The average bus between Mainz and Florence takes 17h 48m and the fastest bus takes 16h 45m. The bus service runs several times per day from Mainz to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Mainz and Florence. The earliest departure is at 4:00 PM in the afternoon, and the last departure from Mainz is at 8:00 PM which arrives into Florence at 12:45 PM. All services require a transfer at Wiesbaden Hauptbahnhof and take an average of 17h 48m. The schedules shown below are for the next available departures.
Arrives next day

18h 25m • 1 change
Arrives next day

16h 45m • 1 change
Arrives next day

18h 25m • 1 change
Arrives next day

16h 45m • 1 change
Arrives next day

18h 25m • 1 change
Arrives next day

16h 45m • 1 change
Want to know about travelling from Mainz to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mainz to Florence. However, there are services departing from Mainz station and arriving at Florence station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 17h 48m.
Mainz to Florence bus services, operated by FlixBus, depart from Wiesbaden Gartenfeldstraße P+R station.
Mainz to Florence bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Book your Mainz to Florence bus tickets online with FlixBus.
The distance between Mainz and Florence is 725.7 km. The road distance is 1,765 km.
Onebus operates a bus from Wiesbaden Gartenfeldstraße P+R to Florence Villa Constanza Bus Station once a week, and the journey takes 15h 5m.