The average bus between Roma Termini and Isernia takes 3h 47m and the fastest bus takes 2h 25m. The bus service runs several times per day from Roma Termini to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Roma Termini and Isernia. The earliest departure is at 5:35 AM in the morning, and the last departure from Roma Termini is at 8:33 PM which arrives into Isernia at 11:10 PM. All services require a transfer, and take on average 3h 47m. The schedules shown below are for the next available departures.

2h 44m • 1 change

2h 40m • 1 change

2h 39m • 1 change

2h 50m • 1 change

2h 25m • 1 change

2h 44m • 1 change

2h 45m • 1 change

2h 48m • 1 change
Want to know about travelling from Roma Termini to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Roma Termini to Isernia. However, there are services departing from Roma Termini station and arriving at Isernia station via Isernia. The journey, including transfers, takes approximately 3h 47m.
Roma Termini to Isernia bus services, operated by ATAC S.p.A. Azienda per la mobilità, depart from Roma, Autostazione Tiburtina station.
Roma Termini to Isernia bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Isernia station.
The distance between Roma Termini and Isernia is 147.6 km. The road distance is 179 km.
ATM Azienda di Trasporti Molisana S.p.A. operates a bus from Roma, Autostazione Tiburtina to Isernia 3 times a day. Tickets cost €8–13 and the journey takes 2h 10m. FlixBus also services this route once daily.