The average bus between Manhattan and Duke University takes 12h 7m and the fastest bus takes 10h 42m. The bus service runs several times per day from Manhattan to Duke University. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Manhattan and Duke University. The earliest departure is at 10:15 AM in the morning, and the last departure from Manhattan is at 10:00 PM which arrives into Duke University at 8:42 AM. All services require a transfer at Durham and take an average of 12h 7m. The schedules shown below are for the next available departures.

12h 27m • 1 change
Arrives next day

14h 12m • 1 change
Arrives next day

10h 42m • 1 change

12h 27m • 1 change
Arrives next day

15h 12m • 1 change
Arrives next day

10h 42m • 1 change
Arrives next day

14h 12m • 1 change
Arrives next day

10h 42m • 1 change
Want to know about travelling from Manhattan to Duke University? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manhattan to Duke University. However, there are services departing from Manhattan station and arriving at Duke University station via Durham. The journey, including transfers, takes approximately 12h 7m.
Manhattan to Duke University bus services, operated by Flixbus USA, depart from New York Midtown station.
Manhattan to Duke University bus services, operated by Flixbus USA, arrive at Durham station.
The distance between Manhattan and Duke University is 685.8 km. The road distance is 904 km.
Flixbus USA operates a bus from New York Midtown to Durham 3 times a day. Tickets cost $70–130 and the journey takes 10h 25m.