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How to get fromOhio to St. Louisby plane, bus (Greyhound), car, or bus

Find Transport to St. Louis

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There are 7 ways to get from Ohio to St. Louis by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Glenn Columbus International Airport

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    4h 5m
    $105–656

  2. Drive  416.3 mi

    cheapest
    1. Drive from Columbus to St. Louiscar car 416.3 mi
    7h
    $74–107

  3. Bus (Greyhound)

    1. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    9h 25m
    $75–120

  4. Fly from Cleveland-Hopkins International Airport

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3h 55m
    $106–656

  5. Fly from Covington

    1. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    6h 29m
    $147–857

  6. Bus to Detroit, fly

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    5h 34m

  7. Bus to Pittsburgh International Airport, fly

    1. Take the bus from Youngstown Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    6h 18m
    $125–671

Ohio to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration9h 25mAverage Duration
Ticket$75Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Ohio to St. Louis.ExpandLaunch map view
  • Distance: 435.3 mi
  • Duration: 4h 5m

What companies run services between Ohio, USA and St. Louis, MO, USA?

Southwest Airlines and Delta fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, Greyhound USA operates a bus from Columbus to St Louis Bus Station 3 times a day. Tickets cost $75–120 and the journey takes 9h 25m.

Airlines
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