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Manhattan to St. Louis buses

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Trip Overview

The average bus between Manhattan and St. Louis takes 23h 43m and the fastest bus takes 23h. The bus service runs several times per day from Manhattan to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

23h 43m
Duration
1,049 mi
Distance
$220
Average price
3 times a day
Frequency

Manhattan to St. Louis bus times

Buses run 3 times a day between Manhattan and St. Louis. The earliest departure is at 1:05 AM at night, and the last departure from Manhattan is at 3:10 PM which arrives into St. Louis at 3:10 PM. All services run direct with no transfers required, and take on average 23h 43m. The schedules shown below are for the next available departures.

Departing Friday, October 23, 2026

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    bus bus 23h 10m • Direct
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    Arrives next day

    bus bus 23h • Direct
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    Arrives next day

    bus bus 25h • Direct

Departing Saturday, October 24, 2026

  •  → 

    bus bus 23h 10m • Direct
  •  → 

    Arrives next day

    bus bus 23h • Direct
  •  → 

    Arrives next day

    bus bus 25h • Direct

Departing Sunday, October 25, 2026

  •  → 

    bus bus 23h 10m • Direct
  •  → 

    Arrives next day

    bus bus 23h • Direct
  •  → 

    Arrives next day

    bus bus 25h • Direct

Departing Monday, October 26, 2026

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    bus bus 23h 10m • Direct
  •  → 

    Arrives next day

    bus bus 23h • Direct
  •  → 

    Arrives next day

    bus bus 25h • Direct

Departing Tuesday, October 27, 2026

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    bus bus 23h 10m • Direct
  •  → 

    Arrives next day

    bus bus 23h • Direct
  •  → 

    Arrives next day

    bus bus 25h • Direct

Departing Wednesday, October 28, 2026

  •  → 

    bus bus 23h 10m • Direct
  •  → 

    Arrives next day

    bus bus 23h • Direct
  •  → 

    Arrives next day

    bus bus 25h • Direct

Departing Thursday, October 29, 2026

  •  → 

    bus bus 23h 10m • Direct
  •  → 

    Arrives next day

    bus bus 23h • Direct
  •  → 

    Arrives next day

    bus bus 25h • Direct

Frequently asked questions

Want to know about travelling from Manhattan to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Manhattan to St. Louis.ExpandLaunch map view
  • Distance: 1,048.8 mi
  • Duration: 23h 43m

What companies run services between Manhattan, NY, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Port Authority Bus Terminal to St Louis Bus Station 3 times a day. Tickets cost $180–280 and the journey takes 23h.

Operators