There are 13 ways to get from America to Isernia by train, plane, train (Eurostar, Trenitalia), bus, night train, car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Düsseldorf International Airport, fly to Naples Airport, train
best- Take the train from Venlo to Düsseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Naples Airport (NAP)plane DUS - NAP
- Take the train from Napoli Centrale to Iserniatrain
9h 42m€112–315Train, train to Brussels Airport, fly to Fiumicino International Airport
cheapest- Take the train from Horst-Sevenum to Eindhoventrain
- Take the train from Eindhoven to Bredatrain
- Take the train from Breda to Brussels Airport-Zaventemtrain
- Fly from Brussels Airport (BRU) to Fiumicino International Airport (FCO)plane BRU - FCO
- Take the train from Roma Termini to Iserniatrain
11h 17m€105–273Train
- Take the train from Horst-Sevenum to Eindhoventrain
- Take the train from Eindhoven to Rotterdam Centraaltrain
- Take the train from Rotterdam Centraal to Chambery Challes Les Eauxtrain
- Take the train from Chambery Challes Les Eaux to Milano Centraletrain Fr
- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Iserniatrain Re
19h 19m€342–728Bus
- Take the bus from Venlo Station to Frankfurt central train stationbus
- Take the bus from Frankfurt to Termolibus
- Take the bus from Termoli Terminal Bus to Iserniabus
26h 52m€142–206Train, night train
- Take the train from Venlo to Düsseldorf Hbftrain
- Take the train from Düsseldorf Hbf to München Hbftrain 41 / ...
- Take the night train from Muenchen Hbf to Roma Tiburtinanighttrain Nj
- Take the train from Roma Tiburtina to Iserniatrain Re
25h€160–675Train to Amsterdam Airport Schiphol, fly to Naples Airport, train
- Take the train from Horst-Sevenum to Schiphol Airporttrain
- Fly from Amsterdam Airport Schiphol (AMS) to Naples Airport (NAP)plane AMS - NAP
- Take the train from Napoli Centrale to Iserniatrain
9h 56m€117–283Train to Düsseldorf International Airport, fly to Fiumicino International Airport, train
- Take the train from Venlo to Düsseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Fiumicino International Airport (FCO)plane DUS - FCO
- Take the train from Roma Termini to Iserniatrain
10h 3m€117–290Train to Amsterdam Airport Schiphol, fly to Fiumicino International Airport, train
- Take the train from Horst-Sevenum to Schiphol Airporttrain
- Fly from Amsterdam Airport Schiphol (AMS) to Fiumicino International Airport (FCO)plane AMS - FCO
- Take the train from Roma Termini to Iserniatrain
10h 1m€132–298Train to Eindhoven Airport, fly to Fiumicino International Airport, train
- Take the train from Horst-Sevenum to Eindhoventrain
- Fly from Eindhoven Airport (EIN) to Fiumicino International Airport (FCO)plane EIN - FCO
- Take the train from Roma Termini to Iserniatrain
9h€107–284Train, train to Cologne Bonn Airport, fly to Fiumicino International Airport
- Take the train from Venlo to Neuss Hbftrain
- Take the train from Neuss Hbf to Koeln/Bonn Flughafentrain
- Fly from Cologne Bonn Airport (CGN) to Fiumicino International Airport (FCO)plane CGN - FCO
- Take the train from Roma Termini to Iserniatrain
10h 28m€111–318Train, bus
- Take the train from Venlo to Düsseldorf Hbftrain
- Take the bus from Düsseldorf central bus station to Frankfurt central train stationbus 027 / ...
- Take the bus from Frankfurt central train station to Pescarabus
- Take the bus from Pescara to Iserniabus
29h 21m€110–279Drive 1,629.4 km
- Drive from America to Iserniacar 1,629.4 km
15h 10m€287–414Drive, car train
- Drive from America to Düsseldorf Hbfcar
- Take the car train from Düsseldorf Hbf to Villach Hbfcartrain
- Drive from Villach Hbf to Iserniacar
16h 10m€233–1,209
Düsseldorf International Airport (DUS) to Naples Airport (NAP) flights
Questions & Answers
The cheapest way to get from America to Isernia is to train and fly which costs €110 - €290 and takes 10h 3m.
The fastest way to get from America to Isernia is to train and fly which takes 9h and costs €100 - €290.
The distance between America and Isernia is 1507 km. The road distance is 1629.4 km.
The best way to get from America to Isernia without a car is to train which takes 19h 19m and costs €340 - €750.
It takes approximately 9h 42m to get from America to Isernia, including transfers.
The best way to get from America to Isernia is to train which takes 19h 19m and costs €340 - €750. Alternatively, you can bus, which costs €140 - €210 and takes 26h 52m.
Yes, the driving distance between America to Isernia is 1629 km. It takes approximately 15h 10m to drive from America to Isernia.
There are 424+ hotels available in Isernia.
What companies run services between America, Netherlands and Isernia, Italy?
You can take a vehicle from America to Isernia via Horst-Sevenum, Eindhoven, Rotterdam Centraal, Chambery Challes Les Eaux, Milano Centrale, and Roma Termini in around 19h 19m. Alternatively, you can take a vehicle from America to Isernia via Sevenum, Berghemweg, Venlo Station, Frankfurt central train station, Frankfurt, and Termoli Terminal Bus in around 26h 52m.
- Website
- ita-airways.com
Flights from Düsseldorf International Airport to Naples Airport via Frankfurt
- Ave. Duration
- 3h 45m
- When
- Thursday, Saturday, and Sunday
- Estimated price
- €85–330
Flights from Düsseldorf International Airport to Naples Airport via Milan Linate
- Ave. Duration
- 4h 35m
- When
- Monday to Friday
- Estimated price
- €65–170
Flights from Düsseldorf International Airport to Fiumicino International Airport via Milan Linate
- Ave. Duration
- 4h 40m
- When
- Monday to Saturday
- Estimated price
- €75–190
Flights from Amsterdam Airport Schiphol to Fiumicino International Airport
- Ave. Duration
- 2h 15m
- When
- Every day
- Estimated price
- €70–250
Flights from Amsterdam Airport Schiphol to Fiumicino International Airport via Milan Linate
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- €70–250
Flights from Cologne Bonn Airport to Fiumicino International Airport
- Ave. Duration
- 1h 55m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €65–190
Flights from Brussels Airport to Fiumicino International Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- €65–260
Flights from Brussels Airport to Fiumicino International Airport via Milan Linate
- Ave. Duration
- 4h 45m
- When
- Tuesday to Saturday
- Estimated price
- €65–260
- Website
- lufthansa.com
Flights from Düsseldorf International Airport to Naples Airport via Frankfurt
- Ave. Duration
- 3h 45m
- When
- Thursday, Saturday, and Sunday
- Estimated price
- €85–330
Flights from Düsseldorf International Airport to Naples Airport via Munich
- Ave. Duration
- 4h 5m
- When
- Monday to Thursday
- Estimated price
- €60–320
Flights from Amsterdam Airport Schiphol to Naples Airport via Munich
- Ave. Duration
- 4h 15m
- When
- Tuesday, Wednesday, Thursday, and Saturday
- Estimated price
- €75–400
Flights from Düsseldorf International Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- €75–310
Flights from Cologne Bonn Airport to Fiumicino International Airport via Munich
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- €85–280
- Website
- klm.com
Flights from Amsterdam Airport Schiphol to Naples Airport
- Ave. Duration
- 2h 25m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €75–390
Flights from Amsterdam Airport Schiphol to Fiumicino International Airport
- Ave. Duration
- 2h 11m
- When
- Every day
- Estimated price
- €65–350
Flights from Amsterdam Airport Schiphol to Fiumicino International Airport via Genoa
- Ave. Duration
- 4h 35m
- When
- Every day
- Estimated price
- €65–350
- Website
- ryanair.com
Flights from Eindhoven Airport to Fiumicino International Airport
- Ave. Duration
- 2h 10m
- When
- Monday, Wednesday, Saturday, and Sunday
- Estimated price
- €60–230
Flights from Cologne Bonn Airport to Fiumicino International Airport
- Ave. Duration
- 2h
- When
- Monday, Thursday, and Saturday
- Estimated price
- €55–200
Flights from Brussels Airport to Fiumicino International Airport
- Ave. Duration
- 2h 10m
- When
- Monday, Tuesday, Friday, and Sunday
- Estimated price
- €40–150
- Website
- easyjet.com
Flights from Amsterdam Airport Schiphol to Naples Airport
- Ave. Duration
- 2h 25m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €60–220
Flights from Brussels Airport to Fiumicino International Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- €35–170
- Website
- brusselsairlines.com
Flights from Brussels Airport to Fiumicino International Airport
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- €65–260
- Website
- eurowings.com
Flights from Düsseldorf International Airport to Naples Airport
- Ave. Duration
- 2h 10m
- When
- Tuesday and Thursday
- Estimated price
- €80–160
Flights from Düsseldorf International Airport to Fiumicino International Airport
- Ave. Duration
- 2h 5m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €75–200
Flights from Cologne Bonn Airport to Fiumicino International Airport
- Ave. Duration
- 1h 55m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €65–190
- Website
- transavia.com
Flights from Amsterdam Airport Schiphol to Naples Airport
- Ave. Duration
- 2h 25m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €75–390
- Website
- swiss.com
Flights from Brussels Airport to Fiumicino International Airport via Zurich
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- €160–210
- Phone
- 0180 6 9 27 37 27
- info@eurobahn.de
- Website
- eurobahn.de
Train from Venlo to Düsseldorf Hbf
- Ave. Duration
- 1h 5m
- Frequency
- Hourly
- Estimated price
- €13–18
- Website
- https://www.eurobahn.de/en/
Train from Venlo to Neuss Hbf
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- €11–16
- Website
- https://www.eurobahn.de/en/
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Venlo to Düsseldorf Hbf
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €11–35
- Website
- https://www.ns.nl/en
- 2nd Class
- €11–16
- 1st Class
- €18–35
Train from Horst-Sevenum to Eindhoven
- Ave. Duration
- 28 min
- Frequency
- Hourly
- Estimated price
- €10
- Website
- https://www.ns.nl/en
Train from Eindhoven to Rotterdam Centraal
- Ave. Duration
- 1h 1m
- Frequency
- Every 30 minutes
- Estimated price
- €17–55
- Website
- https://www.ns.nl/en
- 2nd Class
- €17–26
- 1st Class
- €30–55
Train from Düsseldorf Hbf to München Hbf
- Ave. Duration
- 4h 53m
- Frequency
- 3 times a day
- Estimated price
- €90–320
- Website
- https://www.ns.nl/en
- 2nd Class
- €90–140
- 1st Class
- €190–320
Train from Horst-Sevenum to Schiphol Airport
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- €29
- Website
- https://www.ns.nl/en
Train from Venlo to Neuss Hbf
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Estimated price
- €9–26
- Website
- https://www.ns.nl/en
- 2nd Class
- €9–14
- 1st Class
- €15–26
Train from Eindhoven to Breda
- Ave. Duration
- 38 min
- Frequency
- Every 30 minutes
- Estimated price
- €14
- Website
- https://www.ns.nl/en
- Website
- traincharter.eu
Train from Venlo to Düsseldorf Hbf
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Schedules at
- traincharter.eu
Train from Venlo to Neuss Hbf
- Ave. Duration
- 51 min
- Frequency
- Once daily
- Schedules at
- traincharter.eu
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
Train from Chambery Challes Les Eaux to Milano Centrale
- Ave. Duration
- 3h 21m
- Frequency
- Twice daily
- Estimated price
- €55–140
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- 6 times a week
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
- Phone
- +44 343 218 6186
- Website
- eurostar.com
Train from Rotterdam Centraal to Chambery Challes Les Eaux
- Ave. Duration
- 5h 42m
- Frequency
- 3 times a week
- Estimated price
- €190–370
- Website
- https://www.eurostar.com/rw-en
- Standard
- €190–270
- Comfort
- €220–310
- Premium
- €280–370
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €50–120
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 39m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Düsseldorf Hbf to München Hbf
- Ave. Duration
- 4h 45m
- Frequency
- Hourly
- Estimated price
- €45–140
- Website
- https://int.bahn.de/en
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Muenchen Hbf to Roma Tiburtina
- Ave. Duration
- 13h 58m
- Frequency
- Once daily
- Estimated price
- €75–280
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €260–280
- Couchette Carriage
- €160–190
- Seating Carriage
- €75–100
- Phone
- 0221 13 999 444
- Website
- nationalexpress.de
Train from Neuss Hbf to Koeln/Bonn Flughafen
- Ave. Duration
- 47 min
- Frequency
- Hourly
- Estimated price
- €10–16
- Schedules at
- nationalexpress.de
- Phone
- +32 70 79 79 79
- Website
- belgiantrain.be
Train from Breda to Brussels Airport-Zaventem
- Ave. Duration
- 1h 7m
- Frequency
- Hourly
- Estimated price
- €18–20
- Website
- https://www.belgiantrain.be/en
- 2nd Class
- €18–20
- 1st Class
- €25–29
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from Düsseldorf Hbf to Villach Hbf
- Ave. Duration
- 5h 53m
- Frequency
- Once a week
- Estimated price
- €100–1,000
- Website
- https://urlaubs-express.de/?lang=en
- Car Single Bed
- €270–550
- Car Compartment
- €550–1,000
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Venlo Station to Frankfurt central train station
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- €19–55
- Website
- https://www.flixbus.co.uk
Bus from Düsseldorf central bus station to Frankfurt central train station
- Ave. Duration
- 3h 40m
- Frequency
- Hourly
- Estimated price
- €13–26
- Website
- https://www.flixbus.co.uk
Bus from Frankfurt central train station to Pescara
- Ave. Duration
- 18h 40m
- Frequency
- Twice daily
- Estimated price
- €60–160
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Twice daily
- Estimated price
- €18–35
- Website
- https://www.flixbus.co.uk
- Phone
- +39 098 3520 315
- info@fsbusitaliafast.it
- Website
- simetbus.it
Bus from Frankfurt to Termoli
- Ave. Duration
- 15h 57m
- Frequency
- Once a week
- Estimated price
- €100–120
- Schedules at
- simetbus.it
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Termoli Terminal Bus to Isernia
- Ave. Duration
- 1h 35m
- Frequency
- Once a week
- Estimated price
- €5–8
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
Want to know more about Flixbus?
Read the travel guide





























































