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How to get fromOhio to St. Louisby plane, bus (Greyhound), car, or bus

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There are 8 ways to get from Ohio to St. Louis by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Glenn Columbus International Airport

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    3h 55m
    $805–906

  2. Bus

    cheapest
    1. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    9h 5m
    $65–130

  3. Bus via Indianapolis

    1. Take the bus from Columbus to Indianapolisbus bus FlixBus 2511 / ...
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    8h 39m

  4. Drive 416.3 mi

    1. Drive from Columbus to St. Louiscar car 416.3 mi
    7h
    $76–110

  5. Fly from Cleveland-Hopkins International Airport

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3h 45m
    $496–906

  6. Fly from Covington

    1. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    6h 4m
    $127–707

  7. Fly from Dayton

    1. Fly from Dayton (DAY) to Lambert–St. Louis International Airport (STL)plane plane DAY - STL
    6h 22m
    $125–705

  8. Bus to Detroit, fly

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    5h 29m
    $486–998

John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL) flights

Calendar32Weekly Planes
Duration2h 42mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Ohio to St. Louis.ExpandLaunch map view
  • Distance: 435.3 mi
  • Duration: 3h 55m

What companies run services between Ohio, USA and St. Louis, MO, USA?

Southwest Airlines and Delta fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL) 5 times a day. Alternatively, you can take a bus from Columbus to St Louis Bus Station via Indianapolis and Indianapolis Union Station in around 8h 39m.

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