There are 8 ways to get from Depew to Manhattan by plane, train (Amtrak), bus, car, train, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Laguardia Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Laguardia Airport (LGA)plane BUF - LGA
2h 12m$110–623Bus
cheapest- Take the bus from Buffalo to New Yorkbus Adt N813 / ...
9h 54m$62–282Train (Amtrak)
- Take the train from Buffalo Depew Station to Ny Moynihan Train Hall At Penn Stationtrain Empire Service / ...
9h 5m$142–282Drive 351.4 mi
- Drive from Depew to Manhattancar 351.4 mi
7h 10m$65–93Fly to John F. Kennedy International Airport
- Fly from Buffalo Niagara International Airport (BUF) to John F. Kennedy International Airport (JFK)plane BUF - JFK
2h 12m$81–388Fly to Newark Liberty International Airport, train
- Fly from Buffalo Niagara International Airport (BUF) to Newark Liberty International Airport (EWR)plane BUF - EWR
- Take the train from Newark Airport Railroad Station to New York Penn Stationtrain
2h 18m$87–398Train via 86 St
- Take the train from Buffalo to New York Penn Stationtrain VIA Rail
10h 6m$115–285Bus via New York Midtown (Flixbus)
- Take the bus from Buffalo to New York Midtownbus FlixBus N2686 / ...
10h 34m$67–122
Depew to Manhattan by bus and train (Amtrak)
Questions & Answers
The cheapest way to get from Depew to Manhattan is to drive which costs $60 - $95 and takes 7h 10m.
The fastest way to get from Depew to Manhattan is to fly which takes 2h 12m and costs $80 - $390.
No, there is no direct bus from Depew to Manhattan. However, there are services departing from Broadway & Meridian Street and arriving at New York via Buffalo. The journey, including transfers, takes approximately 9h 54m.
No, there is no direct train from Depew station to Manhattan station. However, there are services departing from Buffalo Depew Station and arriving at Ny Moynihan Train Hall At Penn Station via . The journey, including transfers, takes approximately 9h 5m.
The distance between Depew and Manhattan is 305 miles. The road distance is 353.5 miles.
The best way to get from Depew to Manhattan without a car is to train which takes 9h 5m and costs $140 - $290.
It takes approximately 2h 12m to get from Depew to Manhattan, including transfers.
Depew to Manhattan bus services, operated by Trailways, depart from Buffalo station.
Depew to Manhattan train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Depew to Manhattan is to fly which takes 2h 12m and costs $110 - $650. Alternatively, you can train, which costs $140 - $290 and takes 9h 5m, you could also bus, which costs $60 - $290 and takes 9h 54m.
What companies run services between Depew, NY, USA and Manhattan, NY, USA?
American Airlines, Delta, and United Airlines fly from Buffalo Niagara International Airport (BUF) to Laguardia Airport (LGA) every 3 hours. Alternatively, Amtrak operates a train from Buffalo Depew Station to Ny Moynihan Train Hall At Penn Station 4 times a day. Tickets cost $140–280 and the journey takes 8h.
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Laguardia Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $90–600
Flights from Buffalo Niagara International Airport to John F. Kennedy International Airport
- Ave. Duration
- 1h 36m
- When
- Every day
- Estimated price
- $50–350
- Website
- united.com
Flights from Buffalo Niagara International Airport to Laguardia Airport via Washington Dulles
- Ave. Duration
- 3h 36m
- When
- Every day
- Estimated price
- $120–700
Flights from Buffalo Niagara International Airport to Newark Liberty International Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $50–350
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Laguardia Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $90–600
- Website
- jetblue.com
Flights from Buffalo Niagara International Airport to John F. Kennedy International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $50–350
Flights from Buffalo Niagara International Airport to John F. Kennedy International Airport via Boston
- Ave. Duration
- 3h 32m
- When
- Every day
- Estimated price
- $75–410
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Buffalo Depew Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 8h
- Frequency
- 4 times a day
- Estimated price
- $140–280
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 973-275-5555
- Website
- njtransit.com
Train from Newark Airport Railroad Station to New York Penn Station
- Ave. Duration
- 27 min
- Frequency
- Every 20 minutes
- Estimated price
- $15–19
- Website
- https://www.njtransit.com
- Website
- https://njtworldcup.com/
- Adult Airport
- $15–19
- Phone
- +1 888 842-7245
- Website
- viarail.ca
Train from Buffalo to New York Penn Station
- Ave. Duration
- 8h 46m
- Frequency
- Once daily
- Estimated price
- $110–280
- Website
- https://www.viarail.ca/en
- Escape
- $110–260
- Business
- $150–270
- Business Plus
- $160–280
- Economy
- $120–260
- Economy Plus
- $140–270
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Buffalo to New York
- Ave. Duration
- 7h 55m
- Frequency
- 5 times a day
- Estimated price
- $60–280
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $60–260
- Flexible
- $110–280
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Buffalo to New York Midtown
- Ave. Duration
- 8h 35m
- Frequency
- Every 4 hours
- Estimated price
- $65–120
- Schedules at
- flixbus.com
Want to know more about travelling around United States
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More Questions & Answers
Depew to Manhattan bus services, operated by Trailways, arrive at New York station.
Depew to Manhattan train services, operated by Amtrak, arrive at Ny Moynihan Train Hall At Penn Station.
Yes, the driving distance between Depew to Manhattan is 353 miles. It takes approximately 7h 10m to drive from Depew to Manhattan.
There are 3933+ hotels available in Manhattan.













