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How to get fromCape Cod to Buffaloby bus, plane, bus (Flixbus, Greyhound), train or car

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There are 7 ways to get from Cape Cod to Buffalo by bus, plane, bus (Flixbus, Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly

    best
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)planeBOS - BUF
    6h 35m
    $193–1,045

  2. Drive 517.1 mi

    cheapest
    1. Drive from Cape Cod to Buffalocar517.1 mi
    9h 5m
    $95–137

  3. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus
    2. Take the bus from Boston to Syracuse Bus Stationbus
    3. Take the bus from Syracuse Bus Station to Buffalobus
    14h 8m
    $105–283

  4. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South BusesbusHyannis - South Shore to Logan Airport
    2. Take the train from Boston to Buffalo Depew StationtrainLake Shore Limited
    17h 9m
    $129–352

  5. Fly from Barnstable Municipal Airport

    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)planeHYA - BUF
    7h 15m
    $208–1,308

  6. Bus to Provincetown Municipal Airport, fly

    1. Take the bus from Patriot Square, South Dennis to MacMillan Pier, Provincetownbus
    2. Fly from Provincetown Municipal Airport (PVC) to Buffalo Niagara International Airport (BUF)planePVC - BUF
    9h 33m
    $201–1,211

  7. Bus via New York

    1. Take the bus from Hyannis Transportation Center to Providence Bus Terminalbus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus
    3. Take the bus from New York to Buffalobus
    17h 14m
    $99–378

Cape Cod to Buffalo by bus

Calendar16Weekly Buses
Duration14h 8mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

What companies run services between Cape Cod, MA, USA and Buffalo, NY, USA?

You can take a bus from Town Hall Lawton Bus Shelter to Buffalo via Hyannis Transportation Center, Boston, Bus Terminal South Station, Boston, and Syracuse Bus Station in around 14h 8m. Alternatively, JetBlue Airways, Cape Air, and American Airlines fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) 4 times a day.

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