There are 7 ways to get from Topeka to Tupelo by bus (Greyhound, Flixbus), train, bus, car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via St. Louis
best- Take the bus from Topeka to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
14h 49m$113–216Drive to Manhattan Regional Airport, fly to Golden Triangle Regional Airport, drive
cheapest- Drive from Topeka to Manhattan Regional Airport (MHK)car
- Fly from Manhattan Regional Airport (MHK) to Golden Triangle Regional Airport (GTR)plane MHK - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
9h 58m$108–474Train, bus
- Take the train from Topeka Station to Kansas Citytrain
- Take the train from Kansas City to St. Louistrain
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
17h 15m$171–361Drive 599.8 mi
- Drive from Topeka to Tupelocar 599.8 mi
10h 48m$110–159Bus
- Take the bus from Quincy Street Station - Topeka to 2745 Southwest Blvd - Kansas Citybus
- Take the bus from Kansas City to Tulsabus
- Take the bus from Tulsa to Memphisbus
- Take the bus from Memphis Bus Station to Tupelobus
19h 53m$229–337Drive to Manhattan Regional Airport, fly to Tupelo Regional Airport
- Drive from Topeka to Manhattan Regional Airport (MHK)car
- Fly from Manhattan Regional Airport (MHK) to Tupelo Regional Airport (TUP)plane MHK - TUP
8h 13m$121–485Bus to Kansas City, fly to Golden Triangle Regional Airport, drive
- Take the bus from Quincy Street Station - Topeka to 2745 Southwest Blvd - Kansas Citybus
- Fly from Kansas City (MCI) to Golden Triangle Regional Airport (GTR)plane MCI - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
9h 11m$174–671
Manhattan Regional Airport (MHK) to Golden Triangle Regional Airport (GTR) flights
Comparing Your Travel Options
The cheapest way to get from Topeka to Tupelo is to drive which costs $100 - $160 and takes 10h 48m.
The fastest way to get from Topeka to Tupelo is to drive and fly which takes 8h 13m and costs $120 - $490.
No, there is no direct bus from Topeka to Tupelo. However, there are services departing from Topeka and arriving at Tupelo via St Louis Bus Station and Memphis Bus Station. The journey, including transfers, takes approximately 14h 49m.
The distance between Topeka and Tupelo is 709 miles. The road distance is 603.3 miles.
The best way to get from Topeka to Tupelo without a car is to bus via St. Louis which takes 14h 49m and costs $110 - $220.
It takes approximately 14h 49m to get from Topeka to Tupelo, including transfers.
Topeka to Tupelo bus services, operated by Greyhound USA, depart from Topeka station.
Topeka to Tupelo bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Yes, the driving distance between Topeka to Tupelo is 603 miles. It takes approximately 10h 48m to drive from Topeka to Tupelo.
Book your Topeka to Tupelo bus tickets online with Omio.
What companies run services between Topeka, KS, USA and Tupelo, MS, USA?
You can take a bus from Topeka to Tupelo via St Louis Bus Station, Memphis Bus Station, and Tupelo in around 14h 49m.
- Website
- delta.com
Flights from Manhattan Regional Airport to Golden Triangle Regional Airport via Dallas/Ft.Worth, Atlanta
- Ave. Duration
- 7h 42m
- When
- Every day
- Estimated price
- $120–550
Flights from Kansas City to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $120–600
- Website
- contouraviation.com
Flights from Manhattan Regional Airport to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 41m
- When
- Every day
- Estimated price
- $220–850
Flights from Manhattan Regional Airport to Tupelo Regional Airport via Chicago O'Hare, Nashville
- Ave. Duration
- 11h 33m
- When
- Sunday
- Estimated price
- $95–450
Flights from Manhattan Regional Airport to Tupelo Regional Airport via Chicago O'Hare, Dallas/Ft.Worth
- Ave. Duration
- 11h 33m
- When
- Monday to Saturday
- Estimated price
- $140–600
Flights from Manhattan Regional Airport to Tupelo Regional Airport via Dallas/Ft.Worth, Nashville
- Ave. Duration
- 12h 45m
- When
- Sunday
- Estimated price
- $100–480
- Website
- aa.com
Flights from Manhattan Regional Airport to Golden Triangle Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 9h 14m
- When
- Every day
- Estimated price
- $85–440
Flights from Kansas City to Golden Triangle Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 25m
- When
- Every day
- Estimated price
- $120–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Topeka Station to Kansas City
- Ave. Duration
- 2h 1m
- Frequency
- Once daily
- Estimated price
- $20–45
- Website
- Amtrak
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $85–190
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Topeka to St Louis Bus Station
- Ave. Duration
- 6h 15m
- Frequency
- Twice daily
- Estimated price
- $45–90
- Website
- Greyhound
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $40–85
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–29
- Website
- Greyhound
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $40–85
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–29
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–29
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $40–75
- Schedules at
- Flixbus USA
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $40–75
- Schedules at
- Flixbus USA
- Phone
- +1 800-923-1799
- contactus@omexusa.net
- Website
- Omnibus Express
Bus from Quincy Street Station - Topeka to 2745 Southwest Blvd - Kansas City
- Ave. Duration
- 51 min
- Frequency
- Once daily
- Estimated price
- $40–55
- Schedules at
- Omnibus Express
Bus from Quincy Street Station - Topeka to 2745 Southwest Blvd - Kansas City
- Ave. Duration
- 51 min
- Frequency
- Once daily
- Estimated price
- $40–55
- Schedules at
- Omnibus Express
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Kansas City to Tulsa
- Ave. Duration
- 4h 55m
- Frequency
- Once daily
- Estimated price
- $60–90
- Book at
- Jefferson Lines
- Adult
- $60–90
Bus from Tulsa to Memphis
- Ave. Duration
- 8h 35m
- Frequency
- 4 times a week
- Estimated price
- $100–150
- Book at
- Jefferson Lines
- Adult
- $100–150
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Booking & Getting There
There are 31+ hotels available in Tupelo.














