The average bus between Frederick and Durham takes 10h 5m and the fastest bus takes 8h 50m. The bus service runs several times per day from Frederick to Durham. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Frederick and Durham. The earliest departure is at 5:05 AM in the morning, and the last departure from Frederick is at 11:35 PM which arrives into Durham at 8:25 AM. All services require a transfer, and take on average 10h 5m. The schedules shown below are for the next available departures.

9h 30m • 1 change

11h 35m • 1 change
Arrives next day

8h 50m • 1 change

9h 30m • 1 change

11h 35m • 1 change
Arrives next day

8h 50m • 1 change

9h 30m • 1 change

11h 35m • 1 change
Arrives next day

8h 50m • 1 change

10h 50m • 1 change

11h 35m • 1 change
Arrives next day

8h 50m • 1 change
Want to know about travelling from Frederick to Durham? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frederick to Durham. However, there are services departing from Frederick station and arriving at Durham station via Washington Union Station station. The journey, including transfers, takes approximately 10h 5m.
Frederick to Durham bus services, operated by Greyhound USA, depart from Frederick Bus Station.
Frederick to Durham bus services, operated by Greyhound USA, arrive at Durham station.
Book your Frederick to Durham bus tickets online with Greyhound USA and Flixbus USA.
The distance between Frederick and Durham is 402.2 km. The road distance is 532 km.
You can take a bus from Frederick Bus Station to Durham via Washington Union Station in around 7h 55m.