Departing Monday, November 16, 2026

  •  → 

    Cotral S.p.A.ATM Azienda di Trasporti Molisana S.p.A.6h 39m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Cotral S.p.A.ATM Azienda di Trasporti Molisana S.p.A.6h 39m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    Cotral S.p.A.ATM Azienda di Trasporti Molisana S.p.A.6h 39m • 1 change

Departing Thursday, November 19, 2026

  •  → 

    Cotral S.p.A.ATM Azienda di Trasporti Molisana S.p.A.6h 39m • 1 change

Departing Friday, November 20, 2026

  •  → 

    Cotral S.p.A.ATM Azienda di Trasporti Molisana S.p.A.6h 39m • 1 change

Departing Saturday, November 21, 2026

  •  → 

    ATAC S.p.A. Azienda per la mobilitàATM Azienda di Trasporti Molisana S.p.A.2h 25m • 1 change
  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 35m • 1 change
  •  → 

    ATAC S.p.A. Azienda per la mobilitàATM Azienda di Trasporti Molisana S.p.A.3h 40m • 1 change
  •  → 

    ATAC S.p.A. Azienda per la mobilitàATM Azienda di Trasporti Molisana S.p.A.4h 20m • 1 change

Frequently asked questions

Want to know about travelling from Rome Termini to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Rome Termini to Isernia.ExpandLaunch map view
  • Distance: 178.2 km
  • Duration: 5h 8m

What companies run services between Rome Termini, Italy and Isernia, Italy?

ATM Azienda di Trasporti Molisana S.p.A. operates a bus from Roma, Autostazione Tiburtina to Isernia 3 times a day. Tickets cost €8–13 and the journey takes 2h 10m. FlixBus also services this route once daily.

Operators