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How to get fromCleveland to St. Louisby plane, bus (Greyhound), train (Amtrak), or car

Find Transport to St. Louis

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There are 5 ways to get from Cleveland to St. Louis by plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3h 45m
    $496–906

  2. Bus via Indianapolis

    cheapest
    1. Take the bus from Cleveland to Toledobus bus
    2. Take the bus from Toledo to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    11h 45m
    $67–180

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    12h 32m
    $193–413

  4. Drive 553 mi

    1. Drive from Cleveland to St. Louiscar car 553 mi
    9h 23m
    $101–146

  5. Bus

    1. Take the bus from Cleveland Ohio Greyhound Station to Columbus, Ohio Greyhound Stationbus bus 379 D
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    15h 43m
    $122–201

Cleveland to St. Louis by bus

Calendar7Weekly Buses
Duration11h 45mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to St. Louis.ExpandLaunch map view
  • Distance: 512.3 mi
  • Duration: 3h 45m

What companies run services between Cleveland, OH, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Cleveland to St Louis Bus Station via Toledo and Indianapolis Union Station in around 11h 45m.

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