Rome2Rio

How to get fromKey West to Tupeloby plane, car, shuttle, bus or bus (Greyhound, Flixbus)

Find Transport to Tupelo

See all options

There are 7 ways to get from Key West to Tupelo by plane, car, shuttle, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Golden Triangle Regional Airport, drive

    best
    1. Fly from Key West International Airport (EYW) to Golden Triangle Regional Airport (GTR)plane plane EYW - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    8h 4m
    $123–581

  2. Shuttle, bus

    1. Take a shuttle bus from Key West, FL to Miami, FL - International Airportshuttle bus
    2. Take the bus from Miami Airport to Orlando - RedCoach Station, FLbus bus
    3. Take the bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tupelobus bus
    25h 10m
    $411–651

  3. Drive 1,009.1 mi

    1. Drive from Key West to Tupelocar car 1,009.1 mi
    19h 4m
    $185–266

  4. Fly to Birmingham–Shuttlesworth International Airport, drive

    1. Fly from Key West International Airport (EYW) to Birmingham–Shuttlesworth International Airport (BHM)plane plane EYW - BHM
    2. Drive from Birmingham-Airport-BHM to Tupelocar car
    6h 19m
    $226–1,054

  5. Fly to Huntsville International Airport-Carl T Jones Field, drive

    1. Fly from Key West International Airport (EYW) to Huntsville International Airport-Carl T Jones Field (HSV)plane plane EYW - HSV
    2. Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Tupelocar car
    6h 52m
    $155–749

  6. Fly to Memphis, bus

    1. Fly from Key West International Airport (EYW) to Memphis (MEM)plane plane EYW - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    8h 4m
    $191–914

  7. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tupelobus bus
    26h 51m
    $170–373

Key West International Airport (EYW) to Golden Triangle Regional Airport (GTR) flights

Calendar21Weekly Planes
Duration8h 45mAverage Duration
Ticket$100Cheapest Price
See schedules

Questions & Answers

What companies run services between Key West, FL, USA and Tupelo, MS, USA?

You can take a bus from N Roosevelt & 3rd Street to Tupelo via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, and Tupelo in around 26h 51m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Key West

Trips to Tupelo

Popular routes