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There are 5 ways to get from Indianapolis to Knoxville by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus via University of Cincinnati  •  8 h 16 min

  1. Take the bus from Indianapolis, IN to University of Cincinnati
  2. Take the bus from Cincinnati, Oh to Knoxville, Tn 1109 / ...

$42 - $95

4 alternative options

Bus  •  9 h

  1. Take the bus from Indianapolis, IN to Cincinnati, OH Detroit
  2. Take the bus from Cincinnati, Oh to Knoxville, Tn 1109 / ...

$47 - $101

Bus via Louisville, KY  •  10 h

  1. Take the bus from Indianapolis, IN to Louisville, KY
  2. Take the bus from Louisville, KY to Lexington, KY
  3. Take the bus from Lexington, Ky to Knoxville, Tn

$77 - $126

Drive  •  5 h 52 min

  1. Drive from Indianapolis to Knoxville 360.4 miles

$35 - $55

Fly  •  5 h 13 min

  1. Fly from Indianapolis (IND) to Knoxville (TYS) IND - TYS

$257 - $1,172

Questions & Answers

The cheapest way to get from Indianapolis to Knoxville is to drive which costs $35 - $55 and takes 5 h 52 min.

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The quickest way to get from Indianapolis to Knoxville is to fly which costs $250 - $1,200 and takes 5 h 13 min.

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No, there is no direct bus from Indianapolis to Knoxville. However, there are services departing from Indianapolis, IN and arriving at Knoxville, Tn via Jefferson Ave & University Ave and Cincinnati, Oh. The journey, including transfers, takes approximately 8 h 16 min.

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The distance between Indianapolis and Knoxville is 292 miles. The road distance is 360.4 miles.

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The best way to get from Indianapolis to Knoxville without a car is to bus which takes 8 h 16 min and costs $40 - $95.

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It takes approximately 8 h 16 min to get from Indianapolis to Knoxville, including transfers.

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Indianapolis to Knoxville bus services, operated by Megabus, depart from Indianapolis, IN station.

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The best way to get from Indianapolis to Knoxville is to bus which takes 8 h 16 min and costs $40 - $95. Alternatively, you can fly, which costs $250 - $1,200 and takes 5 h 13 min.

Mode details

There is no direct flight from Indianapolis Airport to Knoxville Airport. The quickest flight takes 3 h 16 min and has one stopover.

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Indianapolis to Knoxville bus services, operated by Greyhound USA, arrive at Knoxville, Tn station.

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Map of how to get from Indianapolis to Knoxville.
Launch map view
  • Distance: 291.7 miles
  • Duration: 8 h 16 min

What companies run services between Indianapolis, IN, USA and Knoxville, TN, USA?

You can take a bus from Indianapolis to Knoxville via University of Cincinnati, Jefferson Ave & University Ave, Government Square Area D, and Cincinnati, Oh in around 8 h 16 min. Alternatively, Delta, United Airlines and American Airlines fly from Indianapolis to Knoxville hourly.

Airlines
Delta
Website
delta.com
Flights from Indianapolis to Knoxville via Atlanta
Ave. Duration
3 h 42 min
When
Every day
Estimated price
$200 - $1,100
Flights from Indianapolis to Knoxville via Detroit
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$210 - $1,100
United Airlines
Website
united.com
Flights from Indianapolis to Knoxville via Chicago O'Hare
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$230 - $1,100
Flights from Indianapolis to Knoxville via Washington Dulles
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$250 - $1,200
American Airlines
Website
aa.com
Flights from Indianapolis to Knoxville via Charlotte
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$210 - $1,100
Flights from Indianapolis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 9 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Indianapolis to Knoxville via Reagan Washington
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$240 - $1,100
Bus operators
Megabus
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Cincinnati, Oh to Knoxville, Tn
Ave. Duration
4 h 25 min
Frequency
5 times a day
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Lexington, Ky to Knoxville, Tn
Ave. Duration
2 h 50 min
Frequency
4 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Indianapolis, IN to Louisville, KY
Ave. Duration
3 h 30 min
Frequency
Once daily
Estimated price
$30 - $45
Book at
hoosierride.com
Bus from Louisville, KY to Lexington, KY
Ave. Duration
1 h 40 min
Frequency
Twice daily
Estimated price
$21 - $28
Book at
hoosierride.com

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More Questions & Answers

Yes, the driving distance between Indianapolis to Knoxville is 360 miles. It takes approximately 5 h 52 min to drive from Indianapolis to Knoxville.

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American Airlines, United Airlines and Delta offer flights from Indianapolis Airport to Knoxville Airport.

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There are 101+ hotels available in Knoxville. Prices start at $55 USD per night.

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The best way to get from Indianapolis to Indianapolis Airport is to line 8 bus which takes 39 min and costs $2.

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