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How to get fromCape Cod to Buffaloby bus (Greyhound, Flixbus), bus, train, car or plane

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There are 8 ways to get from Cape Cod to Buffalo by bus (Greyhound, Flixbus), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    14h 4m
    $84–188

  2. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus Hyannis - South Shore to Logan Airport
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 10m
    $154–322

  3. Drive 517.1 mi

    1. Drive from Cape Cod to Buffalocar car 517.1 mi
    9h 8m
    $95–137

  4. Fly Barnstable Municipal Airport to Buffalo Niagara International Airport

    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)plane plane HYA - BUF
    8h 47m
    $228–1,408

  5. Bus via New York

    1. Take the bus from Hyannis Transportation Center to Providence Bus Terminalbus bus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Buffalobus bus
    17h 14m
    $113–408

  6. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 43m
    $163–895

  7. Bus to Provincetown Municipal Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Theophilus F. Smith Road to Race Point Beachbus bus
    2. Fly from Provincetown Municipal Airport (PVC) to Buffalo Niagara International Airport (BUF)plane plane PVC - BUF
    8h 25m
    $148–908

  8. Bus to Boston Logan Airport, fly to Rochester, bus

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 7m
    $257–838

Cape Cod to Buffalo by bus

Calendar12Weekly Buses
Duration14h 4mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

What companies run services between Cape Cod, MA, USA and Buffalo, NY, USA?

You can take a bus from Town Hall Lawton Bus Shelter to Buffalo via Hyannis Transportation Center, Boston, Bus Terminal South Station, Boston, and Syracuse Bus Station in around 14h 4m. Alternatively, Cape Air, JetBlue Airways, and American Airlines fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) every 4 hours.

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