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How to get fromCleveland to St. Louisby plane, train (Amtrak), bus (Greyhound), car or bus (Flixbus)

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There are 5 ways to get from Cleveland to St. Louis by plane, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)planeCLE - STL
    3h 50m
    $176–476

  2. Bus

    cheapest
    1. Take the bus from Cleveland to CambridgebusRoute C SB
    2. Take the bus from Cambridge, OH to St Louis Bus StationbusGreyhound US0421
    14h 20m
    $67–166

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union StationtrainFloridian / ...
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    12h 32m
    $92–398

  4. Drive 552.8 mi

    1. Drive from Cleveland to St. Louiscar552.8 mi
    9h 14m
    $101–146

  5. Bus via Chicago

    1. Take the bus from Cleveland to Shipshewanabus
    2. Take the bus from Shipshewana to Chicagobus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus
    15h 45m
    $71–206

Cleveland to St. Louis by train (Amtrak)

Calendar21Weekly Trains
Duration12h 32mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

What companies run services between Cleveland, OH, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a train from Cleveland Amtrak to St. Louis via Chicago Union Station in around 12h 32m.

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