The average bus between Lyon and Avignon takes 3h 39m and the fastest bus takes 2h 55m. The bus service runs several times per day from Lyon to Avignon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Lyon and Avignon. The earliest departure is at 3:35 AM at night, and the last departure from Lyon is at 11:50 PM which arrives into Avignon at 6:00 AM. All services require a transfer, and take on average 3h 39m. The schedules shown below are for the next available departures.

3h 2m • 1 change
3h 18m • 1 change
2h 58m • 1 change
3h • 1 change
3h 2m • 1 change
3h 18m • 1 change
2h 58m • 1 change
3h 48m • 1 change
3h 18m • 1 change
2h 58m • 1 change
3h • 1 change
3h 40m • 1 change
3h 18m • 1 change
2h 58m • 1 change
3h • 1 change
3h 40m • 1 change
2h 55m • 1 change
3h 20m • 1 change
2h 55m • 1 change
3h 3m • 1 changeWant to know about travelling from Lyon to Avignon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Avignon. However, there are services departing from Lyon station and arriving at Avignon station via Avignon station. The journey, including transfers, takes approximately 3h 39m.
Lyon to Avignon bus services, operated by FlixBus, depart from Lyon station.
Lyon to Avignon bus services, operated by FlixBus, arrive at Avignon station.
Book your Lyon to Avignon bus tickets online with Omio.
The distance between Lyon and Avignon is 200.2 km. The road distance is 226 km.
FlixBus operates a bus from Lyon to Avignon 5 times a day. Tickets cost €20–30 and the journey takes 2h 40m. BlaBlaCar Bus also services this route 5 times a day.