The average bus between Pisa and Lyon takes 13h 11m and the fastest bus takes 12h 55m. The bus service runs several times per day from Pisa to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Pisa and Lyon. The earliest departure is at 4:45 AM at night, and the last departure from Pisa is at 5:10 PM which arrives into Lyon at 6:05 AM. All services require a transfer, and take on average 13h 11m. The schedules shown below are for the next available departures.
Arrives next day

13h 20m • 1 change
Arrives next day

12h 55m • 1 change

13h 25m • 1 change
Arrives next day

13h 20m • 1 change
Arrives next day

12h 55m • 1 change

13h 25m • 1 change
Arrives next day

13h 20m • 1 change
Arrives next day

12h 55m • 1 change
Want to know about travelling from Pisa to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Lyon. However, there are services departing from Pisa station and arriving at Lyon station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 13h 11m.
Pisa to Lyon bus services, operated by FlixBus, depart from Pisa station.
Pisa to Lyon bus services, operated by FlixBus, arrive at Lyon station.
Book your Pisa to Lyon bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Pisa and Lyon is 494 km. The road distance is 815 km.
You can take a bus from Pisa to Lyon via Florence Villa Constanza Bus Station in around 12h 40m.