Rome2Rio

How to get fromCape Cod to Buffaloby bus, plane, bus (Greyhound, Flixbus), train or car

Find Transport to Buffalo

See all options

There are 8 ways to get from Cape Cod to Buffalo by bus, plane, bus (Greyhound, Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 59m
    $176–971

  2. Bus

    cheapest
    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    14h 6m
    $83–183

  3. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus Hyannis - South Shore to Logan Airport
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 9m
    $144–292

  4. Drive 517.1 mi

    1. Drive from Cape Cod to Buffalocar car 517.1 mi
    9h 8m
    $95–137

  5. Fly Barnstable Municipal Airport to Buffalo Niagara International Airport

    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)plane plane HYA - BUF
    8h 58m
    $221–1,434

  6. Bus to Provincetown Municipal Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Theophilus F. Smith Road to Race Point Beachbus bus
    2. Fly from Provincetown Municipal Airport (PVC) to Buffalo Niagara International Airport (BUF)plane plane PVC - BUF
    8h 44m
    $151–984

  7. Bus to Boston Logan Airport, fly to Rochester, bus

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 7m
    $257–737

  8. Bus via New York

    1. Take the bus from Hyannis Transportation Center to Providence Bus Terminalbus bus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Buffalobus bus
    17h 14m
    $99–378

Cape Cod to Buffalo by bus

Calendar28Weekly Buses
Duration17h 14mAverage Duration
Ticket$99Cheapest Price
See schedules

Questions & Answers

What companies run services between Cape Cod, MA, USA and Buffalo, NY, USA?

You can take a bus from Town Hall Lawton Bus Shelter to Buffalo via Hyannis Transportation Center, Boston, Bus Terminal South Station, Boston, and Syracuse Bus Station in around 14h 6m. Alternatively, American Airlines, Cape Air, and JetBlue Airways fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) every 4 hours.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Where to next?

Trips from Cape Cod

Trips to Buffalo

Popular routes