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How to get fromBuffalo to Hyannisby plane, bus, train, car or bus (Flixbus, Greyhound)

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There are 7 ways to get from Buffalo to Hyannis by plane, bus, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barnstable Municipal Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Barnstable Municipal Airport (HYA)plane plane BUF - HYA
    4h 38m
    $134–880

  2. Bus via Buffalo, NY

    cheapest
    1. Take the bus from Buffalo, NY to Syracuse, NYbus bus
    2. Take the bus from Syracuse, NY to Boston, MAbus bus
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    13h 31m
    $78–161

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Bostontrain train Lake Shore Limited
    2. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus Boston
    15h 19m
    $99–485

  4. Drive 512.7 mi

    1. Drive from Buffalo to Hyanniscar car 512.7 mi
    9h 3m
    $94–136

  5. Fly to Boston Logan Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Boston Logan Airport (BOS)plane plane BUF - BOS
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus
    5h 30m
    $142–820

  6. Fly to Provincetown Municipal Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Provincetown Municipal Airport (PVC)plane plane BUF - PVC
    2. Take the bus from Provincetown Airport to Patriot Square, South Dennisbus bus
    18h 42m
    $320–1,986

  7. Bus

    1. Take the bus from Buffalo to Syracuse Bus Stationbus bus
    2. Take the bus from Syracuse Bus Station to Bostonbus bus
    3. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus
    14h 5m
    $82–234

Buffalo to Hyannis by train and bus

Calendar7Weekly Services
Duration15h 19mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and Hyannis, MA, USA?

American Airlines, JetBlue Airways, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Barnstable Municipal Airport (HYA) 5 times a day. Alternatively, you can take a bus from Ellicott Street & East Huron Street to Hyannis Transportation Center via Buffalo, NY, Syracuse, NY, Boston, MA, Prudential, Boylston, and Boston South Buses in around 13h 31m.

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