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Des Moines to Indianapolis buses

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Trip Overview

The bus between Des Moines and Indianapolis takes 9h 25m. There is at least one bus per day from Des Moines to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 25m
Duration
461 mi
Distance
$95
Average price
Once daily
Frequency

Des Moines to Indianapolis bus times

Buses run once daily between Des Moines and Indianapolis. The service departs Des Moines at 7:50 AM in the morning, which arrives into Indianapolis at 18:15:00. All services run direct with no transfers required, and take on average 9h 25m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    bus bus 9h 25m • Direct

Departing Monday, November 16, 2026

  •  → 

    bus bus 9h 25m • Direct

Departing Tuesday, November 17, 2026

  •  → 

    bus bus 9h 25m • Direct

Departing Wednesday, November 18, 2026

  •  → 

    bus bus 9h 25m • Direct

Departing Thursday, November 19, 2026

  •  → 

    bus bus 9h 25m • Direct

Departing Friday, November 20, 2026

  •  → 

    bus bus 9h 25m • Direct

Departing Saturday, November 21, 2026

  •  → 

    bus bus 9h 25m • Direct

Frequently asked questions

Want to know about travelling from Des Moines to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Indianapolis.ExpandLaunch map view
  • Distance: 461.4 mi
  • Duration: 9h 25m

What companies run services between Des Moines, IA, USA and Indianapolis, IN, USA?

Greyhound USA operates a bus from Des Moines to Indianapolis Union Station once daily. Tickets cost $80–130 and the journey takes 9h 25m.

Operators