There are 5 ways to get from Cleveland to St. Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  3 h 38 min

  1. Fly from Cleveland (CLE) to St. Louis (STL) CLE - STL

$106 - $316

Cheapest option

Megabus, bus  •  13 h 40 min

  1. Take the Megabus from Cleveland to Chicago, IL
  2. Take the bus from Chicago, IL to St. Louis via St Louis

$59 - $86

3 alternative options

Bus  •  12 h 27 min

  1. Take the bus from Cleveland, OH to Columbus, OH Schedule 21:Cleveland-Chicago
  2. Take the bus from Columbus, Oh to St Louis, Mo 1683 / ...

$60 - $143

Train  •  13 h 16 min

  1. Take the train from Cleveland Amtrak to Chicago Union Station Capitol Limited / ...
  2. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$108 - $279

Drive  •  9 h 22 min

  1. Drive from Cleveland to St. Louis 560.4 miles

$55 - $80

Questions & Answers

The cheapest way to get from Cleveland to St. Louis is to drive which costs $55 - $80 and takes 9 h 22 min.

More details

The quickest way to get from Cleveland to St. Louis is to fly which costs $100 - $320 and takes 3 h 38 min.

More details

No, there is no direct bus from Cleveland to St. Louis. However, there are services departing from Cleveland, OH and arriving at St Louis, Mo via Columbus, Oh. The journey, including transfers, takes approximately 12 h 27 min.

More details

No, there is no direct train from Cleveland to St. Louis station. However, there are services departing from Cleveland Amtrak and arriving at St. Louis Gateway Station via Chicago Union Station. The journey, including transfers, takes approximately 13 h 16 min.

More details

The distance between Cleveland and St. Louis is 494 miles. The road distance is 560.4 miles.

Get driving directions

The best way to get from Cleveland to St. Louis without a car is to bus which takes 12 h 27 min and costs $55 - $150.

More details

It takes approximately 3 h 38 min to get from Cleveland to St. Louis, including transfers.

More details

Cleveland to St. Louis bus services, operated by Barons Bus, depart from Cleveland, OH station.

More details

Cleveland to St. Louis train services, operated by Amtrak, depart from Cleveland Amtrak station.

More details

The best way to get from Cleveland to St. Louis is to fly which takes 3 h 38 min and costs $100 - $320. Alternatively, you can bus, which costs $55 - $150 and takes 12 h 27 min, you could also train, which costs $100 - $280 and takes 13 h 16 min.

Mode details

The quickest flight from Cleveland Airport to St. Louis Airport is the direct flight which takes 1 h 30 min.

Search flights

Cleveland to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

More details

Map of how to get from Cleveland to St. Louis.
Launch map view
  • Distance: 494 miles
  • Duration: 3 h 38 min

What companies run services between Cleveland, OH, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines and United Airlines fly from Cleveland to St. Louis every 4 hours. Alternatively, you can take a bus from Cleveland to St. Louis via Columbus, OH and Columbus, Oh in around 12 h 27 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Cleveland to St. Louis
Ave. Duration
1 h 32 min
When
Every day
Estimated price
$210 - $550
Flights from Cleveland to St. Louis via Chicago Midway
Ave. Duration
3 h 35 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $550
Flights from Cleveland to St. Louis via Nashville
Ave. Duration
3 h 47 min
When
Sunday
Estimated price
$210 - $550
Flights from Cleveland to St. Louis via Milwaukee
Ave. Duration
3 h 55 min
When
Sunday
Estimated price
$210 - $550
American Airlines
Website
aa.com
Flights from Cleveland to St. Louis via Chicago O'Hare
Ave. Duration
3 h 41 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$120 - $550
United Airlines
Website
united.com
Flights from Cleveland to St. Louis via Chicago O'Hare
Ave. Duration
3 h 57 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$100 - $650
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Cleveland Amtrak to Chicago Union Station
Ave. Duration
6 h 46 min
Frequency
3 times a day
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$100 - $150
Business Coach Seat
$100 - $150
Room
$260 - $360
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5 h 30 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to St Louis, Mo
Ave. Duration
9 h 10 min
Frequency
Hourly
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Cleveland to Chicago, IL
Ave. Duration
6 h 40 min
Frequency
Twice daily
Estimated price
$30 - $50
Book at
megabus.com
Bus from Chicago, IL to St. Louis
Ave. Duration
6 h
Frequency
Twice daily
Estimated price
$29 - $40
Book at
megabus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.