There are 7 ways to get from Key West to Tupelo by plane, car, shuttle, bus, bus (Greyhound), or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Golden Triangle Regional Airport, drive
best- Fly from Key West International Airport (EYW) to Golden Triangle Regional Airport (GTR)EYW - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelo
7h 21m$108–471Shuttle, bus
- Take a shuttle bus from Key West, FL to Miami, FL - International Airport
- Take the bus from Miami Airport to Orlando - RedCoach Station, FL
- Take the bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Station
- Take the bus from Atlanta Bus Station to Tupelo
25h$289–549Drive 1,009 mi
- Drive from Key West to Tupelo1,009 mi
18h 53m$185–266Fly to Birmingham–Shuttlesworth International Airport, drive
- Fly from Key West International Airport (EYW) to Birmingham–Shuttlesworth International Airport (BHM)EYW - BHM
- Drive from Birmingham-Airport-BHM to Tupelo
6h 23m$166–754Fly to Huntsville International Airport-Carl T Jones Field, drive
- Fly from Key West International Airport (EYW) to Huntsville International Airport-Carl T Jones Field (HSV)EYW - HSV
- Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Tupelo
7h 13m$145–649Bus
- Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30Lks
- Take the bus from Big Pine Key to Miami Airport Station
- Take the bus from Miami Airport Station to Atlanta Bus Station
- Take the bus from Atlanta Bus Station to Tupelo
26h 40m$167–381Bus, train
- Take the bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30Lks
- Take the bus from Big Pine Key to Miami Airport Station
- Take the train from Miami Amtrak Station to Savannah Station
- Take the bus from Savannah Bus Station to Atlanta Bus Station
- Take the bus from Atlanta Bus Station to Tupelo
30h 18m$269–640
Key West International Airport (EYW) to Golden Triangle Regional Airport (GTR) flights
Questions & Answers
The cheapest way to get from Key West to Tupelo is to drive which costs $180 - $270 and takes 18h 53m.
The fastest way to get from Key West to Tupelo is to fly and drive which takes 6h 23m and costs $160 - $800.
The distance between Key West and Tupelo is 809 miles. The road distance is 1014.9 miles.
The best way to get from Key West to Tupelo without a car is to shuttle and bus which takes 25h and costs $280 - $550.
It takes approximately 7h 21m to get from Key West to Tupelo, including transfers.
Tupelo is 1h behind Key West. It is currently 8:17 PM in Key West and 7:17 PM in Tupelo.
Yes, the driving distance between Key West to Tupelo is 1015 miles. It takes approximately 18h 53m to drive from Key West to Tupelo.
There are 33+ hotels available in Tupelo.
What companies run services between Key West, FL, USA and Tupelo, MS, USA?
You can take a bus from N Roosevelt & 3rd Street to Tupelo via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, and Tupelo in around 26h 40m.
- Website
- delta.com
Flights from Key West International Airport to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 8h 36m
- When
- Every day
- Estimated price
- $85–440
Flights from Key West International Airport to Birmingham–Shuttlesworth International Airport via Atlanta
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $130–700
Flights from Key West International Airport to Huntsville International Airport-Carl T Jones Field via Atlanta
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $110–600
- Website
- aa.com
Flights from Key West International Airport to Birmingham–Shuttlesworth International Airport via Miami
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $130–700
Flights from Key West International Airport to Birmingham–Shuttlesworth International Airport via Charlotte
- Ave. Duration
- 5h 31m
- When
- Every day
- Estimated price
- $170–800
Flights from Key West International Airport to Birmingham–Shuttlesworth International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 32m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $230–1,000
Flights from Key West International Airport to Huntsville International Airport-Carl T Jones Field via Miami
- Ave. Duration
- 6h 37m
- When
- Saturday
- Estimated price
- $110–600
Flights from Key West International Airport to Huntsville International Airport-Carl T Jones Field via Charlotte
- Ave. Duration
- 6h 39m
- When
- Every day
- Estimated price
- $130–650
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Miami Amtrak Station to Savannah Station
- Ave. Duration
- 11h 27m
- Frequency
- Twice daily
- Estimated price
- $100–270
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Key West, FL to Miami, FL - International Airport
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $150–210
- Website
- https://www.keysshuttle.com
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Miami Airport to Orlando - RedCoach Station, FL
- Ave. Duration
- 3h 40m
- Frequency
- Every 4 hours
- Estimated price
- $24–80
- Website
- https://www.redcoachusa.com
- Web
- $24–80
Bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Station
- Ave. Duration
- 7h 15m
- Frequency
- Twice daily
- Estimated price
- $40–110
- Website
- https://www.redcoachusa.com
- Web
- $40–110
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Atlanta Bus Station to Tupelo
- Ave. Duration
- 5h 45m
- Frequency
- Twice daily
- Estimated price
- $60–130
- Website
- https://www.greyhound.com/
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Atlanta Bus Station
- Ave. Duration
- 13h 15m
- Frequency
- Once daily
- Estimated price
- $65–170
- Website
- https://www.greyhound.com/
Bus from Savannah Bus Station to Atlanta Bus Station
- Ave. Duration
- 5h 25m
- Frequency
- Once daily
- Estimated price
- $40–120
- Website
- https://www.greyhound.com/
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 54 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
Bus from N Roosevelt & 4th Street to Big Pine Key - Auto Store / NAPA MM30
- Ave. Duration
- 53 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Savannah Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h 11m
- Frequency
- 3 times a day
- Estimated price
- $35–120
- Schedules at
- flixbus.com
- Phone
- +1 404-591-2750
- info@southeasternstages.com
- Website
- southeasternstages.com
Bus from Savannah Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- $65–110
- Schedules at
- southeasternstages.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide














