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How to get fromSt. Louis to Tupeloby bus (Greyhound, Flixbus), car, plane, or bus

Find Transport to Tupelo

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There are 5 ways to get from St. Louis to Tupelo by bus (Greyhound, Flixbus), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus Greyhound US1173
    2. Take the bus from Memphis Bus Station to Tupelobus bus Greyhound US0610
    8h 19m
    $71–113

  2. Drive  368.5 mi

    cheapest
    1. Drive from St. Louis to Tupelocar car 368.5 mi
    6h 23m
    $68–98

  3. Fly to Golden Triangle Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR)plane plane STL - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    6h 17m
    $94–480

  4. Fly to Tupelo Regional Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Tupelo Regional Airport (TUP)plane plane STL - TUP
    5h 39m
    $96–520

  5. Fly to Memphis, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Memphis (MEM)plane plane STL - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    9h 28m
    $160–844

Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR) flights

Calendar23Weekly Planes
Duration5h 1mAverage Duration
Ticket$84Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Tupelo.ExpandLaunch map view
  • Distance: 395.1 mi
  • Duration: 8h 19m

What companies run services between St. Louis, MO, USA and Tupelo, MS, USA?

You can take a bus from St Louis Bus Station to Tupelo via Memphis Bus Station and Tupelo in around 8h 19m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Tupelo Regional Airport (TUP) once daily.

Airlines
Bus operators

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