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How to get fromGainesville to St. Louisby plane, bus (Flixbus), car, bus or bus (Greyhound, Flixbus)

Find Transport to St. Louis

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There are 7 ways to get from Gainesville to St. Louis by plane, bus (Flixbus), car, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Gainesville Regional Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Lambert–St. Louis International Airport (STL)plane plane GNV - STL
    7h 23m
    $114–654

  2. Bus

    cheapest
    1. Take the bus from Gainesville to Atlanta - Civic Center MARTA Stationbus bus Orlando
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    17h 9m
    $90–319

  3. Drive 881.6 mi

    1. Drive from Gainesville to St. Louiscar car 881.6 mi
    14h 39m
    $161–233

  4. Bus to Jacksonville, fly

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL)plane plane JAX - STL
    7h 1m
    $171–878

  5. Bus to Orlando, fly

    1. Take the bus from Gainesville to Orlando RedCoach Stationbus bus
    2. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    6h 53m
    $238–518

  6. Bus via Gainesville (Flixbus)

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus FlixBus N2415 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    17h 45m
    $106–252

  7. Bus via Gainesville Bus Stop

    1. Take the bus from Gainesville Bus Stop to Atlanta Bus Stationbus bus Greyhound US0630
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    20h 29m
    $106–302

Gainesville to St. Louis by bus and subway

Calendar7Weekly Services
Duration17h 9mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

What companies run services between Gainesville, FL, USA and St. Louis, MO, USA?

American Airlines and Delta fly from Gainesville Regional Airport (GNV) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Gainesville to St Louis Bus Station via Atlanta - Civic Center MARTA Station, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 17h 9m.

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