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How to get fromSt. Louis to Tupeloby bus (Flixbus, Greyhound), car, plane, or bus

Find Transport to Tupelo

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There are 5 ways to get from St. Louis to Tupelo by bus (Flixbus, Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus FlixBus 2510
    2. Take the bus from Memphis Bus Station to Tupelobus bus Greyhound US0610
    7h 34m
    $71–126

  2. Drive 368.5 mi

    cheapest
    1. Drive from St. Louis to Tupelocar car 368.5 mi
    6h 23m
    $68–98

  3. Fly to Golden Triangle Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR)plane plane STL - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    7h
    $108–520

  4. Fly to Tupelo Regional Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Tupelo Regional Airport (TUP)plane plane STL - TUP
    7h 19m
    $86–450

  5. Fly to Memphis, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Memphis (MEM)plane plane STL - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    8h 43m
    $150–796

Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR) flights

Calendar34Weekly Planes
Duration4h 44mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Tupelo.ExpandLaunch map view
  • Distance: 393.7 mi
  • Duration: 7h 34m

What companies run services between St. Louis, MO, USA and Tupelo, MS, USA?

You can take a bus from St Louis Bus Station to Tupelo via Memphis Bus Station and Tupelo in around 7h 34m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Tupelo Regional Airport (TUP) 4 times a day.

Airlines
Bus operators

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