The average bus between Manhattan and Hyannis takes 6h 51m and the fastest bus takes 6h 15m. The bus service runs several times per day from Manhattan to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Manhattan and Hyannis. The earliest departure is at 1:30 AM at night, and the last departure from Manhattan is at 7:00 PM which arrives into Hyannis at 1:35 AM. All services require a transfer at Boston and take an average of 6h 51m. The schedules shown below are for the next available departures.

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6h 15m • 1 changeWant to know about travelling from Manhattan to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manhattan to Hyannis. However, there are services departing from New York Midtown station and arriving at Hyannis Transportation Center station via Boston station. The journey, including transfers, takes approximately 6h 51m.
Manhattan to Hyannis bus services, operated by Flixbus USA, depart from New York Midtown station.
Manhattan to Hyannis bus services, operated by Plymouth & Brockton, arrive at Hyannis Transportation Center station.
Book your Manhattan to Hyannis bus tickets online with Omio.
The distance between Manhattan and Hyannis is 322.9 km. The road distance is 388 km.
You can take a bus from New York Midtown to Hyannis Transportation Center via Boston and Boston South Buses in around 6h 52m.