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Key Largo to Jacksonville buses

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Trip Overview

The average bus between Key Largo and Jacksonville takes 18h 30m and the fastest bus takes 18h 20m. There is at least one bus per day from Key Largo to Jacksonville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

18h 30m
Duration
474 mi
Distance
$102
Average price
Once daily
Frequency

Key Largo to Jacksonville bus times

Buses run once daily between Key Largo and Jacksonville. The service departs Key Largo at 8:00 PM in the evening, which arrives into Jacksonville at 14:20:00. All services require a transfer, and take on average 18h 30m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAFlixbus USA18h 20m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAFlixbus USA18h 20m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAGreyhound USA18h 45m • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAFlixbus USA18h 20m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAFlixbus USA18h 20m • 1 change

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAGreyhound USA18h 45m • 1 change

Departing Tuesday, November 17, 2026

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    Arrives next day

    Greyhound USAGreyhound USA18h 45m • 1 change

Frequently asked questions

Want to know about travelling from Key Largo to Jacksonville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key Largo to Jacksonville.ExpandLaunch map view
  • Distance: 473.8 mi
  • Duration: 18h 30m

What companies run services between Key Largo, FL, USA and Jacksonville, FL, USA?

You can take a bus from Key Largo Bus Stop to Jacksonville via Miami Airport Station in around 11h 30m.

Operators