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How to get fromPrague to Sienaby plane, train, train (Trenitalia), bus, night train, or car

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There are 8 ways to get from Prague to Siena by plane, train, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Peretola Airport, train

    best
    1. Fly from Václav Havel Airport Prague (PRG) to Florence Peretola Airport (FLR)plane plane PRG - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    6h 20m
    €90–292

  2. Fly to Pisa International Airport, train

    cheapest
    1. Fly from Václav Havel Airport Prague (PRG) to Pisa International Airport (PSA)plane plane PRG - PSA
    2. Take the train from Pisa Centrale to Empolitrain train
    3. Take the train from Empoli to Sienatrain train
    6h 23m
    €79–270

  3. Train

    1. Take the train from Praha Hlavni Nadrazi to Wien Hbftrain train Rj
    2. Take the train from Wien Hbf to Venezia Mestretrain train Rjx
    3. Take the train from Venezia Mestre to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    16h 32m
    €150–269

  4. Bus

    1. Take the bus from Praha, ÚAN Florenc to Florence Villa Constanza Bus Stationbus bus N538 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    17h
    €96–142

  5. Train, night train

    1. Take the train from Praha Hlavni Nadrazi to Muenchen Hbftrain train Ec
    2. Take the nighttrain from Muenchen Hbf to Bologna Centralenighttrain night train Nj
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    19h 2m
    €159–270

  6. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Václav Havel Airport Prague (PRG) to Bologna Guglielmo Marconi Airport (BLQ)plane plane PRG - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 50m
    €82–262

  7. Bus via Florence

    1. Take the bus from Prague Florenc Central Bus Station to Florence Villa Constanza Bus Stationbus bus : Prague Central Bus Station - Rome Tiburtina Bus Station / ...
    2. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131R / ...
    18h 32m
    €79–123

  8. Drive  1,020.8 km

    1. Drive from Prague to Sienacar car 1,020.8 km
    11h 1m
    €165–238

Prague to Siena by train

Calendar14Weekly Trains
Duration16h 32mAverage Duration
Ticket€150Cheapest Price
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Comparing Your Travel Options

Map of how to get from Prague to Siena.ExpandLaunch map view
  • Distance: 850.7 km
  • Duration: 6h 20m

What companies run services between Prague, Czechia and Siena, Italy?

You can take a train from Praha Hlavni Nadrazi to Siena via Wien Hbf, Venezia Mestre, and Firenze S.M.N. in around 16h 32m. Alternatively, you can take a bus from Praha, ÚAN Florenc to Siena via Florence Villa Constanza Bus Station in around 17h.

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