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How to get fromPittsburgh to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), car or train

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There are 5 ways to get from Pittsburgh to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)planePIT - STL
    4h 45m

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to St Louis Bus StationbusGreyhound US0421
    12h 55m
    $65–180

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union StationtrainFloridian
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    15h 32m
    $104–412

  4. Drive 598.9 mi

    1. Drive from Pittsburgh to St. Louiscar598.9 mi
    10h
    $110–158

  5. Train to Cleveland-Hopkins International Airport, fly

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)planeCLE - STL
    7h 19m
    $217–531

Pittsburgh to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration12h 55mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

What companies run services between Pittsburgh, PA, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Pittsburgh Intermodal Station to St Louis Bus Station 3 times a day. Tickets cost $65–180 and the journey takes 12h 55m. Alternatively, you can take a train from Pittsburgh Amtrak Station to St. Louis via Chicago Union Station in around 15h 32m.

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