What is the cheapest way to get from Des Moines to St. Louis?

The cheapest way to get from Des Moines to St. Louis is to drive which costs $60 - $90 and takes 6h 39m.

What is the fastest way to get from Des Moines to St. Louis?

The fastest way to get from Des Moines to St. Louis is to fly which takes 2h 5m and costs $170 - $1,200.

Is there a direct bus between Des Moines and St. Louis?

No, there is no direct bus from Des Moines to St. Louis station. However, there are services departing from Des Moines and arriving at St Louis Bus Station via Kansas City Bus Station. The journey, including transfers, takes approximately 8h 30m.

How far is it from Des Moines to St. Louis?

The distance between Des Moines and St. Louis is 282 miles. The road distance is 331.7 miles.

How do I travel from Des Moines to St. Louis without a car?

The best way to get from Des Moines to St. Louis without a car is to bus which takes 8h 30m and costs $50 - $150.

How long does it take to get from Des Moines to St. Louis?

It takes approximately 2h 5m to get from Des Moines to St. Louis, including transfers.

Where do I catch the Des Moines to St. Louis bus from?

Des Moines to St. Louis bus services, operated by Jefferson Lines, depart from Des Moines station.

Bus or fly from Des Moines to St. Louis?

The best way to get from Des Moines to St. Louis is to fly which takes 2h 5m and costs $170 - $1,200. Alternatively, you can bus, which costs $50 - $150 and takes 8h 30m.

Where does the Des Moines to St. Louis bus arrive?

Des Moines to St. Louis bus services, operated by Jefferson Lines, arrive at Kansas City station.

Can I drive from Des Moines to St. Louis?

Yes, the driving distance between Des Moines to St. Louis is 332 miles. It takes approximately 6h 39m to drive from Des Moines to St. Louis.

Where can I stay near St. Louis?

There are 345+ hotels available in St. Louis.

Des Moines to St. Louis - 4 ways to travel via train, plane, bus, and car

There are 4 ways to get from Des Moines to St. Louis by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly
best
1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane DSM - STL
2h 5m
$171–1,124
Bus, train
cheapest
1. Take the bus from Des Moines to Kansas Citybus Jefferson 803 / ...
2. Take the train from Kansas City to St. Louistrain Missouri River Runner / ...
10h 52m
$48–138
Bus
1. Take the bus from Des Moines to Kansas Citybus Jefferson 803 / ...
2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus Greyhound US0136 / ...
8h 30m
$53–148
Drive 329.8 mi
1. Drive from Des Moines to St. Louiscar 329.8 mi
6h 39m
$61–87

Des Moines to St. Louis by bus

14Weekly Buses

8h 30mAverage Duration

$53Cheapest Price

See schedules

Questions & Answers

Map of how to get from Des Moines to St. Louis.

Launch map view

Distance: 280 mi
Duration: 2h 5m

What companies run services between Des Moines, IA, USA and St. Louis, MO, USA?

Southwest Airlines flies from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) twice daily. Alternatively, you can take a bus from Des Moines to St Louis Bus Station via Kansas City Bus Station in around 8h 30m.

Airlines

Train operators

Bus operators

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