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How to get fromManhattan to St. Louisby plane, bus (Greyhound), train (Amtrak), car or train

Find Transport to St. Louis

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There are 8 ways to get from Manhattan to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Laguardia Airport

    best
    1. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)planeLGA - STL
    4h 59m
    $206–460

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Port Authority Bus Terminal to St Louis Bus StationbusGreyhound US0421
    22h 50m
    $85–270

  3. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union StationtrainLake Shore Limited / ...
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    26h 48m
    $163–727

  4. Drive 947 mi

    1. Drive from Manhattan to St. Louiscar947 mi
    16h 21m
    $173–250

  5. Fly from Newark Liberty International Airport

    1. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)planeEWR - STL
    5h 3m
    $173–480

  6. Fly from John F. Kennedy International Airport

    1. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)planeJFK - STL
    5h 15m
    $137–671

  7. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)planePHL - STL
    6h 25m
    $206–1,089

  8. Train to Long Island Mac Arthur Airport, fly

    1. Take the train from New York Penn Station to Central Isliptrain
    2. Fly from Long Island Mac Arthur Airport (ISP) to Lambert–St. Louis International Airport (STL)planeISP - STL
    8h 7m
    $158–783

Manhattan to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration22h 50mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

What companies run services between Manhattan, NY, USA and St. Louis, MO, USA?

American Airlines, Delta, and Southwest Airlines fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Port Authority Bus Terminal to St Louis Bus Station 3 times a day. Tickets cost $85–270 and the journey takes 22h 50m.

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