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How to get fromCleveland to St. Louisby plane, train (Amtrak), bus (Greyhound), car or bus (Flixbus)

Find Transport to St. Louis

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There are 5 ways to get from Cleveland to St. Louis by plane, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    4h 5m
    $176–456

  2. Bus

    cheapest
    1. Take the bus from Cleveland to Cambridgebus bus Route C SB
    2. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus Greyhound US0421
    14h 20m
    $67–166

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    12h 32m
    $80–337

  4. Drive 553 mi

    1. Drive from Cleveland to St. Louiscar car 553 mi
    9h 19m
    $101–146

  5. Bus via Chicago

    1. Take the bus from Cleveland to Shipshewanabus bus
    2. Take the bus from Shipshewana to Chicagobus bus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    15h 45m
    $71–181

Cleveland to St. Louis by train (Amtrak)

Calendar21Weekly Trains
Duration12h 32mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

What companies run services between Cleveland, OH, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a train from Cleveland Amtrak to St. Louis via Chicago Union Station in around 12h 32m.

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