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How to get fromManhattan to St. Louisby plane, bus (Greyhound), train (Amtrak), car or train

Find Transport to St. Louis

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There are 8 ways to get from Manhattan to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Laguardia Airport

    best
    1. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    4h 54m
    $316–810

  2. Fly from John F. Kennedy International Airport

    cheapest
    1. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)plane plane JFK - STL
    5h 8m
    $137–671

  3. Bus (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    23h
    $170–330

  4. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    26h 48m
    $338–777

  5. Drive 947 mi

    1. Drive from Manhattan to St. Louiscar car 947 mi
    16h 34m
    $173–250

  6. Fly from Newark Liberty International Airport

    1. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    5h 10m
    $303–580

  7. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    6h 21m
    $239–1,202

  8. Train to Long Island Mac Arthur Airport, fly

    1. Take the train from New York Penn Station to Central Isliptrain train
    2. Fly from Long Island Mac Arthur Airport (ISP) to Lambert–St. Louis International Airport (STL)plane plane ISP - STL
    8h 24m
    $229–1,133

Manhattan to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration23hAverage Duration
Ticket$170Cheapest Price
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Questions & Answers

What companies run services between Manhattan, NY, USA and St. Louis, MO, USA?

American Airlines, Delta, and Southwest Airlines fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, Greyhound USA operates a bus from Port Authority Bus Terminal to St Louis Bus Station 3 times a day. Tickets cost $170–330 and the journey takes 23h.

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