The average bus between Philadelphia and Depew takes 15h 42m and the fastest bus takes 11h 26m. The bus service runs several times per day from Philadelphia to Depew. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Philadelphia and Depew. The earliest departure is at 5:20 AM in the morning, and the last departure from Philadelphia is at 10:30 PM which arrives into Depew at 10:57 AM. All services require a transfer at Newark Penn Station and take an average of 15h 42m. The schedules shown below are for the next available departures.
Arrives next day


21h 18m • 2 changes
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13h 56m • 2 changes
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12h 27m • 2 changes


13h 4m • 2 changes
Arrives next day


21h 18m • 2 changes
Arrives next day


12h 27m • 2 changes


13h 4m • 2 changes
Arrives next day


21h 18m • 2 changes
Arrives next day


15h 11m • 2 changes
Arrives next day


12h 27m • 2 changes
Want to know about travelling from Philadelphia to Depew? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Philadelphia to Depew. However, there are services departing from Philadelphia station and arriving at Depew station via Newark Penn Station station. The journey, including transfers, takes approximately 15h 42m.
Philadelphia to Depew bus services, operated by Greyhound USA, depart from Philadelphia Bus Station.
Philadelphia to Depew bus services, operated by Greyhound USA, arrive at Buffalo station.
The distance between Philadelphia and Depew is 440.7 km. The road distance is 804 km.
You can take a bus from Philadelphia Bus Station to Broadway & Elwood Avenue via Newark Penn Station and Ellicott Street & MTC Static in around 12h 29m.