The average bus between Boston and Des Moines takes 44h 53m and the fastest bus takes 41h 15m. The bus service runs several times per day from Boston to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Boston and Des Moines. The earliest departure is at 1:00 AM at night, and the last departure from Boston is at 3:00 PM which arrives into Des Moines at 2:35 PM. All services require a transfer at New York Midtown and take an average of 44h 53m. The schedules shown below are for the next available departures.
Arrives next day


40h 15m • 2 changes
Arrives +2 days


47h 35m • 2 changes
Arrives next day


41h 45m • 2 changes
Arrives +2 days


47h 35m • 2 changes
Arrives next day


41h 45m • 2 changes
Arrives +2 days


47h 35m • 2 changes
Arrives next day


40h 15m • 2 changes
Arrives +2 days


47h 35m • 2 changes
Want to know about travelling from Boston to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Boston to Des Moines. However, there are services departing from Boston station and arriving at Des Moines station via New York Midtown. The journey, including transfers, takes approximately 44h 53m.
Boston to Des Moines bus services, operated by Flixbus USA, depart from Boston station.
Boston to Des Moines bus services, operated by Flixbus USA, arrive at Des Moines station.
Book your Boston to Des Moines bus tickets online with Flixbus USA and Greyhound USA.
The distance between Boston and Des Moines is 1,860.4 km. The road distance is 2,306 km.
You can take a bus from Boston to Des Moines via New York Midtown and Chicago Bus Station in around 29h 45m.