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There are 6 ways to get from Manhattan to St. Louis by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from New York La Guardia  •  4h 56m

  1. Fly from New York La Guardia (LGA) to St. Louis (STL) LGA - STL

$148 - $363

Cheapest option

Bus  •  25h 5m

  1. Take the bus from New York, Ny to St Louis, Mo 1683 / ...

$95 - $250

4 alternative options

Fly from Newark  •  4h 56m

  1. Fly from Newark (EWR) to St. Louis (STL) EWR - STL

$160 - $450

Train to Philadelphia, fly  •  6h 30m

  1. Take the train from New York Penn Station to Philadelphia 30th Street Station
  2. Fly from Philadelphia (PHL) to St. Louis (STL) PHL - STL

$248 - $613

Train  •  26h 48m

  1. Take the train from New York Penn Station to Chicago Union Station Lake Shore Limited
  2. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$173 - $503

Drive  •  16h 12m

  1. Drive from Manhattan to St. Louis 961.5 miles

$90 - $140

Questions & Answers

The cheapest way to get from Manhattan to St. Louis is to drive which costs $90 - $140 and takes 16h 12m.

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The quickest way to get from Manhattan to St. Louis is to fly which costs $160 - $450 and takes 4h 56m.

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Yes, there is a direct bus departing from New York, Ny and arriving at St Louis, Mo. Services depart five times a day, and operate every day. The journey takes approximately 25h 5m.

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The distance between Manhattan and St. Louis is 879 miles. The road distance is 961.5 miles.

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The best way to get from Manhattan to St. Louis without a car is to bus which takes 25h 5m and costs $95 - $250.

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It takes approximately 4h 56m to get from Manhattan to St. Louis, including transfers.

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Manhattan to St. Louis bus services, operated by Greyhound USA, depart from New York, Ny station.

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The best way to get from Manhattan to St. Louis is to fly which takes 4h 56m and costs $140 - $370. Alternatively, you can bus, which costs $95 - $250 and takes 25h 5m, you could also train, which costs $170 - $550 and takes 26h 48m.

Mode details

The quickest flight from New York La Guardia Airport to St. Louis Airport is the direct flight which takes 2h 50m.

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Manhattan to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

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Map of how to get from Manhattan to St. Louis.
Launch map view
  • Distance: 879.4 miles
  • Duration: 4h 56m

What companies run services between Manhattan, NY, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines and three other airlines fly from Manhattan to St. Louis hourly. Alternatively, Greyhound USA operates a bus from Manhattan to St. Louis 5 times a day. Tickets cost $95 - $250 and the journey takes 25h 5m.

Airlines
Southwest Airlines
Website
southwest.com
Flights from New York La Guardia to St. Louis
Ave. Duration
2h 55m
When
Every day
Estimated price
$320 - $750
Flights from New York La Guardia to St. Louis via Chicago Midway
Ave. Duration
4h 47m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$320 - $750
Flights from Newark to St. Louis
Ave. Duration
2h 50m
When
Every day
Estimated price
$300 - $950
Flights from Newark to St. Louis via Chicago Midway
Ave. Duration
4h 42m
When
Monday to Saturday
Estimated price
$300 - $950
Flights from Philadelphia to St. Louis
Ave. Duration
2h 38m
When
Every day
Estimated price
$340 - $900
Flights from Philadelphia to St. Louis via Nashville
Ave. Duration
4h 10m
When
Monday to Friday
Estimated price
$340 - $900
Flights from Philadelphia to St. Louis via Chicago Midway
Ave. Duration
4h 32m
When
Saturday and Sunday
Estimated price
$340 - $900
American Airlines
Website
aa.com
Flights from New York La Guardia to St. Louis
Ave. Duration
3h 1m
When
Every day
Estimated price
$230 - $650
Flights from Newark to St. Louis via Chicago O'Hare
Ave. Duration
4h 49m
When
Every day
Estimated price
$240 - $900
Flights from Philadelphia to St. Louis
Ave. Duration
2h 42m
When
Every day
Estimated price
$200 - $750
Flights from Philadelphia to St. Louis via Chicago O'Hare
Ave. Duration
4h 35m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $750
Flights from Philadelphia to St. Louis via Reagan Washington
Ave. Duration
4h 39m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $750
United Airlines
Website
united.com
Flights from New York La Guardia to St. Louis via Washington Dulles
Ave. Duration
4h 50m
When
Every day
Estimated price
$290 - $700
Flights from Newark to St. Louis
Ave. Duration
2h 59m
When
Every day
Estimated price
$190 - $950
Delta
Website
delta.com
Flights from New York La Guardia to St. Louis
Ave. Duration
3h 4m
When
Every day
Estimated price
$230 - $700
Flights from Philadelphia to St. Louis via Detroit
Ave. Duration
4h 36m
When
Saturday
Estimated price
$280 - $800
Train operators
Amtrak Acela Express

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Acela Express
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from New York Penn Station to Philadelphia 30th Street Station
Ave. Duration
1h 9m
Frequency
Every 30 minutes
Estimated price
$75 - $210
Website
amtrak.com
Business Seat
$75 - $180
First Class Seat
$150 - $210
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from New York Penn Station to Chicago Union Station
Ave. Duration
19h 10m
Frequency
Once daily
Estimated price
$120 - $370
Website
amtrak.com
Coach Seat
$120 - $190
Flexi Coach Seat
$220 - $330
Business Coach Seat
$260 - $370
Room
$500 - $700
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5h 30m
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from New York, Ny to St Louis, Mo
Ave. Duration
25h 5m
Frequency
5 times a day
Estimated price
$95 - $250
Website
greyhound.com
Economy
$95 - $160
Flexible
$190 - $250

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

St. Louis is 1h behind Manhattan. It is currently 7:22 AM in Manhattan and 6:22 AM in St. Louis.

Yes, the driving distance between Manhattan to St. Louis is 961 miles. It takes approximately 16h 12m to drive from Manhattan to St. Louis.

Get driving directions

American Airlines, United Airlines, Delta and Southwest Airlines offer flights from New York La Guardia Airport to St. Louis Airport.

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Book your Manhattan to St. Louis bus tickets online with Greyhound.

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There are 202+ hotels available in St. Louis. Prices start at $64 USD per night.

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The best way to get from Manhattan to Newark Airport is to bus which takes 20m and costs $17.

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