The average bus between Rome Termini and Isernia takes 2h 42m and the fastest bus takes 2h 32m. The bus service runs several times per day from Rome Termini to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Rome Termini and Isernia. The earliest departure is at 10:51 AM in the morning, and the last departure from Rome Termini is at 8:35 PM which arrives into Isernia at 11:10 PM. All services require a transfer at Indipendenza and take an average of 2h 42m. The schedules shown below are for the next available departures.

2h 33m • 1 change

3h 2m • 1 change

2h 43m • 1 change

2h 32m • 1 change

2h 33m • 1 change

3h 2m • 1 change

2h 43m • 1 change

2h 32m • 1 change

2h 33m • 1 change

3h 2m • 1 change

2h 43m • 1 change

2h 32m • 1 change

2h 33m • 1 change

3h 2m • 1 change

2h 43m • 1 change

2h 32m • 1 change

2h 33m • 1 change

3h 2m • 1 change

2h 43m • 1 change

2h 32m • 1 change
Want to know about travelling from Rome Termini to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome Termini to Isernia. However, there are services departing from Rome Termini station and arriving at Isernia station via Isernia. The journey, including transfers, takes approximately 2h 42m.
Rome Termini to Isernia bus services, operated by ATAC S.p.A. Azienda per la mobilità, depart from Roma, Autostazione Tiburtina station.
Rome Termini to Isernia bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Isernia station.
The distance between Rome Termini and Isernia is 147.7 km. The road distance is 178 km.
ATM Azienda di Trasporti Molisana S.p.A. operates a bus from Roma, Autostazione Tiburtina to Isernia 3 times a day. Tickets cost €8–13 and the journey takes 2h 10m. FlixBus also services this route once daily.