Rome2Rio

Louisville to Key Largo buses

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Trip Overview

The bus between Louisville and Key Largo takes 47h. The bus runs, on average, 5 times per week from Louisville to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

47h
Duration
1,166 mi
Distance
$249
Average price
5 times a week
Frequency

Louisville to Key Largo bus times

Buses run 5 times a week between Louisville and Key Largo. The service departs Louisville at 7:25 AM in the morning, which arrives into Key Largo at 06:25:00. All services require a transfer at Nashville Bus Station and take an average of 47h. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAFlixbus USAGreyhound USA47h • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAFlixbus USAGreyhound USA47h • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAFlixbus USAGreyhound USA47h • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAFlixbus USAGreyhound USA47h • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAFlixbus USAGreyhound USA47h • 3 changes

Frequently asked questions

Want to know about travelling from Louisville to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Louisville to Key Largo.ExpandLaunch map view
  • Distance: 1,166.2 mi
  • Duration: 47h

What companies run services between Louisville, KY, USA and Key Largo, FL, USA?

You can take a bus from Louisville, KY to Key Largo Bus Stop via Nashville Bus Station, Atlanta Bus Station, and Miami Airport Station in around 25h 15m.

Operators