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How to get fromCape Cod to Buffaloby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 7 ways to get from Cape Cod to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Barnstable Municipal Airport to Buffalo Niagara International Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)plane plane HYA - BUF
    8h 11m
    $190–1,286

  2. Drive 517.1 mi

    cheapest
    1. Drive from Cape Cod to Buffalocar car 517.1 mi
    9h 8m
    $95–137

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    14h 9m
    $106–243

  4. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus Hyannis - South Shore to Logan Airport
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 9m
    $124–372

  5. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    7h
    $155–923

  6. Bus to Provincetown Municipal Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Theophilus F. Smith Road to Race Point Beachbus bus
    2. Fly from Provincetown Municipal Airport (PVC) to Buffalo Niagara International Airport (BUF)plane plane PVC - BUF
    9h 34m
    $140–936

  7. Bus to Boston Logan Airport, fly to Rochester, bus

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester, NY to Buffalo, NYbus bus
    8h 57m
    $245–778

Cape Cod to Buffalo by bus

Calendar12Weekly Buses
Duration14h 9mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

What companies run services between Cape Cod, MA, USA and Buffalo, NY, USA?

Cape Air, JetBlue Airways, and American Airlines fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) 5 times a day. Alternatively, you can take a bus from Town Hall Lawton Bus Shelter to Buffalo via Hyannis Transportation Center, Boston, Bus Terminal South Station, Boston, and Syracuse Bus Station in around 14h 9m.

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