There are 12 ways to get from America to Isernia by train, plane, train (Trenitalia), bus, night train, car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Düsseldorf International Airport, fly to Fiumicino International Airport, train
best- Take the train from Venlo to Duesseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Fiumicino International Airport (FCO)plane DUS - FCO
- Take the train from Roma Termini to Iserniatrain
9h 46m€129–313Fly Weeze Airport to Abruzzo Airport, bus
cheapest- Fly from Weeze Airport (NRN) to Abruzzo Airport (PSR)plane NRN - PSR
- Take the bus from Pescara Airport to San Salvo Marinabus
- Take the bus from San Salvo Marina to Iserniabus
7h 14m€68–330Train
- Take the train from Venlo to Frankfurt(Main)Hbftrain Ice
- Take the train from Frankfurt to Chiassotrain Ec
- Take the train from Chiasso to Milano Centraletrain S11
- Take the train from Milano Centrale to Roma Terminitrain
- Take the train from Roma Termini to Iserniatrain Re
19h 34m€360–557Bus
- Take the bus from Venlo Station to Düsseldorf Airportbus
- Take the bus from Duesseldorf Worringer Straße to Casello - A1 Ingresso Caianellobus
- Take the bus from Casello - A1 Ingresso Caianello to Iserniabus 6
26h 57m€204–284Train, night train
- Take the train from Venlo to Frankfurt(M) Flughafen Fernbftrain Ice
- Take the train from Frankfurt to München Hbftrain 41 / ...
- Take the nighttrain from Muenchen Hbf to Roma Tiburtinanighttrain Nj
- Take the train from Roma Termini to Iserniatrain Re
25h 44m€173–449Train to Düsseldorf International Airport, fly to Naples Airport, train
- Take the train from Venlo to Duesseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Naples Airport (NAP)plane DUS - NAP
- Take the train from Caserta to Iserniatrain
9h 56m€121–301Fly Eindhoven Airport to Fiumicino International Airport, train
- Fly from Eindhoven Airport (EIN) to Fiumicino International Airport (FCO)plane EIN - FCO
- Take the train from Roma Termini to Iserniatrain
8h 58m€115–330Train to Amsterdam Airport Schiphol, fly to Naples Airport, train
- Take the train from Horst-Sevenum to Schiphol Airport Train Stationtrain
- Fly from Amsterdam Airport Schiphol (AMS) to Naples Airport (NAP)plane AMS - NAP
- Take the train from Caserta to Iserniatrain
10h 17m€135–353Train, train to Brussels Airport, fly to Naples Airport
- Take the train from Eindhoven Centraal to Bredatrain
- Take the train from Breda to Brussels Airport-Zaventemtrain
- Fly from Brussels Airport (BRU) to Naples Airport (NAP)plane BRU - NAP
- Take the train from Caserta to Iserniatrain
11h 1m€117–321Train, bus
- Take the train from Venlo to Duesseldorf Hbftrain
- Take the bus from Düsseldorf central bus station to Frankfurt central train stationbus 068 / ...
- Take the bus from Frankfurt central train station to Pescarabus
- Take the bus from Pescara to Iserniabus 433
29h 27m€171–264Drive 1,629.7 km
- Drive from America to Iserniacar 1,629.7 km
15h 17m€299–432Drive, car train
- Drive from America to Fuldacar
- Take the cartrain from Fulda to Villach Hbfcartrain
- Drive from Villach Hbf to Iserniacar
22h 15m€288–412
Düsseldorf International Airport (DUS) to Fiumicino International Airport (FCO) flights
Comparing Your Travel Options
The cheapest way to get from America to Isernia is to fly and bus which costs €65 - €330 and takes 7h 14m.
The fastest way to get from America to Isernia is to fly and bus which takes 7h 14m and costs €65 - €330.
No, there is no direct bus from America to Isernia. However, there are services departing from Sevenum, Berghemweg and arriving at Isernia via Venlo Station, D-Flughafen Terminal S, Duesseldorf Worringer Straße and Casello - A1 Ingresso Caianello. The journey, including transfers, takes approximately 26h 57m.
No, there is no direct train from America to Isernia. However, there are services departing from Horst-Sevenum and arriving at Isernia via Venlo, Frankfurt, Chiasso, Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 19h 34m.
The distance between America and Isernia is 1436 km. The road distance is 1629.7 km.
The best way to get from America to Isernia without a car is to train which takes 19h 34m and costs €360 - €600.
It takes approximately 9h 46m to get from America to Isernia, including transfers.
America to Isernia bus services, operated by FlixBus, depart from Venlo Station.
America to Isernia train services, operated by Nederlandse Spoorwegen (NS), depart from Venlo station.
The best way to get from America to Isernia is to train which takes 19h 34m and costs €360 - €600. Alternatively, you can bus, which costs €200 - €290 and takes 26h 57m.
What companies run services between America, Netherlands and Isernia, Italy?
You can take a vehicle from America to Isernia via Horst-Sevenum, Venlo, Frankfurt(Main)Hbf, Frankfurt, Chiasso, Milano Centrale, and Roma Termini in around 19h 34m. Alternatively, you can take a vehicle from America to Isernia via Sevenum, Berghemweg, Venlo Station, Düsseldorf Airport, D-Flughafen Terminal S, Düsseldorf Hbf, Duesseldorf Worringer Straße, and Casello - A1 Ingresso Caianello in around 26h 57m.
- Website
- lufthansa.com
Flights from Düsseldorf International Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- €55–310
Flights from Düsseldorf International Airport to Fiumicino International Airport via Frankfurt
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- €85–300
Flights from Düsseldorf International Airport to Naples Airport via Munich
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- €65–340
Flights from Düsseldorf International Airport to Naples Airport via Frankfurt
- Ave. Duration
- 4h 5m
- When
- Wednesday
- Estimated price
- €95–340
Flights from Amsterdam Airport Schiphol to Naples Airport via Frankfurt
- Ave. Duration
- 4h 22m
- When
- Tuesday to Saturday
- Estimated price
- €110–310
Flights from Brussels Airport to Naples Airport via Munich
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- €60–320
- Website
- ita-airways.com
Flights from Düsseldorf International Airport to Fiumicino International Airport via Milan Linate
- Ave. Duration
- 3h 45m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €65–190
Flights from Düsseldorf International Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 5m
- When
- Monday, Wednesday, Thursday, and Friday
- Estimated price
- €85–310
Flights from Düsseldorf International Airport to Naples Airport via Zurich
- Ave. Duration
- 3h 50m
- When
- Wednesday and Thursday
- Estimated price
- €80–320
Flights from Düsseldorf International Airport to Naples Airport via Milan Linate
- Ave. Duration
- 4h 2m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €85–180
Flights from Düsseldorf International Airport to Naples Airport via Munich
- Ave. Duration
- 4h 45m
- When
- Tuesday to Sunday
- Estimated price
- €95–340
Flights from Amsterdam Airport Schiphol to Naples Airport via Milan Linate
- Ave. Duration
- 4h 25m
- When
- Monday to Friday
- Estimated price
- €100–220
Flights from Brussels Airport to Naples Airport via Milan Linate
- Ave. Duration
- 4h 40m
- When
- Monday to Saturday
- Estimated price
- €80–390
- Website
- easyjet.com
Flights from Düsseldorf International Airport to Naples Airport via Milan Malpensa
- Ave. Duration
- 4h 27m
- When
- Tuesday and Sunday
- Estimated price
- €70–250
Flights from Amsterdam Airport Schiphol to Naples Airport
- Ave. Duration
- 2h 27m
- When
- Every day
- Estimated price
- €80–280
- Website
- eurowings.com
Flights from Düsseldorf International Airport to Fiumicino International Airport
- Ave. Duration
- 2h 1m
- When
- Every day
- Estimated price
- €65–190
Flights from Düsseldorf International Airport to Naples Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- €85–180
- Website
- ryanair.com
Flights from Eindhoven Airport to Fiumicino International Airport
- Ave. Duration
- 2h 10m
- When
- Tuesday to Wednesday
- Estimated price
- €60–230
Flights from Weeze Airport to Abruzzo Airport
- Ave. Duration
- 2h
- When
- Tuesday and Thursday
- Estimated price
- €50–320
- Website
- klm.com
Flights from Amsterdam Airport Schiphol to Naples Airport
- Ave. Duration
- 2h 26m
- When
- Every day
- Estimated price
- €80–400
- Website
- lufthansa-city.com
Flights from Düsseldorf International Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 7m
- When
- Monday, Friday, and Saturday
- Estimated price
- €55–300
Flights from Düsseldorf International Airport to Naples Airport via Munich
- Ave. Duration
- 4h 15m
- When
- Monday and Friday
- Estimated price
- €65–340
- Website
- transavia.com
Flights from Amsterdam Airport Schiphol to Naples Airport
- Ave. Duration
- 2h 25m
- When
- Every day
- Estimated price
- €80–400
- Website
- brusselsairlines.com
Flights from Brussels Airport to Naples Airport
- Ave. Duration
- 2h 20m
- When
- Every day
- Estimated price
- €95–390
Flights from Brussels Airport to Naples Airport via Munich
- Ave. Duration
- 5h 30m
- When
- Every day
- Estimated price
- €90–320
- Website
- tui.com
Flights from Düsseldorf International Airport to Naples Airport
- Ave. Duration
- 2h 15m
- When
- Sunday
- Estimated price
- €100–330
- Website
- swiss.com
Flights from Düsseldorf International Airport to Naples Airport via Zurich
- Ave. Duration
- 3h 50m
- When
- Wednesday and Thursday
- Estimated price
- €80–320
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €6–13
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Frankfurt(Main)Hbf
- Ave. Duration
- 2h 53m
- Frequency
- Hourly
- Estimated price
- €29–60
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Frankfurt(M) Flughafen Fernbf
- Ave. Duration
- 2h 37m
- Frequency
- Hourly
- Estimated price
- €28–55
- Website
- Nederlandse Spoorwegen (NS)
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 20m
- Frequency
- 3 times a day
- Estimated price
- €45–90
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €6–13
- Website
- Nederlandse Spoorwegen (NS)
Train from Horst-Sevenum to Schiphol Airport Train Station
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- €18–40
- Website
- Nederlandse Spoorwegen (NS)
Train from Eindhoven Centraal to Breda
- Ave. Duration
- 38 min
- Frequency
- Every 30 minutes
- Estimated price
- €6–13
- Website
- Nederlandse Spoorwegen (NS)
Train from Breda to Brussels Airport-Zaventem
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- €10–21
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €6–13
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- 0180 6 9 27 37 27
- info@eurobahn.de
- Website
- Eurobahn
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 5m
- Frequency
- Hourly
- Estimated price
- €13–18
- Website
- Eurobahn
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 5m
- Frequency
- Hourly
- Estimated price
- €13–18
- Website
- Eurobahn
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 5m
- Frequency
- Hourly
- Estimated price
- €13–18
- Website
- Eurobahn
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Frankfurt to Chiasso
- Ave. Duration
- 6h 49m
- Frequency
- 6 times a week
- Estimated price
- €200–290
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Chiasso to Milano Centrale
- Ave. Duration
- 46 min
- Frequency
- Hourly
- Estimated price
- €17–24
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 5m
- Frequency
- Every 30 minutes
- Estimated price
- €70–120
- Website
- Italo Treno
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Venlo to Frankfurt(M) Flughafen Fernbf
- Ave. Duration
- 2h 21m
- Frequency
- Every 4 hours
- Estimated price
- €45–95
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 31m
- Frequency
- Hourly
- Estimated price
- €70–150
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 221 800 20 80
- info@msm-gruppe.de
- Website
- MSM Partyzug
Train from Frankfurt to München Hbf
- Ave. Duration
- 4h 12m
- Frequency
- Once a week
- Schedules at
- MSM Partyzug
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Muenchen Hbf to Roma Tiburtina
- Ave. Duration
- 14h 6m
- Frequency
- Twice daily
- Estimated price
- €55–140
- Website
- Nightjet
- Sleeper Carriage
- €110–140
- Couchette Carriage
- €85–100
- Seating Carriage
- €55–65
- Phone
- +32 70 79 79 79
- Website
- Belgian Railways
Train from Breda to Brussels Airport-Zaventem
- Ave. Duration
- 1h 7m
- Frequency
- Hourly
- Estimated price
- €16–26
- Website
- Belgian Railways
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- Urlaubs-Express (UEX)
Car train from Fulda to Villach Hbf
- Ave. Duration
- 9h 1m
- Frequency
- Once a week
- Estimated price
- €95–120
- Website
- Urlaubs-Express (UEX)
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Venlo Station to Düsseldorf Airport
- Ave. Duration
- 50 min
- Frequency
- 6 times a week
- Estimated price
- €4–8
- Website
- Flixbus
Bus from Düsseldorf central bus station to Frankfurt central train station
- Ave. Duration
- 3h 50m
- Frequency
- Hourly
- Estimated price
- €19–29
- Website
- Flixbus
Bus from Frankfurt central train station to Pescara
- Ave. Duration
- 18h 40m
- Frequency
- Once daily
- Estimated price
- €110–170
- Website
- Flixbus
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Estimated price
- €12–19
- Website
- Flixbus
- Phone
- +39 0362 185 0590
- info@onebus.it
- Website
- Onebus
Bus from Duesseldorf Worringer Straße to Casello - A1 Ingresso Caianello
- Ave. Duration
- 21h 1m
- Frequency
- Once a week
- Estimated price
- €170–240
- Website
- Onebus
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Casello - A1 Ingresso Caianello to Isernia
- Ave. Duration
- 55 min
- Frequency
- 3 times a day
- Estimated price
- €2–3
- Schedules at
- satiautobus.com
Bus from Pescara Airport to San Salvo Marina
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- €3–5
- Schedules at
- satiautobus.com
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from San Salvo Marina to Isernia
- Ave. Duration
- 1h 12m
- Frequency
- Once a week
- Estimated price
- €4–6
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 20m
- Frequency
- 6 times a week
- Estimated price
- €7–11
- Schedules at
- atm-molise.it
- Phone
- +38 098-888-11-08
- igoruzhanskyi@grandbus.com.ua
- Website
- Grand Bus
Bus from Düsseldorf central bus station to Frankfurt central train station
- Ave. Duration
- 2h 28m
- Frequency
- Once daily
- Estimated price
- €26–29
- Website
- Grand Bus
- Phone
- +421 55 72 896 16
- interbus.sk@gmail.com
- Website
- interbus.sk
Bus from Düsseldorf central bus station to Frankfurt central train station
- Ave. Duration
- 3h 18m
- Frequency
- Once daily
- Schedules at
- interbus.sk
- Book at
- interbus.sk
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Booking & Getting There
America to Isernia bus services, operated by FlixBus, arrive at Düsseldorf Airport station.
America to Isernia train services, operated by Nederlandse Spoorwegen (NS), arrive at Frankfurt(Main)Hbf station.
Yes, the driving distance between America to Isernia is 1630 km. It takes approximately 15h 17m to drive from America to Isernia.
There are 458+ hotels available in Isernia.














































