There are 13 ways to get from America to Isernia by train, plane, train (Trenitalia), bus, night train, car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Düsseldorf International Airport, fly to Fiumicino International Airport, train
best- Take the train from Venlo to Duesseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Fiumicino International Airport (FCO)plane DUS - FCO
- Take the train from Roma Termini to Iserniatrain
9h 50m€129–314Train, train to Brussels Airport, fly to Fiumicino International Airport
cheapest- Take the train from Eindhoven Centraal to Bredatrain
- Take the train from Breda to Brussels Airport-Zaventemtrain
- Fly from Brussels Airport (BRU) to Fiumicino International Airport (FCO)plane BRU - FCO
- Take the train from Roma Termini to Iserniatrain
10h 55m€110–296Train
- Take the train from Venlo to Frankfurt(Main)Hbftrain Ice
- Take the train from Frankfurt to Chiassotrain Ec
- Take the train from Chiasso to Milano Centraletrain S11
- Take the train from Milano Centrale to Roma Terminitrain
- Take the train from Roma Termini to Iserniatrain Re
19h 35m€355–569Bus
- Take the bus from Venlo Station to Düsseldorf Airportbus
- Take the bus from Duesseldorf Worringer Straße to Casello - A1 Ingresso Caianellobus
- Take the bus from Casello - A1 Ingresso Caianello to Iserniabus 6
26h 57m€205–284Train, night train
- Take the train from Venlo to Frankfurt(M) Flughafen Fernbftrain Ice
- Take the train from Frankfurt to München Hbftrain 41 / ...
- Take the nighttrain from Muenchen Hbf to Roma Tiburtinanighttrain Nj
- Take the train from Roma Tiburtina to Iserniatrain Re
25h 32m€172–408Train, train to Cologne Bonn Airport, fly to Fiumicino International Airport
- Take the train from Venlo to Neuss Hbftrain
- Take the train from Neuss Hbf to Koeln/Bonn Flughafentrain
- Fly from Cologne Bonn Airport (CGN) to Fiumicino International Airport (FCO)plane CGN - FCO
- Take the train from Roma Termini to Iserniatrain
10h 10mFly Eindhoven Airport to Fiumicino International Airport, train
- Fly from Eindhoven Airport (EIN) to Fiumicino International Airport (FCO)plane EIN - FCO
- Take the train from Roma Termini to Iserniatrain
8h 58m€125–314Train to Düsseldorf International Airport, fly to Naples Airport, train
- Take the train from Venlo to Duesseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Naples Airport (NAP)plane DUS - NAP
- Take the train from Caserta to Iserniatrain
10h 1m€116–317Train to Amsterdam Airport Schiphol, fly to Florence Peretola Airport, train
- Take the train from Horst-Sevenum to Schiphol Airport Train Stationtrain
- Fly from Amsterdam Airport Schiphol (AMS) to Florence Peretola Airport (FLR)plane AMS - FLR
- Take the train from Firenze S.M.N. to Roma Terminitrain
- Take the train from Roma Termini to Iserniatrain
11h 24m€191–361Train, bus to Brussels South Charleroi Airport, fly to Roma Ciampino Airport
- Take the train from Eindhoven Centraal to Maastrichttrain
- Take the bus from Maastricht Meerssenerweg 231 to Charleroi Airportbus
- Fly from Brussels South Charleroi Airport (CRL) to Roma Ciampino Airport (CIA)plane CRL - CIA
- Take the train from Roma Termini to Iserniatrain
12h 44m€142–485Train, bus
- Take the train from Venlo to Duesseldorf Hbftrain
- Take the bus from Düsseldorf central bus station to Frankfurt central train stationbus 068 / ...
- Take the bus from Frankfurt central train station to Pescarabus
- Take the bus from Pescara to Iserniabus 433 / ...
29h 43m€174–277Drive 1,629.7 km
- Drive from America to Iserniacar 1,629.7 km
15h 17m€338–488Drive, car train
- Drive from America to Fuldacar
- Take the cartrain from Fulda to Villach Hbfcartrain
- Drive from Villach Hbf to Iserniacar
21h 58m€307–433
Düsseldorf International Airport (DUS) to Fiumicino International Airport (FCO) flights
Comparing Your Travel Options
The cheapest way to get from America to Isernia is to train and fly which costs €120 - €320 and takes 9h 50m.
The fastest way to get from America to Isernia is to fly and train which takes 8h 58m and costs €120 - €320.
No, there is no direct bus from America to Isernia. However, there are services departing from Sevenum, Berghemweg and arriving at Isernia via Venlo Station, D-Flughafen Terminal S, Duesseldorf Worringer Straße and Casello - A1 Ingresso Caianello. The journey, including transfers, takes approximately 26h 57m.
No, there is no direct train from America to Isernia. However, there are services departing from Horst-Sevenum and arriving at Isernia via Venlo, Frankfurt, Chiasso, Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 19h 35m.
The distance between America and Isernia is 1436 km. The road distance is 1629.7 km.
The best way to get from America to Isernia without a car is to train which takes 19h 35m and costs €350 - €600.
It takes approximately 9h 50m to get from America to Isernia, including transfers.
America to Isernia bus services, operated by FlixBus, depart from Venlo Station.
America to Isernia train services, operated by Nederlandse Spoorwegen (NS), depart from Venlo station.
The best way to get from America to Isernia is to train which takes 19h 35m and costs €350 - €600. Alternatively, you can bus, which costs €200 - €290 and takes 26h 57m.
What companies run services between America, Netherlands and Isernia, Italy?
You can take a vehicle from America to Isernia via Horst-Sevenum, Venlo, Frankfurt(Main)Hbf, Frankfurt, Chiasso, Milano Centrale, and Roma Termini in around 19h 35m. Alternatively, you can take a vehicle from America to Isernia via Sevenum, Berghemweg, Venlo Station, Düsseldorf Airport, D-Flughafen Terminal S, Düsseldorf Hbf, Duesseldorf Worringer Straße, and Casello - A1 Ingresso Caianello in around 26h 57m.
- Website
- lufthansa.com
Flights from Düsseldorf International Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- €50–300
Flights from Düsseldorf International Airport to Fiumicino International Airport via Frankfurt
- Ave. Duration
- 4h 5m
- When
- Tuesday to Sunday
- Estimated price
- €80–300
Flights from Cologne Bonn Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 12m
- When
- Monday, Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- €95–240
Flights from Düsseldorf International Airport to Naples Airport via Munich
- Ave. Duration
- 4h 25m
- When
- Tuesday and Friday
- Estimated price
- €60–340
Flights from Brussels Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 2m
- When
- Every day
- Estimated price
- €90–500
Flights from Amsterdam Airport Schiphol to Florence Peretola Airport via Frankfurt
- Ave. Duration
- 3h 42m
- When
- Every day
- Estimated price
- €100–750
Flights from Amsterdam Airport Schiphol to Florence Peretola Airport via Munich
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- €100–370
- Website
- ita-airways.com
Flights from Düsseldorf International Airport to Fiumicino International Airport via Milan Linate
- Ave. Duration
- 3h 45m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €55–190
Flights from Düsseldorf International Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 35m
- When
- Every day
- Estimated price
- €80–300
Flights from Cologne Bonn Airport to Fiumicino International Airport
- Ave. Duration
- 2h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €70–200
Flights from Brussels Airport to Fiumicino International Airport
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- €75–190
Flights from Brussels Airport to Fiumicino International Airport via Milan Linate
- Ave. Duration
- 3h 41m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €75–190
- Website
- ryanair.com
Flights from Cologne Bonn Airport to Fiumicino International Airport
- Ave. Duration
- 2h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €60–230
Flights from Eindhoven Airport to Fiumicino International Airport
- Ave. Duration
- 2h 10m
- When
- Tuesday, Friday, Saturday, and Sunday
- Estimated price
- €65–220
Flights from Brussels South Charleroi Airport to Roma Ciampino Airport
- Ave. Duration
- 2h
- When
- Every day
- Estimated price
- €55–360
- Website
- eurowings.com
Flights from Düsseldorf International Airport to Fiumicino International Airport
- Ave. Duration
- 2h 5m
- When
- Every day
- Estimated price
- €55–190
Flights from Cologne Bonn Airport to Fiumicino International Airport
- Ave. Duration
- 2h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €70–200
Flights from Düsseldorf International Airport to Naples Airport
- Ave. Duration
- 2h 15m
- When
- Tuesday
- Estimated price
- €75–180
- Website
- brusselsairlines.com
Flights from Brussels Airport to Fiumicino International Airport
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- €75–190
- Website
- swiss.com
Flights from Düsseldorf International Airport to Naples Airport via Zurich
- Ave. Duration
- 4h 30m
- When
- Tuesday
- Estimated price
- €75–310
Flights from Brussels Airport to Fiumicino International Airport via Zurich
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- €160–290
Flights from Amsterdam Airport Schiphol to Florence Peretola Airport via Zurich
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- €100–330
- Website
- klm.com
Flights from Amsterdam Airport Schiphol to Florence Peretola Airport
- Ave. Duration
- 1h 57m
- When
- Every day
- Estimated price
- €80–440
- Website
- easyjet.com
Flights from Brussels Airport to Fiumicino International Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- €40–150
Flights from Brussels Airport to Fiumicino International Airport via Geneva
- Ave. Duration
- 3h 50m
- When
- Friday and Sunday
- Estimated price
- €40–150
- Website
- lufthansa-city.com
Flights from Düsseldorf International Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 20m
- When
- Wednesday and Saturday
- Estimated price
- €50–290
- Website
- tui.com
Flights from Düsseldorf International Airport to Naples Airport
- Ave. Duration
- 2h 15m
- When
- Sunday
- Estimated price
- €95–310
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Every 30 minutes
- Estimated price
- €6–12
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Frankfurt(Main)Hbf
- Ave. Duration
- 2h 53m
- Frequency
- Hourly
- Estimated price
- €29–55
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Frankfurt(M) Flughafen Fernbf
- Ave. Duration
- 2h 37m
- Frequency
- Hourly
- Estimated price
- €28–50
- Website
- Nederlandse Spoorwegen (NS)
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 20m
- Frequency
- 5 times a day
- Estimated price
- €45–85
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Neuss Hbf
- Ave. Duration
- 51 min
- Frequency
- Every 30 minutes
- Estimated price
- €5–10
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Every 30 minutes
- Estimated price
- €6–12
- Website
- Nederlandse Spoorwegen (NS)
Train from Eindhoven Centraal to Breda
- Ave. Duration
- 38 min
- Frequency
- Hourly
- Estimated price
- €6–12
- Website
- Nederlandse Spoorwegen (NS)
Train from Breda to Brussels Airport-Zaventem
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- €10–19
- Website
- Nederlandse Spoorwegen (NS)
Train from Horst-Sevenum to Schiphol Airport Train Station
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- €18–35
- Website
- Nederlandse Spoorwegen (NS)
Train from Eindhoven Centraal to Maastricht
- Ave. Duration
- 1h 2m
- Frequency
- Hourly
- Estimated price
- €11–20
- Website
- Nederlandse Spoorwegen (NS)
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Every 30 minutes
- Estimated price
- €6–12
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- 0180 6 9 27 37 27
- info@eurobahn.de
- Website
- Eurobahn
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €13–18
- Website
- Eurobahn
Train from Venlo to Neuss Hbf
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- €11–16
- Website
- Eurobahn
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €13–18
- Website
- Eurobahn
Train from Venlo to Duesseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €13–18
- Website
- Eurobahn
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- Twice daily
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 4 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 4h 6m
- Frequency
- 3 times a day
- Estimated price
- €30–45
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–30
- Website
- Trenitalia
Train from Frankfurt to Chiasso
- Ave. Duration
- 6h 49m
- Frequency
- 6 times a week
- Estimated price
- €200–320
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Chiasso to Milano Centrale
- Ave. Duration
- 46 min
- Frequency
- Hourly
- Estimated price
- €17–26
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 5m
- Frequency
- Every 30 minutes
- Estimated price
- €65–110
- Website
- Italo Treno
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 47m
- Frequency
- Twice daily
- Estimated price
- €30–50
- Website
- Italo Treno
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Venlo to Frankfurt(M) Flughafen Fernbf
- Ave. Duration
- 2h 21m
- Frequency
- Every 4 hours
- Estimated price
- €40–80
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 31m
- Frequency
- Hourly
- Estimated price
- €65–130
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 221 800 20 80
- info@msm-gruppe.de
- Website
- MSM Partyzug
Train from Frankfurt to München Hbf
- Ave. Duration
- 4h 12m
- Frequency
- Once a week
- Schedules at
- MSM Partyzug
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Muenchen Hbf to Roma Tiburtina
- Ave. Duration
- 14h 6m
- Frequency
- Twice daily
- Estimated price
- €55–140
- Website
- Nightjet
- Sleeper Carriage
- €110–140
- Couchette Carriage
- €85–100
- Seating Carriage
- €55–65
- Phone
- +49 221 13 999 444
- Website
- National Express
Train from Neuss Hbf to Koeln/Bonn Flughafen
- Ave. Duration
- 48 min
- Frequency
- Every 30 minutes
- Schedules at
- National Express
- Phone
- +32 70 79 79 79
- Website
- Belgian Railways
Train from Breda to Brussels Airport-Zaventem
- Ave. Duration
- 1h 7m
- Frequency
- Hourly
- Estimated price
- €16–26
- Website
- Belgian Railways
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 43m
- Frequency
- Every 20 minutes
- Estimated price
- €35–60
- Website
- Trenitalia Frecce
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- Twice daily
- Estimated price
- €29–55
- Website
- Trenitalia Intercity
- Phone
- 0800-0232 545
- Website
- Arriva NL
Train from Eindhoven Centraal to Maastricht
- Ave. Duration
- 1h 1m
- Frequency
- Once a week
- Estimated price
- €15–23
- Website
- Arriva NL
- Second Class Single
- €15–23
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- Urlaubs-Express (UEX)
Car train from Fulda to Villach Hbf
- Ave. Duration
- 8h 44m
- Frequency
- Once a week
- Estimated price
- €95–120
- Website
- Urlaubs-Express (UEX)
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Venlo Station to Düsseldorf Airport
- Ave. Duration
- 50 min
- Frequency
- 6 times a week
- Estimated price
- €5–8
- Website
- Flixbus
Bus from Düsseldorf central bus station to Frankfurt central train station
- Ave. Duration
- 3h 50m
- Frequency
- Hourly
- Estimated price
- €19–29
- Website
- Flixbus
Bus from Frankfurt central train station to Pescara
- Ave. Duration
- 18h 40m
- Frequency
- Once daily
- Estimated price
- €110–180
- Website
- Flixbus
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Twice daily
- Estimated price
- €13–20
- Website
- Flixbus
- Phone
- +39 0362 185 0590
- info@onebus.it
- Website
- Onebus
Bus from Duesseldorf Worringer Straße to Casello - A1 Ingresso Caianello
- Ave. Duration
- 21h 1m
- Frequency
- Once a week
- Estimated price
- €170–240
- Website
- Onebus
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Casello - A1 Ingresso Caianello to Isernia
- Ave. Duration
- 55 min
- Frequency
- 3 times a day
- Estimated price
- €2–3
- Schedules at
- satiautobus.com
- Phone
- +352 50 55 62 63 10
- info@flibco.com
- Website
- Flibco
Bus from Maastricht Meerssenerweg 231 to Charleroi Airport
- Ave. Duration
- 1h 40m
- Frequency
- Every 3 hours
- Estimated price
- €16–35
- Website
- Flibco
- Phone
- +38 098-888-11-08
- igoruzhanskyi@grandbus.com.ua
- Website
- Grand Bus
Bus from Düsseldorf central bus station to Frankfurt central train station
- Ave. Duration
- 2h 28m
- Frequency
- Once daily
- Estimated price
- €26–29
- Website
- Grand Bus
- Phone
- +421 55 72 896 16
- interbus.sk@gmail.com
- Website
- interbus.sk
Bus from Düsseldorf central bus station to Frankfurt central train station
- Ave. Duration
- 3h 18m
- Frequency
- Once daily
- Schedules at
- interbus.sk
- Book at
- interbus.sk
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 20m
- Frequency
- 6 times a week
- Estimated price
- €7–11
- Schedules at
- atm-molise.it
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Booking & Getting There
America to Isernia bus services, operated by FlixBus, arrive at Düsseldorf Airport station.
America to Isernia train services, operated by Nederlandse Spoorwegen (NS), arrive at Frankfurt(Main)Hbf station.
Yes, the driving distance between America to Isernia is 1630 km. It takes approximately 15h 17m to drive from America to Isernia.
Book your America to Isernia train tickets online with Omio.
There are 453+ hotels available in Isernia.







































































