The average bus between Mainz and Perugia takes 22h 31m and the fastest bus takes 21h 45m. There is at least one bus per day from Mainz to Perugia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Mainz and Perugia. The earliest departure is at 4:00 PM in the afternoon, and the last departure from Mainz is at 8:00 PM which arrives into Perugia at 11:30 PM. All services require a transfer at Frankfurt central train station and take an average of 22h 31m. The schedules shown below are for the next available departures.
Arrives next day


21h 45m • 2 changes
Arrives next day


22h 10m • 2 changes
Arrives next day


21h 45m • 2 changes
Arrives next day


22h 10m • 2 changes
Want to know about travelling from Mainz to Perugia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mainz to Perugia. However, there are services departing from Mainz station and arriving at Perugia station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 22h 31m.
Mainz to Perugia bus services, operated by FlixBus, depart from Frankfurt central train station.
Mainz to Perugia bus services, operated by FlixBus, arrive at Perugia station.
Book your Mainz to Perugia bus tickets online with FlixBus.
The distance between Mainz and Perugia is 825.9 km. The road distance is 1,261 km.
You can take a bus from Mainz central train station to Perugia via Frankfurt central train station and Florence Villa Constanza Bus Station in around 22h 5m.