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Myrtle Beach to Roanoke buses

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Trip Overview

The bus between Myrtle Beach and Roanoke takes 42h 54m. The bus runs, on average, 2 times per week from Myrtle Beach to Roanoke. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h 54m
Duration
496 mi
Distance
$101
Average price
Twice a week
Frequency

Myrtle Beach to Roanoke bus times

Buses run twice a week between Myrtle Beach and Roanoke. The service departs Myrtle Beach at 5:05 PM in the evening, which arrives into Roanoke at 11:59:00. All services require a transfer at Raleigh Bus Station and take an average of 42h 54m. The schedules shown below are for the next available departures.

Departing Sunday, October 25, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAGreyhound USA42h 54m • 3 changes

Departing Thursday, October 29, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAGreyhound USA42h 54m • 3 changes

Frequently asked questions

Want to know about travelling from Myrtle Beach to Roanoke? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Myrtle Beach to Roanoke.ExpandLaunch map view
  • Distance: 495.8 mi
  • Duration: 42h 54m

What companies run services between Myrtle Beach, SC, USA and Roanoke, VA, USA?

You can take a bus from Myrtle Beach Bus Station to Roanoke Bus Stop via Raleigh Bus Station, Greensboro Bus Stop, and Lynchburg Transit Center in around 13h 39m.

Operators