The average bus between Pisa and Lyon takes 12h 11m and the fastest bus takes 10h 45m. The bus service runs several times per day from Pisa to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Pisa and Lyon. The earliest departure is at 6:25 AM in the morning, and the last departure from Pisa is at 11:30 PM which arrives into Lyon at 12:00 PM. All services require a transfer at Genoa and take an average of 12h 11m. The schedules shown below are for the next available departures.
Arrives next day


14h 35m • 2 changes
Arrives next day


12h 30m • 2 changes


11h 45m • 2 changes
Arrives next day


10h 45m • 2 changes
Arrives next day


11h 10m • 2 changes
Arrives next day


14h 35m • 2 changes


11h 45m • 2 changes
Arrives next day


10h 45m • 2 changes
Arrives next day


11h 10m • 2 changes
Arrives next day


14h 35m • 2 changes
Want to know about travelling from Pisa to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Lyon. However, there are services departing from Pisa station and arriving at Lyon station via Genoa. The journey, including transfers, takes approximately 12h 11m.
Pisa to Lyon bus services, operated by FlixBus, depart from Pisa station.
Pisa to Lyon bus services, operated by FlixBus, arrive at Lyon - Gerland Bus Station.
Book your Pisa to Lyon bus tickets online with FlixBus.
The distance between Pisa and Lyon is 494 km. The road distance is 653 km.
You can take a bus from Pisa to Lyon - Gerland Bus Station via Genoa and Turin - Vittorio Emanuele Bus Station in around 10h 57m.