There are 11 ways to get from Como to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Como S. Giovanni to Milano CentraleEc
- Take the train from Milano Centrale to Roma TerminiFr / ...
- Take the train from Roma Termini to IserniaRe
7h 14m€55–142Bus via Bologna
cheapest- Take the bus from Como to Bologna Centrale1524
- Take the bus from Bologna Centrale to Isernia433
14h 4m€36–115Bus
- Take the bus from Como to Roma, Autostazione Tiburtina518 / ...
- Take the bus from Roma, Autostazione Tiburtina to IserniaRome Tiburtina
12h 50m€40–98Drive 770.3 km
- Drive from Como to Isernia770.3 km
7h 16m€120–174Fly Milano Malpensa Airport to Naples Airport, train
- Fly from Milano Malpensa Airport (MXP) to Naples Airport (NAP)MXP - NAP
- Take the train from Napoli Centrale to Isernia
6h 52m€44–181Fly Milan Linate Airport to Naples Airport, train
- Fly from Milan Linate Airport (LIN) to Naples Airport (NAP)LIN - NAP
- Take the train from Napoli Centrale to Isernia
7h 19m€60–259Train, bus to Il Caravaggio International Airport, fly to Naples Airport
- Take the train from Como S. Giovanni to Milano Centrale
- Take the bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Fly from Il Caravaggio International Airport (BGY) to Naples Airport (NAP)BGY - NAP
- Take the train from Napoli Centrale to Isernia
7h 29m€62–230Fly Milano Malpensa Airport to Foggia Gino Lisa Airport, bus
- Fly from Milano Malpensa Airport (MXP) to Foggia Gino Lisa Airport (FOG)MXP - FOG
- Take the bus from Foggia to Isernia
7h 12m€61–222Fly Milan Linate Airport to Fiumicino International Airport, train
- Fly from Milan Linate Airport (LIN) to Fiumicino International Airport (FCO)LIN - FCO
- Take the train from Roma Termini to Isernia
7h 38m€65–293Fly Milan Linate Airport to Foggia Gino Lisa Airport, bus
- Fly from Milan Linate Airport (LIN) to Foggia Gino Lisa Airport (FOG)LIN - FOG
- Take the bus from Foggia to Isernia
7h 38m€151–460Fly Milano Malpensa Airport to Abruzzo Airport, bus
- Fly from Milano Malpensa Airport (MXP) to Abruzzo Airport (PSR)MXP - PSR
- Take the bus from Pescara to Isernia
8h 9m€45–212
Como to Isernia by train
Questions & Answers
The cheapest way to get from Como to Isernia is to bus via Bologna which costs €35 - €120 and takes 14h 4m.
The fastest way to get from Como to Isernia is to fly and train which takes 6h 52m and costs €40 - €190.
No, there is no direct bus from Como to Isernia. However, there are services departing from Como and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 12h 50m.
No, there is no direct train from Como to Isernia. However, there are services departing from Como S. Giovanni and arriving at Isernia via Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 7h 14m.
The distance between Como and Isernia is 795 km. The road distance is 770.3 km.
The best way to get from Como to Isernia without a car is to train which takes 7h 14m and costs €55 - €150.
It takes approximately 7h 14m to get from Como to Isernia, including transfers.
Como to Isernia bus services, operated by FlixBus, depart from Como station.
Como to Isernia train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Como S. Giovanni station.
The best way to get from Como to Isernia is to train which takes 7h 14m and costs €55 - €150. Alternatively, you can bus, which costs €40 - €100 and takes 12h 50m.
What companies run services between Como, Italy and Isernia, Italy?
You can take a train from Como S. Giovanni to Isernia via Milano Centrale and Roma Termini in around 7h 14m. Alternatively, you can take a bus from Como to Isernia via Roma, Autostazione Tiburtina in around 12h 50m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- ryanair.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €35–170
Flights from Il Caravaggio International Airport to Naples Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €40–190
Flights from Il Caravaggio International Airport to Naples Airport via Cagliari
- Ave. Duration
- 3h 40m
- When
- Monday and Sunday
- Estimated price
- €40–190
Flights from Milano Malpensa Airport to Abruzzo Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €29–150
- Website
- ita-airways.com
Flights from Milan Linate Airport to Naples Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €40–170
Flights from Milan Linate Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h
- When
- Monday to Saturday
- Estimated price
- €40–170
Flights from Milan Linate Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €45–170
Flights from Milan Linate Airport to Fiumicino International Airport via Alghero
- Ave. Duration
- 3h 15m
- When
- Monday and Friday
- Estimated price
- €45–170
- Website
- easyjet.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- €26–140
- Website
- aeroitalia.com
Flights from Milano Malpensa Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €30–600
Flights from Milan Linate Airport to Fiumicino International Airport via Olbia
- Ave. Duration
- 3h
- When
- Every day
- Estimated price
- €100–400
- Website
- flexflight.dk
Flights from Milano Malpensa Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €30–600
Flights from Milan Linate Airport to Fiumicino International Airport via Olbia
- Ave. Duration
- 3h
- When
- Every day
- Estimated price
- €100–400
- Website
- bristowgroup.com
Flights from Milan Linate Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €120–200
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Como S. Giovanni to Milano Centrale
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €22–40
- Website
- https://www.sbb.ch/en
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Como S. Giovanni to Milano Centrale
- Ave. Duration
- 44 min
- Frequency
- Hourly
- Estimated price
- €4–6
- Website
- https://www.trenord.it/en/
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €50–110
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 49m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 7h 12m
- Frequency
- Once daily
- Estimated price
- €40–75
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 12m
- Frequency
- Every 4 hours
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- Every 4 hours
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Como to Roma, Autostazione Tiburtina
- Ave. Duration
- 9h 40m
- Frequency
- Twice daily
- Estimated price
- €30–70
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €16–26
- Website
- https://www.flixbus.co.uk
Bus from Como to Bologna Centrale
- Ave. Duration
- 4h 40m
- Frequency
- 6 times a week
- Estimated price
- €18–40
- Website
- https://www.flixbus.co.uk
Bus from Bologna Centrale to Isernia
- Ave. Duration
- 8h 24m
- Frequency
- Once daily
- Estimated price
- €18–80
- Website
- https://www.flixbus.co.uk
Bus from Foggia to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- Once daily
- Estimated price
- €24–40
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Estimated price
- €16–27
- Website
- https://www.flixbus.co.uk
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Como to Roma, Autostazione Tiburtina
- Ave. Duration
- 9h 30m
- Frequency
- Once daily
- Estimated price
- €40–75
- Website
- https://marinobus.it/en/
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- info@flibco.com
- Website
- flibco.com
Bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- €8–10
- Website
- https://www.flibco.com/en
- Phone
- +39 02 3008 9000
- mail@autostradale.it
- Website
- autostradale.it
Bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Ave. Duration
- 1h
- Frequency
- Every 30 minutes
- Estimated price
- €4–17
- Website
- https://autostradale.it/?lang=en-GB
- Standard Rate
- €13–17
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
Getting to Milan from the airport
Read the travel guide
More Questions & Answers
Como to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Como to Isernia train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Milano Centrale station.
Yes, the driving distance between Como to Isernia is 770 km. It takes approximately 7h 16m to drive from Como to Isernia.
Book your Como to Isernia bus tickets online with Omio and FlixBus.
There are 418+ hotels available in Isernia.

















































