The average bus between Manhattan and Depew takes 11h 13m and the fastest bus takes 9h 56m. The bus service runs several times per day from Manhattan to Depew. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Manhattan and Depew. The earliest departure is at 8:00 AM in the morning, and the last departure from Manhattan is at 11:59 PM which arrives into Depew at 10:57 AM. All services require a transfer, and take on average 11h 13m. The schedules shown below are for the next available departures.

10h 24m • 1 change

10h 24m • 1 change
Arrives next day

13h 38m • 1 change
Arrives next day

9h 58m • 1 change

10h 24m • 1 change

10h 24m • 1 change
Arrives next day

13h 38m • 1 change
Arrives next day

10h 56m • 1 change

10h 24m • 1 change

10h 24m • 1 change
Arrives next day

13h 38m • 1 change
Arrives next day

9h 56m • 1 change
Want to know about travelling from Manhattan to Depew? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manhattan to Depew. However, there are services departing from Manhattan station and arriving at Depew station via Buffalo. The journey, including transfers, takes approximately 11h 13m.
Manhattan to Depew bus services, operated by Flixbus USA, depart from New York Midtown station.
Manhattan to Depew bus services, operated by Flixbus USA, arrive at Buffalo station.
The distance between Manhattan and Depew is 456.9 km. The road distance is 705 km.
Flixbus USA operates a bus from New York Midtown to Buffalo every 2 hours. Tickets cost $55–95 and the journey takes 7h 55m.