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Myrtle Beach to Key West buses

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Trip Overview

The bus between Myrtle Beach and Key West takes 47h 52m. The bus runs, on average, 3 times per week from Myrtle Beach to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

47h 52m
Duration
1,088 mi
Distance
$214
Average price
3 times a week
Frequency

Myrtle Beach to Key West bus times

Buses run 3 times a week between Myrtle Beach and Key West. The service departs Myrtle Beach at 1:10 PM in the afternoon, which arrives into Key West at 13:02:00. All services require a transfer at Fayetteville Bus Station and take an average of 47h 52m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit47h 52m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit47h 52m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit47h 52m • 3 changes

Frequently asked questions

Want to know about travelling from Myrtle Beach to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Myrtle Beach to Key West.ExpandLaunch map view
  • Distance: 1,088.3 mi
  • Duration: 47h 52m

What companies run services between Myrtle Beach, SC, USA and Key West, FL, USA?

You can take a bus from Myrtle Beach Bus Station to N Roosevelt & 3rd Street via Fayetteville Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 26h 31m.

Operators