There are 10 ways to get from Santa Rosa to Knoxville by plane, bus, train, bus (Greyhound), car, or subway
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Sonoma County Airport to Mcghee Tyson Airport
best- Fly from Sonoma County Airport (STS) to Mcghee Tyson Airport (TYS)plane STS - TYS
8h 6m$321–1,225Train, bus to San Francisco International Airport, fly to Nashville, drive
cheapest- Take the train from SMART Santa Rosa Downtown to SMART Larkspurtrain
- Take the bus from Larkspur - pickup to San Francisco Airportbus
- Fly from San Francisco International Airport (SFO) to Nashville (BNA)plane SFO - BNA
- Drive from Nashville-Airport-BNA to Knoxvillecar
10h 46m$273–559Bus, train
- Take the bus from Santa Rosa Amtrak Bus Stop to Martinezbus
- Take the train from Martinez to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain
- Take the bus from New York to Knoxvillebus
3d 17hBus
- Take the bus from Santa Rosa to Phoenix Bus Stationbus
- Take the bus from Phoenix Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus
- Take the bus from New York to Knoxvillebus
3d 19h$656–999Drive 2,508.6 mi
- Drive from Santa Rosa to Knoxvillecar 2,508.6 mi
40h 9m$458–662Train, bus to San Francisco International Airport, fly to Mcghee Tyson Airport
- Take the train from SMART Santa Rosa Downtown to SMART Larkspurtrain
- Take the bus from Larkspur - pickup to San Francisco Airportbus
- Fly from San Francisco International Airport (SFO) to Mcghee Tyson Airport (TYS)plane SFO - TYS
10h 14m$338–1,209Train, bus to Oakland International Airport, fly to Mcghee Tyson Airport
- Take the train from SMART Santa Rosa Downtown to SMART San Rafaeltrain
- Take the bus from San Rafael to Oakland International Airportbus
- Fly from Oakland International Airport (OAK) to Mcghee Tyson Airport (TYS)plane OAK - TYS
10h 37m$381–1,431Train, BART to Norman Y. Mineta San José International Airport, fly to Mcghee Tyson Airport
- Take the train from SMART Santa Rosa Downtown to SMART San Rafaeltrain
- Take the subway from El Cerrito Del Norte to Milpitassubway
- Fly from Norman Y. Mineta San José International Airport (SJC) to Mcghee Tyson Airport (TYS)plane SJC - TYS
11h 56m$362–1,399Train, train to Sacramento International Airport, fly to Mcghee Tyson Airport
- Take the train from SMART Santa Rosa Downtown to SMART San Rafaeltrain
- Take the train from Richmond to Sacramentotrain
- Fly from Sacramento International Airport (SMF) to Mcghee Tyson Airport (TYS)plane SMF - TYS
13h 18m$395–1,461Bus, train via Chicago
- Take the bus from Santa Rosa Amtrak Bus Stop to Martinezbus
- Take the train from Martinez to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to New York Midtownbus
- Take the bus from New York to Knoxvillebus
3d 17h
Sonoma County Airport (STS) to Mcghee Tyson Airport (TYS) flights
Comparing Your Travel Options
The cheapest way to get from Santa Rosa to Knoxville is to train and bus and fly and drive which costs $270 - $600 and takes 10h 46m.
The fastest way to get from Santa Rosa to Knoxville is to fly which takes 8h 6m and costs $320 - $1,300.
No, there is no direct bus from Santa Rosa to Knoxville. However, there are services departing from Santa Rosa and arriving at Knoxville via Phoenix Bus Station, St Louis Bus Station and New York. The journey, including transfers, takes approximately 3 days 19h.
The distance between Santa Rosa and Knoxville is 2164 miles. The road distance is 2523.2 miles.
The best way to get from Santa Rosa to Knoxville without a car is to bus and train which takes 3 days 17h and costs .
It takes approximately 8h 6m to get from Santa Rosa to Knoxville, including transfers.
Santa Rosa to Knoxville bus services, operated by ACN Autobuses, depart from Santa Rosa station.
The best way to get from Santa Rosa to Knoxville is to fly which takes 8h 6m and costs $320 - $1,300. Alternatively, you can bus, which costs $650 - $1,000 and takes 3 days 19h.
Santa Rosa to Knoxville bus services, operated by ACN Autobuses, arrive at Phoenix Bus Station.
Knoxville is 3h ahead of Santa Rosa. It is currently 11:56 PM in Santa Rosa and 2:56 AM in Knoxville.
What companies run services between Santa Rosa, CA, USA and Knoxville, TN, USA?
American Airlines, Southwest Airlines, and two other airlines fly from Sonoma County Airport (STS) to Mcghee Tyson Airport (TYS) once daily. Alternatively, you can take a bus from Santa Rosa to Knoxville via Phoenix Bus Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 19h.
- Website
- southwest.com
Flights from San Francisco International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 6h 50m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $250–1,100
Flights from San Francisco International Airport to Mcghee Tyson Airport via Nashville
- Ave. Duration
- 10h 10m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $250–1,100
Flights from Oakland International Airport to Mcghee Tyson Airport via Las Vegas
- Ave. Duration
- 6h 20m
- When
- Saturday
- Estimated price
- $310–1,300
Flights from Oakland International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 7h 17m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $300–1,300
Flights from Oakland International Airport to Mcghee Tyson Airport via Dallas
- Ave. Duration
- 7h 55m
- When
- Monday, Thursday, and Friday
- Estimated price
- $320–1,400
Flights from Norman Y. Mineta San José International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 6h 32m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $300–1,300
Flights from Norman Y. Mineta San José International Airport to Mcghee Tyson Airport via Nashville
- Ave. Duration
- 8h 16m
- When
- Monday to Wednesday
- Estimated price
- $290–1,300
Flights from Norman Y. Mineta San José International Airport to Mcghee Tyson Airport via Dallas
- Ave. Duration
- 8h 20m
- When
- Sunday
- Estimated price
- $310–1,300
Flights from San Francisco International Airport to Nashville
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $120–550
Flights from San Francisco International Airport to Nashville via Denver
- Ave. Duration
- 5h 57m
- When
- Sunday, Tuesday, and Wednesday
- Estimated price
- $120–550
Flights from San Francisco International Airport to Nashville via Dallas
- Ave. Duration
- 6h 25m
- When
- Sunday, Tuesday, and Wednesday
- Estimated price
- $120–550
Flights from Sacramento International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 7h
- When
- Sunday
- Estimated price
- $290–1,300
Flights from Sacramento International Airport to Mcghee Tyson Airport via Dallas
- Ave. Duration
- 9h 5m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $300–1,300
Flights from Sacramento International Airport to Mcghee Tyson Airport via Nashville
- Ave. Duration
- 9h 45m
- When
- Tuesday, Wednesday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $290–1,300
- Website
- delta.com
Flights from San Francisco International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 7h 4m
- When
- Every day
- Estimated price
- $270–1,200
Flights from San Francisco International Airport to Mcghee Tyson Airport via Minneapolis
- Ave. Duration
- 7h 40m
- When
- Every day
- Estimated price
- $280–1,200
Flights from Norman Y. Mineta San José International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 7h 36m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $310–1,400
Flights from Sacramento International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 7h 26m
- When
- Monday, Thursday, Friday, Sunday, and Saturday
- Estimated price
- $310–1,300
- Website
- aa.com
Flights from Sonoma County Airport to Mcghee Tyson Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 35m
- When
- Every day
- Estimated price
- $270–1,200
Flights from San Francisco International Airport to Mcghee Tyson Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 27m
- When
- Every day
- Estimated price
- $260–1,200
Flights from Norman Y. Mineta San José International Airport to Mcghee Tyson Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 9m
- When
- Every day
- Estimated price
- $310–1,300
Flights from San Francisco International Airport to Nashville via Dallas/Ft.Worth
- Ave. Duration
- 6h 50m
- When
- Every day
- Estimated price
- $120–550
Flights from Sacramento International Airport to Mcghee Tyson Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 27m
- When
- Every day
- Estimated price
- $300–1,300
- Website
- united.com
Flights from Sonoma County Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 6h 34m
- When
- Saturday
- Estimated price
- $250–1,100
Flights from San Francisco International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 6h 36m
- When
- Every day
- Estimated price
- $250–1,100
Flights from Norman Y. Mineta San José International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 8h 29m
- When
- Thursday and Sunday
- Estimated price
- $300–1,300
Flights from San Francisco International Airport to Nashville
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $120–550
Flights from San Francisco International Airport to Nashville via Denver
- Ave. Duration
- 6h 30m
- When
- Every day
- Estimated price
- $120–550
Flights from Sacramento International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 8h 6m
- When
- Every day
- Estimated price
- $290–1,300
- Website
- allegiantair.com
Flights from Sonoma County Airport to Mcghee Tyson Airport via Las Vegas
- Ave. Duration
- 9h 31m
- When
- Sunday
- Estimated price
- $260–1,100
Flights from Oakland International Airport to Mcghee Tyson Airport via Phoenix
- Ave. Duration
- 6h 18m
- When
- Friday and Sunday
- Estimated price
- $320–1,400
Flights from Oakland International Airport to Mcghee Tyson Airport via Las Vegas
- Ave. Duration
- 6h 43m
- When
- Monday and Friday
- Estimated price
- $310–1,300
- Website
- flyfrontier.com
Flights from San Francisco International Airport to Nashville via Denver
- Ave. Duration
- 6h 19m
- When
- Monday
- Estimated price
- $210–250
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Martinez to Chicago Union Station
- Ave. Duration
- 2d 3h
- Frequency
- Once daily
- Estimated price
- $1,300–2,100
- Website
- Amtrak
Train from Chicago Union Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 20h 12m
- Frequency
- Once daily
- Estimated price
- $500–850
- Website
- Amtrak
Train from Richmond to Sacramento
- Ave. Duration
- 1h 39m
- Frequency
- Hourly
- Estimated price
- $40–70
- Website
- Amtrak
Train from Martinez to Chicago Union Station
- Ave. Duration
- 2d 3h
- Frequency
- Once daily
- Estimated price
- $1,300–2,100
- Website
- Amtrak
Train from SMART Santa Rosa Downtown to SMART Larkspur
- Ave. Duration
- 1h 9m
- Frequency
- Hourly
- Estimated price
- $1–7
- Website
- Sonoma Marin SMART
Train from SMART Santa Rosa Downtown to SMART San Rafael
- Ave. Duration
- 1h 2m
- Frequency
- Hourly
- Estimated price
- $1–7
- Website
- Sonoma Marin SMART
Train from SMART Santa Rosa Downtown to SMART San Rafael
- Ave. Duration
- 1h 2m
- Frequency
- Hourly
- Estimated price
- $1–7
- Website
- Sonoma Marin SMART
Train from SMART Santa Rosa Downtown to SMART Larkspur
- Ave. Duration
- 1h 9m
- Frequency
- Hourly
- Estimated price
- $1–7
- Website
- Sonoma Marin SMART
Train from SMART Santa Rosa Downtown to SMART San Rafael
- Ave. Duration
- 1h 2m
- Frequency
- Hourly
- Estimated price
- $1–7
- Website
- Sonoma Marin SMART
- Phone
- +1-510-464-6000
- Website
- BART
Subway from El Cerrito Del Norte to Milpitas
- Ave. Duration
- 1h 13m
- Frequency
- Every 30 minutes
- Estimated price
- $8–12
- Website
- BART
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Santa Rosa Amtrak Bus Stop to Martinez
- Ave. Duration
- 1h 45m
- Frequency
- 4 times a day
- Website
- Amtrak
Bus from Santa Rosa Amtrak Bus Stop to Martinez
- Ave. Duration
- 1h 45m
- Frequency
- 4 times a day
- Website
- Amtrak
- Phone
- +1 646-630-7186
- help@wandacoach.com
- Website
- Wanda Coach
Bus from New York to Knoxville
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- $95–140
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $95–140
Bus from New York to Knoxville
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- $95–140
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $95–140
Bus from New York to Knoxville
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- $95–140
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $95–140
- Phone
- +52 664 299 0487
- servicios@acnautobuses.com
- Website
- acnautobuses.com
Bus from Santa Rosa to Phoenix Bus Station
- Ave. Duration
- 21h 10m
- Frequency
- Once daily
- Estimated price
- $60–90
- Schedules at
- acnautobuses.com
- Book at
- acnautobuses.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Phoenix Bus Station to St Louis Bus Station
- Ave. Duration
- 30h 25m
- Frequency
- Twice daily
- Estimated price
- $240–390
- Website
- Greyhound
Bus from St Louis Bus Station to Port Authority Bus Terminal
- Ave. Duration
- 24h 45m
- Frequency
- 3 times a day
- Estimated price
- $170–270
- Website
- Greyhound
- Phone
- +1 415-461-4222
- Website
- Marin Airporter
Bus from Larkspur - pickup to San Francisco Airport
- Ave. Duration
- 1h 3m
- Frequency
- Hourly
- Estimated price
- $32
- Website
- Marin Airporter
- Adult One-way
- $32
Bus from Larkspur - pickup to San Francisco Airport
- Ave. Duration
- 1h 3m
- Frequency
- Hourly
- Estimated price
- $32
- Website
- Marin Airporter
- Adult One-way
- $32
- Phone
- +1 707-837-8700
- Website
- Groome Transportation
Bus from San Rafael to Oakland International Airport
- Ave. Duration
- 1h
- Frequency
- Every 3 hours
- Estimated price
- $25–55
- Website
- Groome Transportation
- First Passenger
- $25–55
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Chicago Bus Station to New York Midtown
- Ave. Duration
- 20h 10m
- Frequency
- Twice daily
- Estimated price
- $140–230
- Schedules at
- Flixbus USA
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Booking & Getting There
Yes, the driving distance between Santa Rosa to Knoxville is 2523 miles. It takes approximately 40h 9m to drive from Santa Rosa to Knoxville.
There are 325+ hotels available in Knoxville.




















