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Jacksonville to Key West buses

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Trip Overview

The average bus between Jacksonville and Key West takes 24h 29m and the fastest bus takes 21h 12m. There is at least one bus per day from Jacksonville to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

24h 29m
Duration
573 mi
Distance
$120
Average price
Once daily
Frequency

Jacksonville to Key West bus times

Buses run once daily between Jacksonville and Key West. The earliest departure is at 10:30 AM in the morning, and the last departure from Jacksonville is at 3:50 PM which arrives into Key West at 1:02 PM. All services require a transfer at Miami Airport Station and take an average of 24h 29m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit26h 32m • 2 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit21h 12m • 2 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit21h 12m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit26h 32m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit26h 32m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USAKey West Transit21h 12m • 2 changes

Frequently asked questions

Want to know about travelling from Jacksonville to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Jacksonville to Key West.ExpandLaunch map view
  • Distance: 573 mi
  • Duration: 24h 29m

What companies run services between Jacksonville, FL, USA and Key West, FL, USA?

You can take a bus from Jacksonville to N Roosevelt & 3rd Street via Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 16h 11m.

Operators