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Buffalo to Hyannis buses

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Trip Overview

The bus between Buffalo and Hyannis takes 12h 55m. There is at least one bus per day from Buffalo to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 55m
Duration
542 mi
Distance
$130
Average price
Once daily
Frequency

Buffalo to Hyannis bus times

Buses run once daily between Buffalo and Hyannis. The service departs Buffalo at 8:20 AM in the morning, which arrives into Hyannis at 21:15:00. All services require a transfer at Boston and take an average of 12h 55m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Greyhound USAPlymouth & Brockton12h 55m • 1 change

Departing Sunday, November 15, 2026

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    Greyhound USAPlymouth & Brockton12h 55m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Greyhound USAPlymouth & Brockton12h 55m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Greyhound USAPlymouth & Brockton12h 55m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    Greyhound USAPlymouth & Brockton12h 55m • 1 change

Departing Thursday, November 19, 2026

  •  → 

    Greyhound USAPlymouth & Brockton12h 55m • 1 change

Departing Friday, November 20, 2026

  •  → 

    Greyhound USAPlymouth & Brockton12h 55m • 1 change

Frequently asked questions

Want to know about travelling from Buffalo to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Hyannis.ExpandLaunch map view
  • Distance: 542.2 mi
  • Duration: 12h 55m

What companies run services between Buffalo, NY, USA and Hyannis, MA, USA?

You can take a bus from Buffalo to Hyannis Transportation Center via Boston and Boston South Buses in around 12h 37m.

Operators