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How to get fromDes Moines to Indianapolisby plane, bus (Greyhound, Flixbus), car, bus or train

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There are 5 ways to get from Des Moines to Indianapolis by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Indianapolis (IND)plane plane DSM - IND
    4h 51m
    $130–723
  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the bus from Chicago Bus Station to Indianapolisbus bus FlixBus N2640 / ...
    11h 55m
    $75–139
  3. Drive 465.7 mi

    1. Drive from Des Moines to Indianapoliscar car 465.7 mi
    7h 53m
    $85–123
  4. Drive to Fort Dodge Municipal Airport, fly

    1. Drive from Des Moines to Fort Dodge Municipal Airport (FOD)car car
    2. Fly from Fort Dodge Municipal Airport (FOD) to Indianapolis (IND)plane plane FOD - IND
    6h 44m
    $84–437
  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    13h 8m
    $94–199

Des Moines to Indianapolis by bus

Calendar19Weekly Buses
Duration11h 55mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Indianapolis, IN, USA?

American Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Des Moines to Indianapolis via Chicago Bus Station in around 11h 55m.

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