There are 4 ways to get from St. Louis to Tupelo by bus (Greyhound, Flixbus), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from St Louis Bus Station to Memphis Bus Stationbus Greyhound US1173
- Take the bus from Memphis Bus Station to Tupelobus Greyhound US0610
8h 14m$82–211Drive 368.6 mi
cheapest- Drive from St. Louis to Tupelocar 368.6 mi
6h 30m$68–98Fly to Golden Triangle Regional Airport, drive
- Fly from Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR)plane STL - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
6h 47m$124–620Fly to Tupelo Regional Airport
- Fly from Lambert–St. Louis International Airport (STL) to Tupelo Regional Airport (TUP)plane STL - TUP
5h 39m$138–772
Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR) flights
Questions & Answers
The cheapest way to get from St. Louis to Tupelo is to drive which costs $65 - $100 and takes 6h 30m.
The fastest way to get from St. Louis to Tupelo is to fly which takes 5h 39m and costs $130 - $800.
The distance between St. Louis and Tupelo is 398 miles. The road distance is 370.7 miles.
The best way to get from St. Louis to Tupelo without a car is to bus which takes 8h 14m and costs $80 - $220.
It takes approximately 8h 14m to get from St. Louis to Tupelo, including transfers.
The best way to get from St. Louis to Tupelo is to bus which takes 8h 14m and costs $80 - $220. Alternatively, you can fly, which costs $130 - $800 and takes 5h 39m.
Yes, the driving distance between St. Louis to Tupelo is 371 miles. It takes approximately 6h 30m to drive from St. Louis to Tupelo.
There are 33+ hotels available in Tupelo.
What companies run services between St. Louis, MO, USA and Tupelo, MS, USA?
You can take a bus from St Louis Bus Station to Tupelo via Memphis Bus Station and Tupelo in around 8h 14m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Tupelo Regional Airport (TUP) twice daily.
- Website
- contouraviation.com
Flights from Lambert–St. Louis International Airport to Tupelo Regional Airport via Nashville
- Ave. Duration
- 4h 30m
- When
- Friday to Sunday
- Estimated price
- $120–750
Flights from Lambert–St. Louis International Airport to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 55m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Lambert–St. Louis International Airport to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 6h 15m
- When
- Tuesday
- Estimated price
- $170–900
Flights from Lambert–St. Louis International Airport to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 8h 46m
- When
- Sunday
- Estimated price
- $170–900
Flights from Lambert–St. Louis International Airport to Tupelo Regional Airport via Kansas City, Nashville
- Ave. Duration
- 9h
- When
- Sunday
- Estimated price
- $180–900
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $110–600
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Golden Triangle Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 58m
- When
- Monday, Thursday, and Friday
- Estimated price
- $130–700
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $50–65
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $22–65
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- 5 times a week
- Estimated price
- $50–140
- Schedules at
- flixbus.com
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