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How to get fromKey West to Tupeloby plane, car, bus (Greyhound, Flixbus), or bus

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There are 6 ways to get from Key West to Tupelo by plane, car, bus (Greyhound, Flixbus), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Golden Triangle Regional Airport, drive

    best
    1. Fly from Key West International Airport (EYW) to Golden Triangle Regional Airport (GTR)plane plane EYW - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    6h 24m
    $102–459

  2. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tupelobus bus
    26h 36m
    $186–308

  3. Drive  1,009.1 mi

    1. Drive from Key West to Tupelocar car 1,009.1 mi
    19h 4m
    $167–241

  4. Fly to Birmingham–Shuttlesworth International Airport, drive

    1. Fly from Key West International Airport (EYW) to Birmingham–Shuttlesworth International Airport (BHM)plane plane EYW - BHM
    2. Drive from Birmingham-Airport-BHM to Tupelocar car
    6h 49m
    $109–459

  5. Fly to Huntsville International Airport-Carl T Jones Field, drive

    1. Fly from Key West International Airport (EYW) to Huntsville International Airport-Carl T Jones Field (HSV)plane plane EYW - HSV
    2. Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Tupelocar car
    7h 9m
    $107–459

  6. Fly to Memphis, bus

    1. Fly from Key West International Airport (EYW) to Memphis (MEM)plane plane EYW - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    8h 17m
    $202–906

Key West International Airport (EYW) to Golden Triangle Regional Airport (GTR) flights

Calendar21Weekly Planes
Duration7h 16mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Key West to Tupelo.ExpandLaunch map view
  • Distance: 804.2 mi
  • Duration: 6h 24m

What companies run services between Key West, FL, USA and Tupelo, MS, USA?

You can take a bus from N Roosevelt & 3rd Street to Tupelo via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, and Tupelo in around 26h 36m.

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Bus operators

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