There are 11 ways to get from Como to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Como S. Giovanni to Milano Centraletrain S11
- Take the train from Milano Centrale to Roma Terminitrain
- Take the train from Roma Termini to Iserniatrain Re
7h 8m€110–237Fly Milano Malpensa Airport to Abruzzo Airport, bus
cheapest- Fly from Milano Malpensa Airport (MXP) to Abruzzo Airport (PSR)plane MXP - PSR
- Take the bus from Pescara to Iserniabus
8h 14m€41–160Bus
- Take the bus from Como Grandate to Caianellobus
- Take the bus from Casello - A1 Ingresso Caianello to Iserniabus 6
12h 8m€63–88Drive 770.4 km
- Drive from Como to Iserniacar 770.4 km
7h 20m€120–174Fly Milano Malpensa Airport to Naples Airport, train
- Fly from Milano Malpensa Airport (MXP) to Naples Airport (NAP)plane MXP - NAP
- Take the train from Caserta to Iserniatrain
7h 20m€45–162Train via Como S. Giovanni
- Take the train from Como S. Giovanni to Milano Centraletrain S11
- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Iserniatrain Re
7h 20m€110–247Bus via Rome
- Take the bus from Como to Roma, Autostazione Tiburtinabus 518
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
12h 50m€50–92Fly Milan Linate Airport to Fiumicino International Airport, train
- Fly from Milan Linate Airport (LIN) to Fiumicino International Airport (FCO)plane LIN - FCO
- Take the train from Roma Termini to Iserniatrain
7h 33m€78–195Fly Milan Linate Airport to Naples Airport, train
- Fly from Milan Linate Airport (LIN) to Naples Airport (NAP)plane LIN - NAP
- Take the train from Caserta to Iserniatrain
7h 41m€58–162Train to Il Caravaggio International Airport, fly to Naples Airport, train
- Take the train from Como S. Giovanni to Milano Centraletrain
- Fly from Il Caravaggio International Airport (BGY) to Naples Airport (NAP)plane BGY - NAP
- Take the train from Caserta to Iserniatrain
7h 52m€74–276Fly Milan Linate Airport to Foggia Gino Lisa Airport, bus
- Fly from Milan Linate Airport (LIN) to Foggia Gino Lisa Airport (FOG)plane LIN - FOG
- Take the bus from Foggia to Iserniabus
7h 48m€81–247
Como to Isernia by bus and foot
Questions & Answers
The cheapest way to get from Como to Isernia is to bus via Rome which costs €50 - €95 and takes 12h 50m.
The fastest way to get from Como to Isernia is to train which takes 7h 8m and costs €110 - €240.
No, there is no direct bus from Como to Isernia. However, there are services departing from Como Grandate and arriving at Isernia via Casello - A1 Ingresso Caianello. The journey, including transfers, takes approximately 12h 8m.
No, there is no direct train from Como to Isernia. However, there are services departing from Como S. Giovanni and arriving at Isernia via Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 7h 8m.
The distance between Como and Isernia is 813 km. The road distance is 770.4 km.
The best way to get from Como to Isernia without a car is to train which takes 7h 8m and costs €110 - €240.
It takes approximately 7h 8m to get from Como to Isernia, including transfers.
Como to Isernia bus services, operated by FlixBus, depart from Como station.
Como to Isernia train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Como S. Giovanni station.
The best way to get from Como to Isernia is to train which takes 7h 8m and costs €110 - €240. Alternatively, you can bus, which costs €60 - €90 and takes 12h 8m.
What companies run services between Como, Italy and Isernia, Italy?
You can take a train from Como S. Giovanni to Isernia via Milano Centrale and Roma Termini in around 7h 8m. Alternatively, you can take a bus from Como Grandate to Isernia via Caianello and Casello - A1 Ingresso Caianello in around 12h 8m.
- Website
- ita-airways.com
Flights from Milan Linate Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €45–130
Flights from Milan Linate Airport to Naples Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €40–130
Flights from Milan Linate Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h 21m
- When
- Every day
- Estimated price
- €40–130
- Website
- ryanair.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €30–130
Flights from Il Caravaggio International Airport to Naples Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €40–160
Flights from Il Caravaggio International Airport to Naples Airport via Cagliari
- Ave. Duration
- 3h 45m
- When
- Friday
- Estimated price
- €40–160
Flights from Milano Malpensa Airport to Abruzzo Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €25–130
- Website
- easyjet.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- €25–130
- Website
- aeroitalia.com
Flights from Milan Linate Airport to Fiumicino International Airport via Olbia
- Ave. Duration
- 3h 3m
- When
- Every day
- Estimated price
- €55–190
Flights from Milan Linate Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €65–390
- Website
- flexflight.dk
Flights from Milan Linate Airport to Fiumicino International Airport via Olbia
- Ave. Duration
- 3h 3m
- When
- Every day
- Estimated price
- €55–190
Flights from Milan Linate Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €65–390
- Website
- flyulendo.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €35–160
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Como S. Giovanni to Milano Centrale
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €16–50
- Website
- https://www.sbb.ch/en
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 5m
- Frequency
- Every 30 minutes
- Estimated price
- €70–150
- Website
- https://www.italotreno.it/en
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €23–40
- Website
- https://www.trenitalia.com/en.html
Train from Caserta to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- 5 times a day
- Estimated price
- €11–20
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Hourly
- Estimated price
- €80–160
- Schedules at
- trenitalia.com
- Phone
- +39 0827 34 117
- info@gruppodimaio.it
- Website
- gruppodimaio.it
Bus from Como Grandate to Caianello
- Ave. Duration
- 10h
- Frequency
- Twice a week
- Estimated price
- €60–85
- Schedules at
- gruppodimaio.it
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Casello - A1 Ingresso Caianello to Isernia
- Ave. Duration
- 55 min
- Frequency
- 3 times a day
- Estimated price
- €2–3
- Schedules at
- satiautobus.com
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Como to Roma, Autostazione Tiburtina
- Ave. Duration
- 9h 40m
- Frequency
- Once daily
- Estimated price
- €40–75
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €11–20
- Website
- https://www.flixbus.co.uk
Bus from Foggia to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- Once daily
- Estimated price
- €9–16
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Estimated price
- €11–20
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
Getting to Milan from the airport
Read the travel guide
More Questions & Answers
Como to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Como to Isernia train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Milano Centrale station.
Yes, the driving distance between Como to Isernia is 770 km. It takes approximately 7h 20m to drive from Como to Isernia.
Book your Como to Isernia train tickets online with Omio.
Book your Como to Isernia bus tickets online with Omio and FlixBus.
There are 439+ hotels available in Isernia.




























