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How to get fromSantander to Sienaby plane, train, bus, train (Renfe) or car

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There are 9 ways to get from Santander to Siena by plane, train, bus, train (Renfe), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Peretola Airport, train

    best
    1. Fly from Santander Airport (SDR) to Florence Peretola Airport (FLR)planeSDR - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain
    7h 30m
    €86–229
  2. Train, bus

    1. Take the train from Santander to Madrid ChamartíntrainAlv / ...
    2. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Perpignantrain
    3. Take the bus from Perpignan to Florencebus
    4. Take the bus from Florence Villa Constanza Bus Station to Sienabus443 / ...
    24h 34m
    €173–293
  3. Train

    1. Take the train from Santander to Madrid ChamartíntrainAlv / ...
    2. Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Marseille St Charlestrain
    3. Take the train from Marseille St Charles to Roma Terminitrain
    4. Take the train from Roma Termini to Florence Santa Maria Novellatrain
    5. Take the train from Firenze S.M.N. to SienatrainRe
    35h 9m
    €285–562
  4. Drive 1,538.7 km

    1. Drive from Santander to Sienacar1,538.7 km
    15h 25m
    €243–351
  5. Fly to Pisa International Airport, train

    1. Fly from Santander Airport (SDR) to Pisa International Airport (PSA)planeSDR - PSA
    2. Take the train from Pisa Centrale to Empolitrain
    3. Take the train from Empoli to Sienatrain
    8h 39m
    €148–213
  6. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Santander Airport (SDR) to Bologna Guglielmo Marconi Airport (BLQ)planeSDR - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train
    3. Take the train from Firenze S.M.N. to Sienatrain
    5h 34m
    €94–293
  7. Bus

    1. Take the bus from Santander to Bordeauxbus
    2. Take the bus from Bordeaux to Florence Villa Constanza Bus Stationbus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus443 / ...
    25h 49m
    €90–233
  8. Bus, train via Turin

    1. Take the bus from Santander E.A. to Estación de Autobuses Donostia-San Sebastiánbus
    2. Take the bus from San Sebastian Central Bus Station to Turin Corso Vittorio Emanuele IIbus
    3. Take the train from Torino Porta Susa to Florence Santa Maria Novellatrain
    4. Take the bus from Firenze Autostazione to Siena-Via Tozzibus131
    28h 35m
  9. Bus, train

    1. Take the bus from Santander to Padovabus
    2. Take the train from Padova to Firenze S.M.N.trainFr
    3. Take the bus from Firenze Autostazione to Siena-Via Tozzibus131
    29h 31m

Santander to Siena by train and bus

Calendar7Weekly Services
Duration24h 34mAverage Duration
Ticket€173Cheapest Price
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Questions & Answers

What companies run services between Santander, Spain and Siena, Italy?

You can take a train from Santander to Siena via Madrid Chamartín, Madrid-Atocha Cercanías, Madrid-Puerta de Atocha-Almudena Grandes, Marseille St Charles, Roma Termini, and Firenze S.M.N. in around 35h 9m. Alternatively, you can take a bus from Santander to Siena via Bordeaux and Florence Villa Constanza Bus Station in around 25h 49m.

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