The average bus between Key Largo and Anna Maria Island takes 20h 46m and the fastest bus takes 19h 21m. The bus service runs several times per day from Key Largo to Anna Maria Island. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Key Largo and Anna Maria Island. The earliest departure is at 12:55 PM in the afternoon, and the last departure from Key Largo is at 8:00 PM which arrives into Anna Maria Island at 3:21 PM. All services require a transfer at Miami Airport Station and take an average of 20h 46m. The schedules shown below are for the next available departures.
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19h 26m • 4 changesArrives next day




19h 21m • 4 changesArrives next day




19h 26m • 4 changesArrives next day




19h 21m • 4 changesWant to know about travelling from Key Largo to Anna Maria Island? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Key Largo to Anna Maria Island. However, there are services departing from Key Largo station and arriving at Anna Maria Island station via Miami Airport Station station. The journey, including transfers, takes approximately 20h 46m.
Key Largo to Anna Maria Island bus services, operated by Greyhound USA, depart from Key Largo Bus Stop station.
Key Largo to Anna Maria Island bus services, operated by Greyhound USA, arrive at Sarasota Cattlemen Transfer Center station.
The distance between Key Largo and Anna Maria Island is 352.3 km. The road distance is 524 km.
You can take a bus from Key Largo Bus Stop to Gulf Dr/42Nd St via Miami Airport Station, Sarasota Cattlemen Transfer Center, Cattlemen Transit Station, Downtown Transfer Station, 13Th St W @ 6Th Ave W Ns, and Downtown Station in around 10h 32m.