The average bus between Pennsylvania and Chicago takes 22h 44m and the fastest bus takes 19h 9m. The bus service runs several times per day from Pennsylvania to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Pennsylvania and Chicago. The earliest departure is at 12:01 PM in the afternoon, and the last departure from Pennsylvania is at 5:35 PM which arrives into Chicago at 6:55 PM. All services require a transfer, and take on average 22h 44m. The schedules shown below are for the next available departures.
Arrives next day

18h 9m • 1 change
Arrives next day

25h 20m • 1 change
Arrives next day

18h 9m • 1 change
Arrives next day

25h 20m • 1 change
Arrives next day

18h 9m • 1 change
Arrives next day

25h 20m • 1 change
Arrives next day

18h 9m • 1 change
Arrives next day

25h 20m • 1 change
Want to know about travelling from Pennsylvania to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pennsylvania to Chicago. However, there are services departing from Pennsylvania station and arriving at Chicago station via Harrisburg Bus Station station. The journey, including transfers, takes approximately 22h 44m.
Pennsylvania to Chicago bus services, operated by Greyhound USA, depart from Philadelphia Bus Station.
Pennsylvania to Chicago bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Book your Pennsylvania to Chicago bus tickets online with Greyhound USA and Flixbus USA.
The distance between Pennsylvania and Chicago is 831.1 km. The road distance is 1,420 km.
You can take a bus from Philadelphia Bus Station to Chicago Bus Station via Harrisburg Bus Station in around 19h 30m.