Rome2Rio

How to get fromAmerica to Iserniaby train, plane, train (Eurostar, Trenitalia), bus, night train, car or car train

Find Transport to Isernia

See all options

There are 12 ways to get from America to Isernia by train, plane, train (Eurostar, Trenitalia), bus, night train, car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Düsseldorf International Airport, fly to Naples Airport, train

    best
    1. Take the train from Venlo to Düsseldorf Hbftrain
    2. Fly from Düsseldorf International Airport (DUS) to Naples Airport (NAP)planeDUS - NAP
    3. Take the train from Napoli Centrale to Iserniatrain
    9h 42m
    €112–315

  2. Train to Eindhoven Airport, fly to Fiumicino International Airport, train

    cheapest
    1. Take the train from Horst-Sevenum to Eindhoventrain
    2. Fly from Eindhoven Airport (EIN) to Fiumicino International Airport (FCO)planeEIN - FCO
    3. Take the train from Roma Termini to Iserniatrain
    9h
    €102–274

  3. Train

    1. Take the train from Horst-Sevenum to Eindhoventrain
    2. Take the train from Eindhoven to Rotterdam Centraaltrain
    3. Take the train from Rotterdam Centraal to Chambery Challes Les Eauxtrain
    4. Take the train from Chambery Challes Les Eaux to Milano CentraletrainFr
    5. Take the train from Milano Centrale to Roma TerminitrainFr / ...
    6. Take the train from Roma Termini to IserniatrainRe
    19h 19m
    €342–728

  4. Bus

    1. Take the bus from Venlo Station to Frankfurt central train stationbus
    2. Take the bus from Frankfurt to Termolibus
    3. Take the bus from Termoli Terminal Bus to Iserniabus
    26h 52m
    €142–206

  5. Train, night train

    1. Take the train from Venlo to Düsseldorf Hbftrain
    2. Take the train from Düsseldorf Hbf to München Hbftrain41 / ...
    3. Take the night train from Muenchen Hbf to Roma TiburtinanighttrainNj
    4. Take the train from Roma Tiburtina to IserniatrainRe
    25h
    €160–675

  6. Train to Amsterdam Airport Schiphol, fly to Naples Airport, train

    1. Take the train from Horst-Sevenum to Schiphol Airporttrain
    2. Fly from Amsterdam Airport Schiphol (AMS) to Naples Airport (NAP)planeAMS - NAP
    3. Take the train from Napoli Centrale to Iserniatrain
    9h 51m
    €117–283

  7. Train to Düsseldorf International Airport, fly to Fiumicino International Airport, train

    1. Take the train from Venlo to Düsseldorf Hbftrain
    2. Fly from Düsseldorf International Airport (DUS) to Fiumicino International Airport (FCO)planeDUS - FCO
    3. Take the train from Roma Termini to Iserniatrain
    10h 3m
    €117–290

  8. Train, train to Cologne Bonn Airport, fly to Fiumicino International Airport

    1. Take the train from Venlo to Neuss Hbftrain
    2. Take the train from Neuss Hbf to Koeln/Bonn Flughafentrain
    3. Fly from Cologne Bonn Airport (CGN) to Fiumicino International Airport (FCO)planeCGN - FCO
    4. Take the train from Roma Termini to Iserniatrain
    10h 28m
    €111–298

  9. Train, bus to Brussels South Charleroi Airport, fly to Roma Ciampino Airport

    1. Take the train from Roermond to Maastrichttrain
    2. Take the bus from Maastricht Meerssenerweg 231 to Charleroi Airportbus
    3. Fly from Brussels South Charleroi Airport (CRL) to Roma Ciampino Airport (CIA)planeCRL - CIA
    4. Take the train from Ciampino to Iserniatrain
    12h 13m
    €111–323

  10. Train, bus

    1. Take the train from Venlo to Düsseldorf Hbftrain
    2. Take the bus from Düsseldorf central bus station to Frankfurt central train stationbus027 / ...
    3. Take the bus from Frankfurt central train station to Pescarabus
    4. Take the bus from Pescara to Iserniabus
    29h 21m
    €110–279

  11. Drive 1,610.3 km

    1. Drive from America to Iserniacar1,610.3 km
    15h 40m
    €283–409

  12. Drive, car train

    1. Drive from America to Düsseldorf Hbfcar
    2. Take the car train from Düsseldorf Hbf to Villach Hbfcartrain
    3. Drive from Villach Hbf to Iserniacar
    16h 10m
    €233–1,209

Düsseldorf International Airport (DUS) to Naples Airport (NAP) flights

Calendar17Weekly Planes
Duration3h 38mAverage Duration
Ticket€62Cheapest Price
See schedules

Questions & Answers

What companies run services between America, Netherlands and Isernia, Italy?

You can take a vehicle from America to Isernia via Horst-Sevenum, Eindhoven, Rotterdam Centraal, Chambery Challes Les Eaux, Milano Centrale, and Roma Termini in around 19h 19m. Alternatively, you can take a vehicle from America to Isernia via Sevenum, Berghemweg, Venlo Station, Frankfurt central train station, Frankfurt, and Termoli Terminal Bus in around 26h 52m.

Airlines
Train operators
Bus operators

Want to know more about travelling around Italy

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Italy Travel Guides

Read the travel guideItaly Travel Guides

Trips from America

Trips to Isernia

Popular routes