The average bus between Lyon and Avignon takes 3h 41m and the fastest bus takes 2h 56m. The bus service runs several times per day from Lyon to Avignon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Lyon and Avignon. The earliest departure is at 1:35 AM at night, and the last departure from Lyon is at 11:50 PM which arrives into Avignon at 6:00 AM. All services require a transfer, and take on average 3h 41m. The schedules shown below are for the next available departures.

3h 48m • 1 change

3h 47m • 1 change
Arrives next day

6h 10m • 1 change

3h 19m • 1 change

3h 8m • 1 change

3h 23m • 1 change

3h 48m • 1 change

3h 19m • 1 change

3h 8m • 1 change

3h 23m • 1 change

3h 48m • 1 change

4h 25m • 1 change

3h 19m • 1 change

3h 8m • 1 change

3h 40m • 1 change

4h 24m • 1 change

3h 20m • 1 change

2h 56m • 1 change

3h 5m • 1 change

5h 36m • 1 change

2h 57m • 1 change

3h 14m • 1 change

3h 49m • 1 change
Want to know about travelling from Lyon to Avignon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Avignon. However, there are services departing from Lyon station and arriving at Avignon station via Avignon. The journey, including transfers, takes approximately 3h 41m.
Lyon to Avignon bus services, operated by BlaBlaCar Bus, depart from Lyon station.
Lyon to Avignon bus services, operated by BlaBlaCar Bus, arrive at Avignon station.
Book your Lyon to Avignon bus tickets online with BlaBlaCar Bus, TECELYS SPL and FlixBus.
The distance between Lyon and Avignon is 200.2 km. The road distance is 230 km.
FlixBus operates a bus from Lyon to Avignon every 4 hours. Tickets cost €15–27 and the journey takes 3h. BlaBlaCar Bus also services this route 5 times a day.