There are 9 ways to get from Chicago to Missouri by plane, train (Amtrak), bus (Greyhound), car, or subway
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport
best- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane ORD - STL
3h 45m$276–608Fly Chicago O'Hare International Airport to Springfield-Branson National Airport
cheapest- Fly from Chicago O'Hare International Airport (ORD) to Springfield-Branson National Airport (SGF)plane ORD - SGF
3h 42m$74–355Train (Amtrak)
- Take the train from Chicago Union Station to Kansas Citytrain Southwest Chief / ...
7h 36m$130–280Bus
- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123S / ...
- Take the bus from Des Moines to Kansas Citybus Jefferson 803 / ...
11h$100–168Drive 506.6 mi
- Drive from Chicago to Kansas Citycar 506.6 mi
8h 37m$93–134Subway to Chicago Midway International Airport, fly to Lambert–St. Louis International Airport
- Take the subway from Adams/Wabash to Midwaysubway
- Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane MDW - STL
3h 27m$116–758Fly Chicago O'Hare International Airport to Columbia Regional Airport
- Fly from Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU)plane ORD - COU
3h 34m$98–370Subway to Chicago Midway International Airport, fly to Kansas City
- Take the subway from Adams/Wabash to Midwaysubway
- Fly from Chicago Midway International Airport (MDW) to Kansas City (MCI)plane MDW - MCI
4h 39m$142–855Fly Chicago O'Hare International Airport to Kansas City
- Fly from Chicago O'Hare International Airport (ORD) to Kansas City (MCI)plane ORD - MCI
5h 6m$232–505
Chicago to Missouri by train and tram (Amtrak)
Questions & Answers
The cheapest way to get from Chicago to Missouri is to drive which costs $90 - $140 and takes 8h 37m.
The fastest way to get from Chicago to Missouri is to subway and fly which takes 3h 27m and costs $110 - $800.
No, there is no direct bus from Chicago station to Missouri. However, there are services departing from Chicago Bus Station and arriving at Kansas City via Des Moines. The journey, including transfers, takes approximately 11h.
No, there is no direct train from Chicago station to Missouri. However, there are services departing from Chicago Union Station and arriving at Metro Center via Union Station. The journey, including transfers, takes approximately 7h 36m.
The distance between Chicago and Missouri is 292 miles. The road distance is 509.6 miles.
The best way to get from Chicago to Missouri without a car is to train which takes 7h 36m and costs $130 - $280.
It takes approximately 3h 45m to get from Chicago to Missouri, including transfers.
Chicago to Missouri bus services, operated by Greyhound USA, depart from Chicago Bus Station.
Chicago to Missouri train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago to Missouri is to fly which takes 3h 45m and costs $270 - $650. Alternatively, you can train, which costs $130 - $280 and takes 7h 36m, you could also bus, which costs $95 - $170 and takes 11h.
What companies run services between Chicago, IL, USA and Missouri, USA?
American Airlines, GoJet Airlines, and United Airlines fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Amtrak operates a train from Chicago Union Station to Kansas City twice daily. Tickets cost $130–280 and the journey takes 7h 23m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- $110–750
Flights from Chicago Midway International Airport to Kansas City
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $140–850
Flights from Chicago Midway International Airport to Kansas City via Lambert–St. Louis International Airport
- Ave. Duration
- 3h 32m
- When
- Monday to Wednesday
- Estimated price
- $160–900
Flights from Chicago Midway International Airport to Kansas City via Milwaukee
- Ave. Duration
- 3h 15m
- When
- Monday, Thursday, and Friday
- Estimated price
- $160–950
Flights from Chicago Midway International Airport to Kansas City via Indianapolis
- Ave. Duration
- 3h 35m
- When
- Tuesday and Wednesday
- Estimated price
- $180–1,000
- Website
- united.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $75–550
Flights from Chicago O'Hare International Airport to Columbia Regional Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $45–300
Flights from Chicago O'Hare International Airport to Springfield-Branson National Airport
- Ave. Duration
- 1h 52m
- When
- Every day
- Estimated price
- $55–330
Flights from Chicago O'Hare International Airport to Kansas City
- Ave. Duration
- 1h 48m
- When
- Every day
- Estimated price
- $100–600
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $75–550
Flights from Chicago O'Hare International Airport to Columbia Regional Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $45–300
Flights from Chicago O'Hare International Airport to Springfield-Branson National Airport
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $55–330
Flights from Chicago O'Hare International Airport to Kansas City
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $100–600
- Website
- delta.com
Flights from Chicago O'Hare International Airport to Kansas City via Minneapolis
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $140–750
- Website
- gojetairlines.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $75–550
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Kansas City
- Ave. Duration
- 7h 23m
- Frequency
- Twice daily
- Estimated price
- $130–280
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888-968-7282
- Website
- transitchicago.com
Subway from Adams/Wabash to Midway
- Ave. Duration
- 23 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- https://www.transitchicago.com
- Schedules at
- https://www.transitchicago.com/schedules/
- Adult
- $2–5
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 30m
- Frequency
- 3 times a day
- Estimated price
- $45–95
- Website
- https://www.greyhound.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $50–75
- Book at
- https://www.jeffersonlines.com
- Adult
- $50–75
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More Questions & Answers
Chicago to Missouri bus services, operated by Greyhound USA, arrive at Des Moines station.
Chicago to Missouri train services, operated by Amtrak, arrive at Kansas City station.
Yes, the driving distance between Chicago to Missouri is 510 miles. It takes approximately 8h 37m to drive from Chicago to Missouri.
There are 553+ hotels available in Missouri.