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How to get fromBuffalo to Hyannisby plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

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There are 7 ways to get from Buffalo to Hyannis by plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barnstable Municipal Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Barnstable Municipal Airport (HYA)plane plane BUF - HYA
    4h 35m
    $81–478

  2. Bus

    1. Take the bus from Buffalo to Bostonbus bus Greyhound US0171
    2. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus Hyannis - South Shore to Logan Airport
    12h 37m
    $94–161

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Bostontrain train Lake Shore Limited
    2. Take the bus from Boston to Hyannisbus bus Bz 0956 / ...
    15h 28m
    $146–481

  4. Drive 512.7 mi

    1. Drive from Buffalo to Hyanniscar car 512.7 mi
    9h 3m
    $94–136

  5. Fly to Boston Logan Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Boston Logan Airport (BOS)plane plane BUF - BOS
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus
    5h 28m
    $89–428

  6. Fly to Provincetown Municipal Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Provincetown Municipal Airport (PVC)plane plane BUF - PVC
    2. Take the bus from Provincetown to Hyannisbus bus
    6h 51m
    $101–489

  7. Bus via Ithaca

    1. Take the bus from Buffalo to Ithacabus bus
    2. Take the bus from Ithaca to Bostonbus bus
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    15h 12m
    $100–162

Buffalo to Hyannis by bus

Calendar7Weekly Buses
Duration12h 37mAverage Duration
Ticket$94Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Hyannis.ExpandLaunch map view
  • Distance: 450.7 mi
  • Duration: 4h 35m

What companies run services between Buffalo, NY, USA and Hyannis, MA, USA?

JetBlue Airways, Cape Air, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Barnstable Municipal Airport (HYA) twice daily. Alternatively, you can take a bus from Buffalo to Hyannis Transportation Center via Boston and Boston South Buses in around 12h 37m.

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