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How to get fromInterlaken to Sienaby train (Trenitalia), bus, car, train or plane

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There are 7 ways to get from Interlaken to Siena by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Spiez to Domodossolatrain train Ec / ...
    2. Take the train from Domodossola to Rho Fiera Milanotrain train
    3. Take the train from Milano Rogoredo to Bologna centraletrain train
    4. Take the train from Bologna Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    9h 4m
    €72–217
  2. Bus

    cheapest
    1. Take the bus from Interlaken Sonnenhof to Zürich HB Schweizerhofbus bus
    2. Take the bus from Zurich Bus Station to Milanbus bus
    3. Take the bus from Milano, Autostazione Lampugnano to Sienabus bus 500 / ...
    12h 32m
    €65–98
  3. Drive 621.9 km

    1. Drive from Interlaken to Sienacar car 621.9 km
    6h 45m
    €110–159
  4. Train, fly to Florence Peretola Airport

    1. Take the train from Interlaken West to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 3m
    €161–369
  5. Train, bus

    1. Take the train from Spiez to Domodossolatrain train Ec / ...
    2. Take the train from Domodossola to Milano Centraletrain train
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    9h 6m
    €65–162
  6. Train, bus via Rho

    1. Take the train from Spiez to Domodossolatrain train Ec / ...
    2. Take the train from Domodossola to Rho Fiera Milanotrain train
    3. Take the train from Rho Fiera to Florence Santa Maria Novellatrain train
    4. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    9h 10m
    €84–143
  7. Train, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Interlaken West to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Bologna Guglielmo Marconi Airport (BLQ)plane plane ZRH - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    8h 44m
    €150–427

Interlaken to Siena by train

Calendar99Weekly Trains
Duration9h 4mAverage Duration
Ticket€72Cheapest Price
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Questions & Answers

What companies run services between Interlaken, Switzerland and Siena, Italy?

You can take a train from Interlaken West to Siena via Spiez, Domodossola, Rho Fiera Milano, Milano Rogoredo, Bologna Centrale, and Firenze S.M.N. in around 9h 4m. Alternatively, you can take a bus from Interlaken Sonnenhof to Siena via Zürich HB Schweizerhof, Zurich Bus Station, and Milano, Autostazione Lampugnano in around 12h 32m.

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